Abstract:
:Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. We previously demonstrated that transcription factors GATA2 and MITF are the mast cell lineage-determining factors. However, it is unclear whether these lineage-determining factors regulate chromatin accessibility at mast cell enhancer regions. In this study, we demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation. We find that the number and densities of GATA2- but not MITF-bound sites at the super-enhancers are several folds higher than that at the typical enhancers. Our studies reveal that GATA2 promotes robust gene transcription to maintain mast cell identity and respond to antigenic stimulation by binding to super-enhancer regions with dense GATA2 binding sites available at key mast cell genes.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Li Y,Gao J,Kamran M,Harmacek L,Danhorn T,Leach SM,O'Connor BP,Hagman JR,Huang Hdoi
10.1038/s41467-020-20766-0subject
Has Abstractpub_date
2021-01-21 00:00:00pages
494issue
1issn
2041-1723pii
10.1038/s41467-020-20766-0journal_volume
12pub_type
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