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Anomalous X-ray diffraction studies of ion transport in K+ channels.

Abstract：

:Potassium ion channels utilize a highly selective filter to rapidly transport K+ ions across cellular membranes. This selectivity filter is composed of four binding sites which display almost equal electron density in crystal structures with high potassium ion concentrations. This electron density can be interpreted to reflect a superposition of alternating potassium ion and water occupied states or as adjacent potassium ions. Here, we use single wavelength anomalous dispersion (SAD) X-ray diffraction data collected near the potassium absorption edge to show experimentally that all ion binding sites within the selectivity filter are fully occupied by K+ ions. These data support the hypothesis that potassium ion transport occurs by direct Coulomb knock-on, and provide an example of solving the phase problem by K-SAD.

journal_name

Nat Commun

journal_title

Nature communications

authors

Langan PS,Vandavasi VG,Weiss KL,Afonine PV,El Omari K,Duman R,Wagner A,Coates L

doi

10.1038/s41467-018-06957-w

subject

Has Abstract

pub_date

2018-10-31 00:00:00

pages

4540

issue

1

issn

2041-1723

pii

10.1038/s41467-018-06957-w

journal_volume

9

pub_type

杂志文章

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