Immature parietal cells in healing gastric wounds respond to stimulation. An experimental study in rats.

abstract：:High-fidelity simulation uses simulators that combine all of the physiological and pharmacological responses of a human in a manikin. These simulators change and respond to the users and trainees. Using simulators for teaching sedation in the field of gastroenterology unifies all the advantages of manikins. To underst...

journal_title：Digestion

authors： Hofmann N,Datz C,Schöchl H

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Symptoms caused by chronic pancreatitis (CP) are common but often elusive hampering therapeutic decisions. Though correlations of morphologic findings in imaging and clinical appearance remain vague. We aimed in investigating whether a distinct combination of clinical parameters can better define the extent ...

journal_title：Digestion

authors： Perkhofer L,Besold T,Schmidberger J,Seufferlein T,Hann A,Müller M,Kleger A

更新日期：2020-02-11 00:00:00

abstract：:It is now generally admitted that phytohemagglutinin (PHA) constitutes the main factor responsible for the dietary toxicity of raw kidney beans. In the growing rat, an impairment of growth is the unique expression of a malnutrition syndrome. The aim of this work was to precise to what extent the intestinal injuries ma...

journal_title：Digestion

authors： Lafont J,Rouanet JM,Gabrion J,Assouad JL,Zambonino Infante JL,Besançon P

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND/AIMS:In this study, a clinical and serological follow-up of 8-10 years was performed in relatives of celiac disease (CD) patients from southern Brazil. The occurrence of new CD cases in the families and the use of two different IgA-tTG enzyme-linked immunosorbent assay (ELISA) kits were also evaluated. METH...

journal_title：Digestion

authors： Nass FR,Kotze LM,Nisihara RM,de Messias-Reason IJ,Ramos da Rosa Utiyama S

更新日期：2011-01-01 00:00:00

abstract：:We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...

journal_title：Digestion

authors： Ahlman H

更新日期：1996-01-01 00:00:00

abstract：:Natural motilin was investigated for its effect on gastrointestinal motor activity in anesthetized dogs. In doses starting from 10 ng/kg as single injection and 100 ng/kg-h as intravenous infusion, motilin induced phasic pressure changes in the lower esophageal sphincter (LES) and in the lumen of the fundus, antrum, a...

journal_title：Digestion

authors： Jennewein HM,Hummelt H,Siewert R,Waldeck F

更新日期：1975-01-01 00:00:00

abstract：:Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/o...

journal_title：Digestion

authors： Nakamura T,Nagahori M,Kanai T,Watanabe M

更新日期：2008-01-01 00:00:00

abstract：:The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...

journal_title：Digestion

authors： Takeuchi K,Johnson LR

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Adenosine deaminase (ADA)-deficient disease, a severe combined immunodeficiency, is most commonly associated with gastrointestinal disorders such as ulcer. The present study investigated the role of ADA in the pathogenesis of gastric ulcer. METHODS:ADA activity was measured in a variety of organs and t...

journal_title：Digestion

authors： Yaguchi T,Saito M,Yasuda Y,Nishizaki T

更新日期：2010-01-01 00:00:00

abstract：:Putrescine, the product of the ornithine decarboxylase (ODC)-catalyzed reaction, stimulates macromolecular synthesis in a duodenal crypt cell line, IEC-6 cells, grown in culture. In addition, supplementation of medium with putrescine alone reverses the inhibition of proliferation produced by inhibition of ODC with dif...

journal_title：Digestion

authors： Seidel ER,Ginty DD

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:The present study aimed to evaluate the micronucleus (MN), nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in the mitogen-stimulated lymphocytes of patients with ulcerative colitis (UC). In addition, we assessed MN frequency in exfoliated colonic epithelial cells obtained from both the diseased and heal...

journal_title：Digestion

authors： Karaman A,Hamurcu Z,Donmez H,Bitken N,Karaman H,Baskol M,Gursoy S,Guven K,Ozbakir O,Yucesoy M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hepatocyte growth factor (HGF) stimulates proliferation, migration and morphogenesis of epithelial cells by specific binding to its receptor c-met. Overexpression of HGF or c-met has been reported for human gastric or pancreatic cancer. In colorectal cancer overexpression of c-met but not HGF has been shown....

journal_title：Digestion

authors： Otte JM,Schmitz F,Kiehne K,Stechele HU,Banasiewicz T,Krokowicz P,Nakamura T,Fölsch UR,Herzig K

更新日期：2000-01-01 00:00:00

abstract：:Gastrinomas may occur in the pancreas, duodenum or peripancreatic lymph nodes. The gastrin overproduction leads to the Zollinger-Ellison syndrome with multiple gastric and duodenal ulcers and diarrhea. About two thirds of gastrinomas are malignant. Diagnosis is made by clinical history, gastroscopy, and measurement of...

journal_title：Digestion

authors： Granberg D,Jacobsson H,Oberg K,Gustavsson J,Lehtihet M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) is a functional bowel disorder which is characterized by abdominal pain and disturbed bowel habits. The pathophysiological mechanism is complex and still remains incompletely clear. Alterations at both the central and the peripheral level are thought to contribute to the sympto...

journal_title：Digestion

authors： Zhang H,Yan Y,Shi R,Lin Z,Wang M,Lin L

更新日期：2008-01-01 00:00:00

abstract：:The adaptive increase in bile flow was studied up to 24 h after selective biliary obstruction (SBO) in the rat. Between 6 and 12 h after SBO bile flow increased significantly, such that 12 and 24 h after SBO bile flow did not differ significantly from control. The prior administration of cycloheximide (300 micrograms/...

journal_title：Digestion

authors： Mackinnon M,Kohler M

更新日期：1980-01-01 00:00:00

abstract：:Autonomic hyperactivity with increased cardiac output and other manifestations occurs in patients with both cirrhosis and noncirrhotic portal hypertension. The role of the disordered hepatic autonomic innervation in the mediation of these abnormalities is unknown. We have studied the hepatic nerve network and associat...

journal_title：Digestion

authors： Jaskiewicz K,Voigt MD,Robson SC

更新日期：1994-01-01 00:00:00

abstract：:The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...

journal_title：Digestion

authors： Köhler H,Becker HD

更新日期：1987-01-01 00:00:00

abstract：:The core symposiums of the Japanese Gastroenterological Association (JGA) annual scientific meetings focus on similar topics from year to year. The main topics of these symposiums for the last 3 years were centered on progress in new diagnostics and therapeutic strategies for gastrointestinal malignancy, with a specia...

journal_title：Digestion

authors： Sugiyama T

更新日期：2015-01-01 00:00:00

abstract：:To assess the feasibility of a prospective incidence study of inflammatory bowel disease (IBD), the registration methods and incidence figures during 1990 were evaluated. The study was a collaboration between 14 hospitals in an area of close to one million inhabitants. Common diagnostic criteria for ulcerative colitis...

journal_title：Digestion

authors： Moum B,Vatn MH,Ekbom A,Fausa O,Aadland E,Lygren I,Sauar J,Schulz T

更新日期：1995-01-01 00:00:00

abstract：:Diamine oxidase (DAO) is an enzyme located almost exclusively in the villus tip enterocytes of mammals. Its plasma activity, normally very low, is enhanced by intravenous heparin that releases the enzyme from the enterocytes into the blood. Postheparin plasma DAO (PHD) values have been shown to be significantly reduce...

journal_title：Digestion

authors： D'Agostino L,Daniele B,Pignata S,Greco L,Mazzacca G

更新日期：1988-01-01 00:00:00

abstract：:Somatostatin is widely distributed throughout the human gastrointestinal system. There it is found in neurons and fibers of both the submucosal and the myenteric plexus and the pancreas as well as in the D cells of the stomach, gut and pancreatic islets. Whereas in the intestinal nervous system, in the duodenum and th...

journal_title：Digestion

authors： Gyr KE,Meier R

更新日期：1993-01-01 00:00:00

abstract：:This prospective study was designed to validate a novel biopsy urease test as well as a simplified 13C-urea breath test for the detection of Helicobacter pylori. In addition, the hypothesis was tested that both the reaction velocity of the urease test and the 13CO2 excess of the urea breath test may allow a prediction...

journal_title：Digestion

authors： Labenz J,Bärsch G,Peitz U,Aygen S,Hennemann O,Tillenburg B,Becker T,Stolte M

更新日期：1996-11-01 00:00:00

abstract：:Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled. In this study performed on 16 young male subjects, gastric acid secretion and emptying rate were determined after intragastric administration of 8% pep...

journal_title：Digestion

authors： Konturek SJ,Kwiecien N,Obtulowicz W,Kopp B,Oleksy J,Rovati L

更新日期：1990-01-01 00:00:00

abstract：:The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...

journal_title：Digestion

authors： Beglinger C,Köhler E,Stalder GA,Jansen J,Gyr K

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Gastric cancers are characterized by a heterogeneously hypoxic environment. Hypoxia might stimulate the malignant potential of cancer cells. The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydras...

journal_title：Digestion

authors： Kato Y,Yashiro M,Noda S,Kashiwagi S,Matsuoka J,Fuyuhiro Y,Doi Y,Hirakawa K

更新日期：2010-01-01 00:00:00

abstract：:We demonstrate that, in patients taking non-steroidal anti-inflammatory drugs (NSAIDs), there is inhibition of the proliferation of mucosal cells that normally leads to healing of duodenal ulcers. A microdissection technique was used to quantitate mitosis in duodenal crypts at the ulcer edge, giving a regeneration ind...

journal_title：Digestion

authors： Levi S,Goodlad RA,Lee CY,Stamp G,Walport MJ,Wright NA,Hodgson HJ

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Overt hepatic encephalopathy (HE) following insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a problem in some patients. In contrast to overt HE, minimal HE (MHE) following TIPS is studied to a limited degree only. We therefore evaluated the incidence of MHE in patients following TIPS i...

journal_title：Digestion

authors： Biecker E,Hausdörfer I,Grünhage F,Strunk H,Sauerbruch T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Few prospective population-based studies have been carried out on the incidence of inflammatory bowel disease (IBD). In a population-based study of pediatric IBD in southeastern Norway, patients <16 years at the time of diagnosis were followed up prospectively. The study reports on changes in diagnosis and c...

journal_title：Digestion

authors： Størdal K,Jahnsen J,Bentsen BS,Moum B

更新日期：2004-01-01 00:00:00

abstract：:The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 ...

journal_title：Digestion

authors： Wereszczyńska-Siemiatkowska U,Pohl U,Otto J,Lankisch PG

更新日期：1987-01-01 00:00:00

abstract：:Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn's disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 pati...

journal_title：Digestion

authors： Imes S,Pinchbeck B,Dinwoodie A,Walker K,Thomson AB

更新日期：1987-01-01 00:00:00