Abstract:
INTRODUCTION:Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea in infancy. A variant with onset in adulthood has recently been described. The immune mechanisms underlying AIE are unclear and the experience in the management of adult AIE is very limited. CASE REPORT:A 19-year-old male patient with massive refractory diarrhea and significant weight loss was diagnosed with AIE. He did not improve with corticosteroid and azathioprine treatment and was then treated successfully with infliximab. The response to treatment was rapid and complete. Because of a severe life-threatening hypersensitivity reaction during the 4th infliximab dose, infliximab had to be discontinued and therapy with tacrolimus was initiated. A complete clinical remission has since been maintained. CONCLUSION:Both infliximab and tacrolimus may provide a therapeutic alternative in patients with adult refractory AIE.
journal_name
Digestionjournal_title
Digestionauthors
von Hahn T,Stopik D,Koch M,Wiedenmann B,Dignass Adoi
10.1159/000084648subject
Has Abstractpub_date
2005-01-01 00:00:00pages
141-4issue
3eissn
0012-2823issn
1421-9867pii
84648journal_volume
71pub_type
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