解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20831-8
更新日期:2021-01-29 00:00:00
abstract::Here we benchmark device-to-device variation in field-effect transistors (FETs) based on monolayer MoS2 and WS2 films grown using metal-organic chemical vapor deposition process. Our study involves 230 MoS2 FETs and 160 WS2 FETs with channel lengths ranging from 5 μm down to 100 nm. We use statistical measures to eval...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20732-w
更新日期:2021-01-29 00:00:00
abstract::Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here, we present Methyl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20984-0
更新日期:2021-01-29 00:00:00
abstract::Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20822-9
更新日期:2021-01-28 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this transformation occurs are still unclear. Here, hyperpolyploidization of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20572-8
更新日期:2021-01-28 00:00:00
abstract::Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here we describe time-course single-cell-transcriptomic analysis of develop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20892-3
更新日期:2021-01-28 00:00:00
abstract::Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with nanocarrier surfaces. Albumin is initially one of the dominant proteins ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20886-7
更新日期:2021-01-28 00:00:00
abstract::Perovskite light emitting diodes suffer from poor operational stability, exhibiting a rapid decay of external quantum efficiency within minutes to hours after turn-on. To address this issue, we explore surface treatment of perovskite films with phenylalkylammonium iodide molecules of varying alkyl chain lengths. Combi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20970-6
更新日期:2021-01-28 00:00:00
abstract::Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments. Here, we use single-molecule imaging in live cells to directly study the beh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20672-5
更新日期:2021-01-27 00:00:00
abstract::Confined samples of liquid crystals are characterized by a variety of topological defects and can be exposed to external constraints such as extreme confinements with nontrivial topology. Here we explore the intrinsic structure of smectic colloidal layers dictated by the interplay between entropy and an imposed extern...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20842-5
更新日期:2021-01-27 00:00:00
abstract::Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer transcription factors have prominent roles in this process because of their ability to contact their cognate binding motifs in closed chromatin. Reprogramming is pervasive in plants, whose development is plastic and tuned by the envi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20883-w
更新日期:2021-01-27 00:00:00
abstract::Self-repairable materials strive to emulate curable and resilient biological tissue; however, their performance is currently insufficient for commercialization purposes because mending and toughening are mutually exclusive. Herein, we report a carbonate-type thermoplastic polyurethane elastomer that self-heals at 35 °...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20931-z
更新日期:2021-01-27 00:00:00
abstract::Liquid crystalline network (LCN) actuator normally deforms upon thermally or optically induced order-disorder phase transition, switching once between two shapes (shape 1 in LC phase and shape 2 in isotropic state) for each stimulation on/off cycle. Herein, we report an LCN actuator that deforms from shape 1 to shape ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20938-6
更新日期:2021-01-27 00:00:00
abstract::5-Methylfurfural (MF) is a very useful chemical. Selective hydrogenation of biomass platform molecule 5-(hydroxymethyl)furfural (HMF) to MF using H2 as the reducing agent is very attractive, but challenging because hydrogenation of C=O bond in HMF is more favourable than C-OH both kinetically and thermodynamically, an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20878-7
更新日期:2021-01-26 00:00:00
abstract::Plasma dynamics critically depends on density and temperature, thus well-controlled experimental realizations are essential benchmarks for theoretical models. The formation of an ultracold plasma can be triggered by ionizing a tunable number of atoms in a micrometer-sized volume of a 87Rb Bose-Einstein condensate (BEC...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20815-8
更新日期:2021-01-26 00:00:00
abstract::Melting of the Greenland Ice Sheet is a leading cause of land-ice mass loss and cryosphere-attributed sea level rise. Blooms of pigmented glacier ice algae lower ice albedo and accelerate surface melting in the ice sheet's southwest sector. Although glacier ice algae cause up to 13% of the surface melting in this regi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20627-w
更新日期:2021-01-25 00:00:00
abstract::Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here we report that mic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20774-0
更新日期:2021-01-25 00:00:00
abstract::Aviation emissions of nitrogen oxides (NOx) alter the composition of the atmosphere, perturbing the greenhouse gases ozone and methane, resulting in positive and negative radiative forcing effects, respectively. In 1981, the International Civil Aviation Organization adopted a first certification standard for the regul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20771-3
更新日期:2021-01-25 00:00:00
abstract::Despite the pursuit of quantum advantages in various applications, the power of quantum computers in executing neural network has mostly remained unknown, primarily due to a missing tool that effectively designs a neural network suitable for quantum circuit. Here, we present a neural network and quantum circuit co-des...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20729-5
更新日期:2021-01-25 00:00:00
abstract::Marine low clouds play an important role in the climate system, and their properties are sensitive to cloud condensation nuclei concentrations. While new particle formation represents a major source of cloud condensation nuclei globally, the prevailing view is that new particle formation rarely occurs in remote marine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20773-1
更新日期:2021-01-22 00:00:00
abstract::Homozygosity mapping is a powerful method for identifying mutations in patients with recessive conditions, especially in consanguineous families or isolated populations. Historically, it has been used in conjunction with genotypes from highly polymorphic markers, such as DNA microsatellites or common SNPs. Traditional...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20584-4
更新日期:2021-01-22 00:00:00
abstract::Ribosomal RNA (rRNA) is most highly expressed in rapidly growing bacteria and is drastically downregulated under stress conditions by the global transcriptional regulator DksA and the alarmone ppGpp. Here, we determined cryo-electron microscopy structures of the Escherichia coli RNA polymerase (RNAP) σ70 holoenzyme du...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20776-y
更新日期:2021-01-22 00:00:00
abstract::Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk. We explore the relationship between lipid and glucose control by con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20750-8
更新日期:2021-01-22 00:00:00
abstract::Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. We previously demonstrated that transcription factors GATA2 and MITF are the mast cell lineage-determining factors. However, it is unclear whether these lineage-determining factors regulate chromatin accessibility a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20766-0
更新日期:2021-01-21 00:00:00
abstract::Motile plant structures such as Mimosa pudica leaves, Impatiens glandulifera seedpods, and Dionaea muscipula leaves exhibit fast nastic movements in a few seconds or less. This motion is stimuli-independent mechanical movement following theorema egregium rules. Artificial analogs of tropistic motion in plants are exem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20843-4
更新日期:2021-01-21 00:00:00
abstract::Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20847-0
更新日期:2021-01-21 00:00:00
abstract::Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20796-8
更新日期:2021-01-21 00:00:00
abstract::Stability is now a critical factor in the commercialization of organic photovoltaic (OPV) devices. Both extrinsic stability to oxygen and water and intrinsic stability to light and heat in inert conditions must be achieved. Triplet states are known to be problematic in both cases, leading to singlet oxygen production ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20601-6
更新日期:2021-01-20 00:00:00
abstract::Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localizat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20735-7
更新日期:2021-01-20 00:00:00
abstract::SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus maturation, dysregulation of host inflammation, and antiviral immune responses. The multiple functions of PLpro render it a promising drug targe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20718-8
更新日期:2021-01-20 00:00:00
abstract::Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that antibody cocktails prevent viral escape remain unclear. We compared the critical residues in the receptor-binding domain (RBD) used by multiple neutralizing antibo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20789-7
更新日期:2021-01-20 00:00:00
abstract::The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20685-0
更新日期:2021-01-19 00:00:00
abstract::Express delivery services are booming in both developed and emerging economies due to their low cost, convenience, and the fast growth in online shopping. The increasing environmental impacts of express delivery services and mitigation potentials, however, remain largely unexplored. Here we addressed such a gap for Ch...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20738-4
更新日期:2021-01-19 00:00:00
abstract::Some Bacteroidetes and other human colonic bacteria can degrade arabinoxylans, common polysaccharides found in dietary fiber. Previous work has identified gene clusters (polysaccharide-utilization loci, PULs) for degradation of simple arabinoxylans. However, the degradation of complex arabinoxylans (containing side ch...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20737-5
更新日期:2021-01-19 00:00:00
abstract::Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic integrated frequency combs (soliton microcombs) have enabled t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20404-9
更新日期:2021-01-18 00:00:00
abstract::Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20715-x
更新日期:2021-01-18 00:00:00
abstract::Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perform transcription or tran...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20479-4
更新日期:2021-01-15 00:00:00
abstract::Spinal cord injury (SCI) often causes severe and permanent disabilities due to the regenerative failure of severed axons. Here we report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20112-4
更新日期:2021-01-15 00:00:00
abstract::The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and cyber-physical system integrations. Novel applications of 'bio-informational' engineering will arise in environmental monitorin...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-20764-2
更新日期:2021-01-15 00:00:00
abstract::Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate in plants. Here, we kinetically and mechanistically describe the non-reducing-end xylose-releasing exo-oligoxylanase activity and report the crystal structure of a native ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20620-3
更新日期:2021-01-14 00:00:00