Abstract:
:Some Bacteroidetes and other human colonic bacteria can degrade arabinoxylans, common polysaccharides found in dietary fiber. Previous work has identified gene clusters (polysaccharide-utilization loci, PULs) for degradation of simple arabinoxylans. However, the degradation of complex arabinoxylans (containing side chains such as ferulic acid, a phenolic compound) is poorly understood. Here, we identify a PUL that encodes multiple esterases for degradation of complex arabinoxylans in Bacteroides species. The PUL is specifically upregulated in the presence of complex arabinoxylans. We characterize some of the esterases biochemically and structurally, and show that they release ferulic acid from complex arabinoxylans. Growth of four different colonic Bacteroidetes members, including Bacteroides intestinalis, on complex arabinoxylans results in accumulation of ferulic acid, a compound known to have antioxidative and immunomodulatory properties.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Pereira GV,Abdel-Hamid AM,Dutta S,D'Alessandro-Gabazza CN,Wefers D,Farris JA,Bajaj S,Wawrzak Z,Atomi H,Mackie RI,Gabazza EC,Shukla D,Koropatkin NM,Cann Idoi
10.1038/s41467-020-20737-5subject
Has Abstractpub_date
2021-01-19 00:00:00pages
459issue
1issn
2041-1723pii
10.1038/s41467-020-20737-5journal_volume
12pub_type
杂志文章abstract::Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08775-0
更新日期:2019-02-20 00:00:00
abstract::MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, competitive ability ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02149-0
更新日期:2017-12-12 00:00:00
abstract::Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription could elicit their instability; however, the underlying mechanisms remain elusive. Genome-wide...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13674-5
更新日期:2019-12-13 00:00:00
abstract::Pseudomonas aeruginosa, an opportunistic pathogen of humans, uses quorum sensing (QS) to regulate the production of extracellular products that can benefit all members of the population. P. aeruginosa can police QS-deficient cheaters by producing hydrogen cyanide, which is also QS regulated; however, the mechanism by ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13013-8
更新日期:2019-11-01 00:00:00
abstract::Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to understand the mechan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06221-1
更新日期:2018-09-18 00:00:00
abstract::The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10489
更新日期:2016-02-04 00:00:00
abstract::Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2204
更新日期:2012-01-01 00:00:00
abstract::Electrodynamic responses from three-dimensional topological insulators are characterized by the universal magnetoelectric term constituent of the Lagrangian formalism. The quantized magnetoelectric coupling, which is generally referred to as topological magnetoelectric effect, has been predicted to induce exotic pheno...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12245
更新日期:2016-07-20 00:00:00
abstract::Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9009
更新日期:2015-08-18 00:00:00
abstract::Potassium ion channels utilize a highly selective filter to rapidly transport K+ ions across cellular membranes. This selectivity filter is composed of four binding sites which display almost equal electron density in crystal structures with high potassium ion concentrations. This electron density can be interpreted t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06957-w
更新日期:2018-10-31 00:00:00
abstract::The original version of this Article contained errors in Figures 1 and 3. In Fig. 1b, the label 'IP-PBP3' above the second of the three blots incorrectly read 'IP-PBP1B'. In Fig. 3b, the label 'PBP1B' under the first bar of each chart incorrectly read 'PBP1A'. These errors have been corrected in both the PDF and HTML ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-019-08410-y
更新日期:2019-01-30 00:00:00
abstract::A number of marine organisms use muscle-controlled surface structures to achieve rapid changes in colour and transparency with outstanding reversibility. Inspired by these display tactics, we develop analogous deformation-controlled surface-engineering approaches via strain-dependent cracks and folds to realize the fo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11802
更新日期:2016-07-08 00:00:00
abstract::Viruses cause 10-15% of all human cancers. Massively parallel sequencing has recently proved effective for uncovering novel viruses and virus-tumour associations, but this approach has not yet been applied to comprehensive patient cohorts. Here we screen a diverse landscape of human cancer, encompassing 4,433 tumours ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3513
更新日期:2013-01-01 00:00:00
abstract::The fate of the enormous amount of reactive nitrogen released to the environment by human activities in India is unknown. Here we show occurrence of seasonal stratification and generally low concentrations of dissolved inorganic combined nitrogen, and high molecular nitrogen (N2) to argon ratio, thus suggesting season...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03607-z
更新日期:2018-03-28 00:00:00
abstract::Carminic acid, a glucosylated anthraquinone found in scale insects like Dactylopius coccus, has since ancient times been used as a red colorant in various applications. Here we show that a membrane-bound C-glucosyltransferase, isolated from D. coccus and designated DcUGT2, catalyzes the glucosylation of flavokermesic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02031-z
更新日期:2017-12-07 00:00:00
abstract::Quantum magnets provide the simplest example of strongly interacting quantum matter, yet they continue to resist a comprehensive understanding above one spatial dimension. We explore a promising framework in two dimensions, the Dirac spin liquid (DSL) - quantum electrodynamics (QED3) with 4 Dirac fermions coupled to p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11727-3
更新日期:2019-09-18 00:00:00
abstract::Stimuli-responsive hydrogel actuators have promising applications in various fields. However, the typical hydrogel actuation relies on the swelling and de-swelling process caused by osmotic-pressure changes, which is slow and normally requires the presence of water environment. Herein, we report a light-powered in-air...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17775-4
更新日期:2020-08-10 00:00:00
abstract::Various platinum-free electrocatalysts have been explored for hydrogen evolution reaction in acidic solutions. However, in economical water-alkali electrolysers, sluggish water dissociation kinetics (Volmer step) on platinum-free electrocatalysts results in poor hydrogen-production activities. Here we report a MoNi4 e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15437
更新日期:2017-05-17 00:00:00
abstract::The immunogenic heat shock proteins (HSPs) gp96, hsp70 and calreticulin (CRT) bind to CD91 on antigen-presenting cells (APCs) for cross-presentation of the HSP-chaperoned peptides. This event leads to priming of T-cell responses. Here we show that CD91 serves as a signalling receptor for these HSPs, allowing for the m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1524
更新日期:2011-11-01 00:00:00
abstract::Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathw...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00758-3
更新日期:2017-09-21 00:00:00
abstract::The direct response of the tropical mixed layer to near-inertial waves (NIWs) has only rarely been observed. Here, we present upper-ocean turbulence data that provide evidence for a strongly elevated vertical diffusive heat flux across the base of the mixed layer in the presence of a NIW, thereby cooling the mixed lay...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17601-x
更新日期:2020-07-31 00:00:00
abstract::Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7416
更新日期:2015-04-02 00:00:00
abstract::There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11039-6
更新日期:2019-07-10 00:00:00
abstract::During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanica...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07448-8
更新日期:2018-11-27 00:00:00
abstract::Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show senescent tumour cells are frequently present in the front region of collective invasion of papillary thyroid carcinoma (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15208
更新日期:2017-05-10 00:00:00
abstract::Synthetic polymers are indispensable in many different applications, but there is a growing need for green processes and natural surfactants for emulsion polymerization. The use of solid particles to stabilize Pickering emulsions is a particularly attractive avenue, but oxygen sensitivity has remained a formidable cha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19407-3
更新日期:2020-11-05 00:00:00
abstract::Mangrove forests hold some of the highest densities of carbon recorded in any ecosystem, but have experienced widespread deforestation through conversion to aquaculture and agriculture. Alongside deforestation, mangroves have shown simultaneous natural expansion in some parts of the world, and considerable investments...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18118-z
更新日期:2020-08-26 00:00:00
abstract::Understanding lithospheric plate motions is of paramount importance to geodynamicists. Much effort is going into kinematic reconstructions featuring progressively finer temporal resolution. However, the challenge of precisely identifying ocean-floor magnetic lineations, and uncertainties in geomagnetic reversal timesc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2051
更新日期:2012-01-01 00:00:00
abstract::An incorrect version of the Supplementary Information was inadvertently published with this Article. The HTML has now been updated to include the correct version of the Supplementary Information. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-017-01617-x
更新日期:2017-11-23 00:00:00
abstract::Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but the generalizability of such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on the Illumina HumanExome Beadchip, in search ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3872
更新日期:2013-01-01 00:00:00