Senescent tumor cells lead the collective invasion in thyroid cancer.

abstract：:5-Deoxyribose is formed from 5'-deoxyadenosine, a toxic byproduct of radical S-adenosylmethionine (SAM) enzymes. The degradative fate of 5-deoxyribose is unknown. Here, we define a salvage pathway for 5-deoxyribose in bacteria, consisting of phosphorylation, isomerization, and aldol cleavage steps. Analysis of bacteri...

journal_title：Nature communications

authors： Beaudoin GAW,Li Q,Folz J,Fiehn O,Goodsell JL,Angerhofer A,Bruner SD,Hanson AD

更新日期：2018-08-06 00:00:00

abstract：:The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Bowling S,Di Gregorio A,Sancho M,Pozzi S,Aarts M,Signore M,Schneider MD,Martinez-Barbera JP,Gil J,Rodríguez TA

更新日期：2018-08-02 00:00:00

abstract：:Since the 1970s, it has been known that black-hole (and other) horizons are truly thermodynamic. More generally, surfaces which are not horizons have also been conjectured to behave thermodynamically. Initially, for surfaces microscopically expanded from a horizon to so-called stretched horizons, and more recently, fo...

journal_title：Nature communications

authors： Wang ZW,Braunstein SL

更新日期：2018-07-30 00:00:00

abstract：:Voltage-gated sodium channels (Na(v)) underlie the rapid upstroke of action potentials in excitable tissues. Binding of channel-interactive proteins is essential for controlling fast and long-term inactivation. In the structure of the complex of the carboxy-terminal portion of Na(v)1.5 (CTNa(v)1.5) with calmodulin (Ca...

journal_title：Nature communications

authors： Gabelli SB,Boto A,Kuhns VH,Bianchet MA,Farinelli F,Aripirala S,Yoder J,Jakoncic J,Tomaselli GF,Amzel LM

更新日期：2014-11-05 00:00:00

abstract：:Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger body sizes than those observed at higher temperatures. The underlying molecular basis of this effect is poorly understood. Here we provide evidence that the temperature-dependent regulation of Drosoph...

journal_title：Nature communications

authors： Li Q,Gong Z

更新日期：2015-12-09 00:00:00

abstract：:The Satb1 genome organizer regulates multiple cellular and developmental processes. It is not yet clear how Satb1 selects different sets of targets throughout the genome. Here we have used live-cell single molecule imaging and deep sequencing to assess determinants of Satb1 binding-site selectivity. We have found that...

journal_title：Nature communications

authors： Ghosh RP,Shi Q,Yang L,Reddick MP,Nikitina T,Zhurkin VB,Fordyce P,Stasevich TJ,Chang HY,Greenleaf WJ,Liphardt JT

更新日期：2019-07-19 00:00:00

abstract：:Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage of COPI vesicle formation. Here, we find that PA with vary...

journal_title：Nature communications

authors： Park SY,Yang JS,Li Z,Deng P,Zhu X,Young D,Ericsson M,Andringa RLH,Minnaard AJ,Zhu C,Sun F,Moody DB,Morris AJ,Fan J,Hsu VW

更新日期：2019-07-30 00:00:00

abstract：:Among various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chr...

journal_title：Nature communications

authors： Wang S,Wu PC,Su VC,Lai YC,Hung Chu C,Chen JW,Lu SH,Chen J,Xu B,Kuan CH,Li T,Zhu S,Tsai DP

更新日期：2017-08-04 00:00:00

abstract：:Various promising qubit concepts have been put forward recently based on engineered superconductor subgap states like Andreev bound states, Majorana zero modes or the Yu-Shiba-Rusinov (Shiba) states. The coupling of these subgap states via a superconductor strongly depends on their spatial extension and is an essentia...

journal_title：Nature communications

authors： Scherübl Z,Fülöp G,Moca CP,Gramich J,Baumgartner A,Makk P,Elalaily T,Schönenberger C,Nygård J,Zaránd G,Csonka S

更新日期：2020-04-14 00:00:00

abstract：:Foxp3+ regulatory T (Treg) cells are essential for maintaining peripheral tolerance and preventing autoimmunity. While genetic factors may predispose for autoimmunity, additional environmental triggers, such as viral infections, are usually required to initiate the onset of disease. Here, we show that viral infection ...

journal_title：Nature communications

authors： Schorer M,Lambert K,Rakebrandt N,Rost F,Kao KC,Yermanos A,Spörri R,Oderbolz J,Raeber ME,Keller CW,Lünemann JD,Rogler G,Boyman O,Oxenius A,Joller N

更新日期：2020-03-23 00:00:00

abstract：:Two-dimensional transition metal carbides (MXenes) have attracted a great interest of the research community as a relatively recently discovered large class of materials with unique electronic and optical properties. Understanding of adhesion between MXenes and various substrates is critically important for MXene devi...

journal_title：Nature communications

authors： Li Y,Huang S,Wei C,Wu C,Mochalin VN

更新日期：2019-07-08 00:00:00

abstract：:At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic expression of the ...

journal_title：Nature communications

authors： Anton KA,Kajita M,Narumi R,Fujita Y,Tada M

更新日期：2018-11-08 00:00:00

abstract：:Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...

journal_title：Nature communications

authors： Mogg L,Zhang S,Hao GP,Gopinadhan K,Barry D,Liu BL,Cheng HM,Geim AK,Lozada-Hidalgo M

更新日期：2019-09-18 00:00:00

abstract：:Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...

journal_title：Nature communications

authors： Jiang Y,Qin C,Cui M,He T,Liu K,Huang Y,Luo M,Zhang L,Xu H,Li S,Wei J,Liu Z,Wang H,Kim GH,Yuan M,Chen J

更新日期：2019-04-23 00:00:00

abstract：:Pioneer transcription factors can engage nucleosomal DNA, which leads to local chromatin remodeling and to the establishment of transcriptional competence. However, the impact of enhancer priming by pioneer factors on the temporal control of gene expression and on mitotic memory remains unclear. Here we employ quantit...

journal_title：Nature communications

authors： Dufourt J,Trullo A,Hunter J,Fernandez C,Lazaro J,Dejean M,Morales L,Nait-Amer S,Schulz KN,Harrison MM,Favard C,Radulescu O,Lagha M

更新日期：2018-12-05 00:00:00

abstract：:Coupling vibrational transitions to resonant optical modes creates vibrational polaritons shifted from the uncoupled molecular resonances and provides a convenient way to modify the energetics of molecular vibrations. This approach is a viable method to explore controlling chemical reactivity. In this work, we report ...

journal_title：Nature communications

authors： Dunkelberger AD,Spann BT,Fears KP,Simpkins BS,Owrutsky JC

更新日期：2016-11-22 00:00:00

abstract：:The efficiencies of perovskite solar cells (PSCs) are now reaching such consistently high levels that scalable manufacturing at low cost is becoming critical. However, this remains challenging due to the expensive hole-transporting materials usually employed, and difficulties associated with the scalable deposition of...

journal_title：Nature communications

authors： Wu WQ,Wang Q,Fang Y,Shao Y,Tang S,Deng Y,Lu H,Liu Y,Li T,Yang Z,Gruverman A,Huang J

更新日期：2018-04-24 00:00:00

abstract：:Visualizing the rearrangement of atoms in a wide range of molecular and condensed-matter systems requires resolving picometre displacements on a 10-fs timescale, which is achievable using pump-probe diffraction, given short enough pulses. Here we demonstrate the compression of single-electron pulses with a de Broglie ...

journal_title：Nature communications

authors： Gliserin A,Walbran M,Krausz F,Baum P

更新日期：2015-10-27 00:00:00

abstract：:Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...

journal_title：Nature communications

authors： Nilsson Pingel T,Jørgensen M,Yankovich AB,Grönbeck H,Olsson E

更新日期：2018-07-13 00:00:00

abstract：:Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use...

journal_title：Nature communications

authors： Woo CW,Schmidt L,Krishnan A,Jepma M,Roy M,Lindquist MA,Atlas LY,Wager TD

更新日期：2017-02-14 00:00:00

abstract：:For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemb...

journal_title：Nature communications

authors： Laine VN,Gossmann TI,Schachtschneider KM,Garroway CJ,Madsen O,Verhoeven KJ,de Jager V,Megens HJ,Warren WC,Minx P,Crooijmans RP,Corcoran P,Great Tit HapMap Consortium.,Sheldon BC,Slate J,Zeng K,van Oers K,Visser ME,Gro

更新日期：2016-01-25 00:00:00

abstract：:Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar 'Canthatch' suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-s...

journal_title：Nature communications

authors： Hiebert CW,Moscou MJ,Hewitt T,Steuernagel B,Hernández-Pinzón I,Green P,Pujol V,Zhang P,Rouse MN,Jin Y,McIntosh RA,Upadhyaya N,Zhang J,Bhavani S,Vrána J,Karafiátová M,Huang L,Fetch T,Doležel J,Wulff BBH,Lagudah E,

更新日期：2020-02-28 00:00:00

abstract：:TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3. Here, we report that activation of DR3 signaling by an agonistic anti-DR3 antibody incr...

journal_title：Nature communications

authors： Li J,Shi W,Sun H,Ji Y,Chen Y,Guo X,Sheng H,Shu J,Zhou L,Cai T,Qiu J

更新日期：2019-07-29 00:00:00

abstract：:Engineering intramolecular exchange interactions between magnetic metal atoms is a ubiquitous strategy for designing molecular magnets. For lanthanides, the localized nature of 4f electrons usually results in weak exchange coupling. Mediating magnetic interactions between lanthanide ions via radical bridges is a fruit...

journal_title：Nature communications

authors： Liu F,Velkos G,Krylov DS,Spree L,Zalibera M,Ray R,Samoylova NA,Chen CH,Rosenkranz M,Schiemenz S,Ziegs F,Nenkov K,Kostanyan A,Greber T,Wolter AUB,Richter M,Büchner B,Avdoshenko SM,Popov AA

更新日期：2019-02-04 00:00:00

abstract：:Synthetic DNA is becoming an attractive substrate for digital data storage due to its density, durability, and relevance in biological research. A major challenge in making DNA data storage a reality is that reading DNA back into data using sequencing by synthesis remains a laborious, slow and expensive process. Here,...

journal_title：Nature communications

authors： Lopez R,Chen YJ,Dumas Ang S,Yekhanin S,Makarychev K,Racz MZ,Seelig G,Strauss K,Ceze L

更新日期：2019-07-03 00:00:00

abstract：:Infrared light detection and sensing is deeply embedded in modern technology and human society and its development has always been benefitting from the discovery of various photoelectric materials. The rise of two-dimensional materials, thanks to their distinct electronic structures, extreme dimensional confinement an...

journal_title：Nature communications

authors： Yin J,Tan Z,Hong H,Wu J,Yuan H,Liu Y,Chen C,Tan C,Yao F,Li T,Chen Y,Liu Z,Liu K,Peng H

更新日期：2018-08-17 00:00:00

abstract：:Redox-regulated effector systems that counteract oxidative stress are essential for all forms of life. Here we uncover a new paradigm for sensing oxidative stress centred on the hydrophobic core of a sensor protein. RsrA is an archetypal zinc-binding anti-sigma factor that responds to disulfide stress in the cytoplasm...

journal_title：Nature communications

authors： Rajasekar KV,Zdanowski K,Yan J,Hopper JT,Francis ML,Seepersad C,Sharp C,Pecqueur L,Werner JM,Robinson CV,Mohammed S,Potts JR,Kleanthous C

更新日期：2016-07-19 00:00:00

abstract：:Discharge from sliding outlet glaciers controls uncertainty in projections for future sea level. Remarkably, over 90% of glacial area is subject to gravitational driving stresses below 150 kPa (median ∼70 kPa). Longstanding explanations that appeal to the shear-thinning rheology of ice tend to overpredict driving stre...

journal_title：Nature communications

authors： Meyer CR,Downey AS,Rempel AW

更新日期：2018-08-13 00:00:00

abstract：:As an in-plane charge current flows in a heavy metal film with spin-orbit coupling, it produces a torque on and thereby switches the magnetization in a neighbouring ferromagnetic metal film. Such spin-orbit torque (SOT)-induced switching has been studied extensively in recent years and has shown higher efficiency than...

journal_title：Nature communications

authors： Li P,Liu T,Chang H,Kalitsov A,Zhang W,Csaba G,Li W,Richardson D,DeMann A,Rimal G,Dey H,Jiang JS,Porod W,Field SB,Tang J,Marconi MC,Hoffmann A,Mryasov O,Wu M

更新日期：2016-09-01 00:00:00

abstract：:The investigations on optical angular momenta and their interactions have broadened our knowledge of light's behavior at sub-wavelength scales. Recent studies further unveil the extraordinary characteristics of transverse spin angular momentum in confined light fields and orbital angular momentum in optical vortices. ...

journal_title：Nature communications

authors： Shao Z,Zhu J,Chen Y,Zhang Y,Yu S

更新日期：2018-03-02 00:00:00