当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide.

Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide.

Abstract：

:Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription could elicit their instability; however, the underlying mechanisms remain elusive. Genome-wide replication timing analyses here show that stress-induced delayed/under-replication is the hallmark of CFSs. Extensive genome-wide analyses of nascent transcripts, replication origin positioning and fork directionality reveal that 80% of CFSs nest in large transcribed domains poor in initiation events, replicated by long-travelling forks. Forks that travel long in late S phase explains CFS replication features, whereas formation of sequence-dependent fork barriers or head-on transcription-replication conflicts do not. We further show that transcription inhibition during S phase, which suppresses transcription-replication encounters and prevents origin resetting, could not rescue CFS stability. Altogether, our results show that transcription-dependent suppression of initiation events delays replication of large gene bodies, committing them to instability.

journal_name

Nat Commun

journal_title

Nature communications

authors

Brison O,El-Hilali S,Azar D,Koundrioukoff S,Schmidt M,Nähse V,Jaszczyszyn Y,Lachages AM,Dutrillaux B,Thermes C,Debatisse M,Chen CL

doi

10.1038/s41467-019-13674-5

subject

Has Abstract

pub_date

2019-12-13 00:00:00

pages

5693

issue

1

issn

2041-1723

pii

10.1038/s41467-019-13674-5

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Nanosecond electron pulses in the analytical electron microscopy of a fast irreversible chemical reaction.

    abstract：:We show how the kinetics of a fast and irreversible chemical reaction in a nanocrystalline material at high temperature can be studied using nanosecond electron pulses in an electron microscope. Infrared laser pulses first heat a nanocrystalline oxide layer on a carbon film, then single nanosecond electron pulses allo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11669-w

    authors： Sinha SK,Khammari A,Picher M,Roulland F,Viart N,LaGrange T,Banhart F

    更新日期：2019-08-13 00:00:00

  • Spatially selective manipulation of cells with single-beam acoustical tweezers.

    abstract：:Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equivalent ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18000-y

    authors： Baudoin M,Thomas JL,Sahely RA,Gerbedoen JC,Gong Z,Sivery A,Matar OB,Smagin N,Favreau P,Vlandas A

    更新日期：2020-08-25 00:00:00

  • Dereplication of microbial metabolites through database search of mass spectra.

    abstract：:Natural products have traditionally been rich sources for drug discovery. In order to clear the road toward the discovery of unknown natural products, biologists need dereplication strategies that identify known ones. Here we report DEREPLICATOR+, an algorithm that improves on the previous approaches for identifying p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06082-8

    authors： Mohimani H,Gurevich A,Shlemov A,Mikheenko A,Korobeynikov A,Cao L,Shcherbin E,Nothias LF,Dorrestein PC,Pevzner PA

    更新日期：2018-10-02 00:00:00

  • Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain.

    abstract：:Experimental and modeling work of neural activity has described recurrent and attractor dynamic patterns in cerebral microcircuits. However, it is still poorly understood whether similar dynamic principles exist or can be generalizable to the large-scale level. Here, we applied dynamic graph theory-based analyses to e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06346-3

    authors： Diez I,Sepulcre J

    更新日期：2018-09-24 00:00:00

  • Two-dimensional metallic tantalum disulfide as a hydrogen evolution catalyst.

    abstract：:Two-dimensional metallic transition metal dichalcogenides are emerging as prototypes for uncovering fundamental physical phenomena, such as superconductivity and charge-density waves, as well as for engineering-related applications. However, the batch production of such envisioned transition metal dichalcogenides rema...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01089-z

    authors： Shi J,Wang X,Zhang S,Xiao L,Huan Y,Gong Y,Zhang Z,Li Y,Zhou X,Hong M,Fang Q,Zhang Q,Liu X,Gu L,Liu Z,Zhang Y

    更新日期：2017-10-16 00:00:00

  • Topological phase transitions and chiral inelastic transport induced by the squeezing of light.

    abstract：:There is enormous interest in engineering topological photonic systems. Despite intense activity, most works on topological photonic states (and more generally bosonic states) amount in the end to replicating a well-known fermionic single-particle Hamiltonian. Here we show how the squeezing of light can lead to the fo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10779

    authors： Peano V,Houde M,Brendel C,Marquardt F,Clerk AA

    更新日期：2016-03-02 00:00:00

  • Iron limitation of microbial phosphorus acquisition in the tropical North Atlantic.

    abstract：:In certain regions of the predominantly nitrogen limited ocean, microbes can become co-limited by phosphorus. Within such regions, a proportion of the dissolved organic phosphorus pool can be accessed by microbes employing a variety of alkaline phosphatase (APase) enzymes. In contrast to the PhoA family of APases that...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15465

    authors： Browning TJ,Achterberg EP,Yong JC,Rapp I,Utermann C,Engel A,Moore CM

    更新日期：2017-05-19 00:00:00

  • Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration.

    abstract：:Prostate development depends on balanced cell proliferation and differentiation, and acetylated KLF5 is known to alter epithelial proliferation. It remains elusive whether post-translational modifications of transcription factors can differentially determine adult stem/progenitor cell fate. Here we report that, in hum...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14737-8

    authors： Zhang B,Ci X,Tao R,Ni JJ,Xuan X,King JL,Xia S,Li Y,Frierson HF,Lee DK,Xu J,Osunkoya AO,Dong JT

    更新日期：2020-02-21 00:00:00

  • Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma.

    abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06354-3

    authors： Arthur SE,Jiang A,Grande BM,Alcaide M,Cojocaru R,Rushton CK,Mottok A,Hilton LK,Lat PK,Zhao EY,Culibrk L,Ennishi D,Jessa S,Chong L,Thomas N,Pararajalingam P,Meissner B,Boyle M,Davidson J,Bushell KR,Lai D,Farinha

    更新日期：2018-10-01 00:00:00

  • Spin-dependent charge transfer state design rules in organic photovoltaics.

    abstract：:Charge transfer states play a crucial role in organic photovoltaics, mediating both photocurrent generation and recombination losses. In this work, we examine recombination losses as a function of the electron-hole spacing in fluorescent charge transfer states, including direct monitoring of both singlet and triplet c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7415

    authors： Chang W,Congreve DN,Hontz E,Bahlke ME,McMahon DP,Reineke S,Wu TC,Bulović V,Van Voorhis T,Baldo MA

    更新日期：2015-03-12 00:00:00

  • Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.

    abstract：:Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapidly metabolized and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02776-7

    authors： Gray DL,Allen JA,Mente S,O'Connor RE,DeMarco GJ,Efremov I,Tierney P,Volfson D,Davoren J,Guilmette E,Salafia M,Kozak R,Ehlers MD

    更新日期：2018-02-14 00:00:00

  • Selective and low temperature transition metal intercalation in layered tellurides.

    abstract：:Layered materials embrace rich intercalation reactions to accommodate high concentrations of foreign species within their structures, and find many applications spanning from energy storage, ion exchange to secondary batteries. Light alkali metals are generally most easily intercalated due to their light mass, high ch...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13809

    authors： Yajima T,Koshiko M,Zhang Y,Oguchi T,Yu W,Kato D,Kobayashi Y,Orikasa Y,Yamamoto T,Uchimoto Y,Green MA,Kageyama H

    更新日期：2016-12-14 00:00:00

  • Confinement-deconfinement transition due to spontaneous symmetry breaking in quantum Hall bilayers.

    abstract：:Band-inverted electron-hole bilayers support quantum spin Hall insulator and exciton condensate phases. Interest in quantum spin Hall effect in these systems has recently put them in the spotlight. We investigate such a bilayer in an external magnetic field. We show that the interlayer correlations lead to formation o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10462

    authors： Pikulin DI,Silvestrov PG,Hyart T

    更新日期：2016-01-25 00:00:00

  • Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC.

    abstract：:In the enteric pathogen Salmonella enterica serovar Typhimurium, invasion and motility are coordinated by the master regulator HilD, which induces expression of the type III secretion system 1 (T3SS1) and motility genes. Methyl-accepting chemotaxis proteins (MCPs) detect specific ligands and control the direction of t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20558-6

    authors： Cooper KG,Chong A,Kari L,Jeffrey B,Starr T,Martens C,McClurg M,Posada VR,Laughlin RC,Whitfield-Cargile C,Garry Adams L,Bryan LK,Little SV,Krath M,Lawhon SD,Steele-Mortimer O

    更新日期：2021-01-13 00:00:00

  • MPIase is a glycolipozyme essential for membrane protein integration.

    abstract：:Protein integration into biological membranes is a vital cellular event for all organisms. We previously reported an integration factor in the inner membrane of Escherichia coli, named MPIase (membrane protein integrase). Here we show that in contrast to previously identified integration factors that are proteins, MPI...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2267

    authors： Nishiyama K,Maeda M,Yanagisawa K,Nagase R,Komura H,Iwashita T,Yamagaki T,Kusumoto S,Tokuda H,Shimamoto K

    更新日期：2012-01-01 00:00:00

  • Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.

    abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20822-9

    authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

    更新日期：2021-01-28 00:00:00

  • Disclosing the temperature of columnar jointing in lavas.

    abstract：:Columnar joints form by cracking during cooling-induced contraction of lava, allowing hydrothermal fluid circulation. A lack of direct observations of their formation has led to ambiguity about the temperature window of jointing and its impact on fluid flow. Here we develop a novel thermo-mechanical experiment to disc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03842-4

    authors： Lamur A,Lavallée Y,Iddon FE,Hornby AJ,Kendrick JE,von Aulock FW,Wadsworth FB

    更新日期：2018-04-12 00:00:00

  • Pressure-stabilized lithium caesides with caesium anions beyond the -1 state.

    abstract：:Main group elements usually assume a typical oxidation state while forming compounds with other species. Group I elements are usually in the +1 state in inorganic materials. Our recent work reveals that pressure may make the inner shell 5p electrons of Cs reactive, causing Cs to expand beyond the +1 oxidation state. H...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5861

    authors： Botana J,Miao MS

    更新日期：2014-09-10 00:00:00

  • Accelerated sintering in phase-separating nanostructured alloys.

    abstract：:Sintering of powders is a common means of producing bulk materials when melt casting is impossible or does not achieve a desired microstructure, and has long been pursued for nanocrystalline materials in particular. Acceleration of sintering is desirable to lower processing temperatures and times, and thus to limit un...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7858

    authors： Park M,Schuh CA

    更新日期：2015-04-22 00:00:00

  • Bony cranial ornamentation linked to rapid evolution of gigantic theropod dinosaurs.

    abstract：:Exaggerated cranial structures such as crests and horns, hereafter referred to collectively as ornaments, are pervasive across animal species. These structures perform vital roles in visual communication and physical interactions within and between species. Yet the origin and influence of ornamentation on speciation a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12931

    authors： Gates TA,Organ C,Zanno LE

    更新日期：2016-09-27 00:00:00

  • NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli.

    abstract：:RNAs contain post-transcriptional modifications, which fulfill a variety of functions in translation, secondary structure stabilization and cellular stress survival. Here, 2-methylthiocytidine (ms2C) is identified in tRNA of E. coli and P. aeruginosa using NAIL-MS (nucleic acid isotope labeling coupled mass spectromet...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13565-9

    authors： Reichle VF,Petrov DP,Weber V,Jung K,Kellner S

    更新日期：2019-12-06 00:00:00

  • TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster.

    abstract：:Translationally controlled tumour protein (TCTP) is implicated in growth regulation and cancer. Recently, human TCTP has been suggested to play a role in the DNA damage response by forming a complex with ataxia telangiectasia-mutated (ATM) kinase . However, the exact nature of this interaction and its roles in vivo re...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3986

    authors： Hong ST,Choi KW

    更新日期：2013-01-01 00:00:00

  • Immunological and inflammatory profiles in mild and severe cases of COVID-19.

    abstract：:COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymph...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17240-2

    authors： Song JW,Zhang C,Fan X,Meng FP,Xu Z,Xia P,Cao WJ,Yang T,Dai XP,Wang SY,Xu RN,Jiang TJ,Li WG,Zhang DW,Zhao P,Shi M,Agrati C,Ippolito G,Maeurer M,Zumla A,Wang FS,Zhang JY

    更新日期：2020-07-08 00:00:00

  • Conformational gating of DNA conductance.

    abstract：:DNA is a promising molecule for applications in molecular electronics because of its unique electronic and self-assembly properties. Here we report that the conductance of DNA duplexes increases by approximately one order of magnitude when its conformation is changed from the B-form to the A-form. This large conductan...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9870

    authors： Artés JM,Li Y,Qi J,Anantram MP,Hihath J

    更新日期：2015-12-09 00:00:00

  • Layer-by-layer biofunctionalization of nanostructured porous silicon for high-sensitivity and high-selectivity label-free affinity biosensing.

    abstract：:Nanostructured materials premise to revolutionize the label-free biosensing of analytes for clinical applications, leveraging the deeper interaction between materials and analytes with comparable size. However, when the characteristic dimension of the materials reduces to the nanoscale, the surface functionalization f...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07723-8

    authors： Mariani S,Robbiano V,Strambini LM,Debrassi A,Egri G,Dähne L,Barillaro G

    更新日期：2018-12-10 00:00:00

  • Improved polygenic prediction by Bayesian multiple regression on summary statistics.

    abstract：:Accurate prediction of an individual's phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from genome-wide association studies (GWAS), SBayesR. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12653-0

    authors： Lloyd-Jones LR,Zeng J,Sidorenko J,Yengo L,Moser G,Kemper KE,Wang H,Zheng Z,Magi R,Esko T,Metspalu A,Wray NR,Goddard ME,Yang J,Visscher PM

    更新日期：2019-11-08 00:00:00

  • Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.

    abstract：:Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insu...

    journal_title：Nature communications

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41467-020-15963-w

    authors： Seo JA,Kang MC,Yang WM,Hwang WM,Kim SS,Hong SH,Heo JI,Vijyakumar A,Pereira de Moura L,Uner A,Huang H,Lee SH,Lima IS,Park KS,Kim MS,Dagon Y,Willnow TE,Aroda V,Ciaraldi TP,Henry RR,Kim YB

    更新日期：2020-04-24 00:00:00

  • Time-compressed preplay of anticipated events in human primary visual cortex.

    abstract：:Perception is guided by the anticipation of future events. It has been hypothesized that this process may be implemented by pattern completion in early visual cortex, in which a stimulus sequence is recreated after only a subset of the visual input is provided. Here we test this hypothesis using ultra-fast functional ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15276

    authors： Ekman M,Kok P,de Lange FP

    更新日期：2017-05-23 00:00:00

  • Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus.

    abstract：:Cryptochrome (Cry) 1 and Cry2 are regarded as critical components for circadian rhythm generation in mammals. Nevertheless, cultured suprachiasmatic nucleus (SCN) of neonatal Cry double deficient (Cry1(-/-)/Cry2(-/-)) mice exhibit circadian rhythms that damp out in several cycles. Here, by combining bioluminescence im...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2670

    authors： Ono D,Honma S,Honma K

    更新日期：2013-01-01 00:00:00

  • Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle.

    abstract：:The functional role of adult neurogenesis in the hippocampus remains the subject of intense speculation. One recent hypothesis is that adult-born neurons contribute to the endocrine and behavioural outputs of the stress response. Here we show a genetic model system to ablate neurogenesis by inducibly deleting Tbr2 gen...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9373

    authors： Tsai CY,Tsai CY,Arnold SJ,Huang GJ

    更新日期：2015-09-29 00:00:00