Abstract:
:COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Song JW,Zhang C,Fan X,Meng FP,Xu Z,Xia P,Cao WJ,Yang T,Dai XP,Wang SY,Xu RN,Jiang TJ,Li WG,Zhang DW,Zhao P,Shi M,Agrati C,Ippolito G,Maeurer M,Zumla A,Wang FS,Zhang JYdoi
10.1038/s41467-020-17240-2subject
Has Abstractpub_date
2020-07-08 00:00:00pages
3410issue
1issn
2041-1723pii
10.1038/s41467-020-17240-2journal_volume
11pub_type
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