Nanosecond electron pulses in the analytical electron microscopy of a fast irreversible chemical reaction.

abstract：:14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally con...

journal_title：Nature communications

authors： Le TP,Vuong LT,Kim AR,Hsu YC,Choi KW

更新日期：2016-05-06 00:00:00

abstract：:Rosemary extracts containing the phenolic diterpenes carnosic acid and its derivative carnosol are approved food additives used in an increasingly wide range of products to enhance shelf-life, thanks to their high anti-oxidant activity. We describe here the elucidation of the complete biosynthetic pathway of carnosic ...

journal_title：Nature communications

authors： Scheler U,Brandt W,Porzel A,Rothe K,Manzano D,Božić D,Papaefthimiou D,Balcke GU,Henning A,Lohse S,Marillonnet S,Kanellis AK,Ferrer A,Tissier A

更新日期：2016-10-05 00:00:00

abstract：:Metal ions can serve as a centre of molecular motions due to their coordination geometry, reversible bonding nature and external stimuli responsiveness. Such essential features of metal ions have been utilized for metal-mediated molecular machines with the ability to motion switch via metallation/demetallation or coor...

journal_title：Nature communications

authors： Ube H,Yasuda Y,Sato H,Shionoya M

更新日期：2017-02-08 00:00:00

abstract：:Autophagy-mediated degradation of mitochondria (mitophagy) is a key process in cellular quality control. Although mitophagy impairment is involved in several patho-physiological conditions, valuable methods to induce mitophagy with low toxicity in vivo are still lacking. Herein, we describe a new optogenetic tool to s...

journal_title：Nature communications

authors： D'Acunzo P,Strappazzon F,Caruana I,Meneghetti G,Di Rita A,Simula L,Weber G,Del Bufalo F,Dalla Valle L,Campello S,Locatelli F,Cecconi F

更新日期：2019-04-04 00:00:00

abstract：:We previously reported children homozygous for two MC3R sequence variants (C17A+G241A) have greater fat mass than controls. Here we show, using homozygous knock-in mouse models in which we replace murine Mc3r with wild-type human (MC3R(hWT/hWT)) and double-mutant (C17A+G241A) human (MC3R(hDM/hDM)) MC3R, that MC3R(hDM/...

journal_title：Nature communications

authors： Lee B,Koo J,Yun Jun J,Gavrilova O,Lee Y,Seo AY,Taylor-Douglas DC,Adler-Wailes DC,Chen F,Gardner R,Koutzoumis D,Sherafat Kazemzadeh R,Roberson RB,Yanovski JA

更新日期：2016-01-28 00:00:00

abstract：:Homologous recombination-mediated gene targeting has greatly contributed to genetic analysis in a wide range of species, but is highly inefficient in human cells because of overwhelmingly frequent random integration events, whose molecular mechanism remains elusive. Here we show that DNA polymerase θ, despite its mino...

journal_title：Nature communications

authors： Saito S,Maeda R,Adachi N

更新日期：2017-07-11 00:00:00

abstract：:Myoblast fusion is an indispensable step for skeletal muscle development, postnatal growth, and regeneration. Myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein that mediates Toll-like receptors and interleukin-1 receptor signaling. Here we report a cell-autonomous role of MyD88 in the regu...

journal_title：Nature communications

authors： Hindi SM,Shin J,Gallot YS,Straughn AR,Simionescu-Bankston A,Hindi L,Xiong G,Friedland RP,Kumar A

更新日期：2017-11-20 00:00:00

abstract：:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...

journal_title：Nature communications

authors： Lorent JH,Diaz-Rohrer B,Lin X,Spring K,Gorfe AA,Levental KR,Levental I

更新日期：2018-05-01 00:00:00

abstract：:Energy affects every single individual and entity in the world. Therefore, it is crucial to precisely quantify the "price of energy" and study how it evolves through time, through major political and social events, and through changes in energy and monetary policies. Here, we develop a predictive framework, an index t...

journal_title：Nature communications

authors： Baratsas SG,Niziolek AM,Onel O,Matthews LR,Floudas CA,Hallermann DR,Sorescu SM,Pistikopoulos EN

更新日期：2021-01-04 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:Tpt1 is an essential agent of fungal tRNA splicing that removes the 2'-PO4 at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique two-step reaction whereby the 2'-PO4 attacks NAD+ to form an RNA-2'-phospho-ADP-ribosyl intermediate that undergoes transesterification to yield 2'-OH RNA and ADP-r...

journal_title：Nature communications

authors： Banerjee A,Munir A,Abdullahu L,Damha MJ,Goldgur Y,Shuman S

更新日期：2019-01-15 00:00:00

abstract：:Short DNA linkers are increasingly being exploited for driving-specific self-assembly of Brownian objects. DNA-functionalized colloids can assemble into ordered or amorphous materials with tailored morphology. Recently, the same approach has been applied to compliant units, including emulsion droplets and lipid vesicl...

journal_title：Nature communications

authors： Parolini L,Mognetti BM,Kotar J,Eiser E,Cicuta P,Di Michele L

更新日期：2015-01-07 00:00:00

abstract：:Ultrashort optical pulses propagating in a dissipative nonlinear system can interact and bind stably, forming optical soliton molecules. Soliton molecules in ultrafast lasers are under intense research focus and present striking analogies with their matter molecules counterparts. The recent development of real-time sp...

journal_title：Nature communications

authors： Wang ZQ,Nithyanandan K,Coillet A,Tchofo-Dinda P,Grelu P

更新日期：2019-02-19 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) gen...

journal_title：Nature communications

authors： Lin Y,Nakatochi M,Hosono Y,Ito H,Kamatani Y,Inoko A,Sakamoto H,Kinoshita F,Kobayashi Y,Ishii H,Ozaka M,Sasaki T,Matsuyama M,Sasahira N,Morimoto M,Kobayashi S,Fukushima T,Ueno M,Ohkawa S,Egawa N,Kuruma S,Mori M,

更新日期：2020-06-24 00:00:00

abstract：:ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a synthetic lethal interaction with aurora kinase A (...

journal_title：Nature communications

authors： Wu C,Lyu J,Yang EJ,Liu Y,Zhang B,Shim JS

更新日期：2018-08-10 00:00:00

abstract：:Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of pan-resistant Gram-negative bacteria. Here, we show that mcr-1 confers resistance to colistin-induced lysis and bacterial cell death, but provides minimal protection from the ability of colistin to disrupt the Gram-negative oute...

journal_title：Nature communications

authors： MacNair CR,Stokes JM,Carfrae LA,Fiebig-Comyn AA,Coombes BK,Mulvey MR,Brown ED

更新日期：2018-01-31 00:00:00

abstract：:Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle con...

journal_title：Nature communications

authors： Gilfillan SMV,Györe D,Flude S,Johnson G,Bond CE,Hicks N,Lister R,Jones DG,Kremer Y,Haszeldine RS,Stuart FM

更新日期：2019-11-05 00:00:00

abstract：:Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic d...

journal_title：Nature communications

authors： Reza MM,Subramaniyam N,Sim CM,Ge X,Sathiakumar D,McFarlane C,Sharma M,Kambadur R

更新日期：2017-10-24 00:00:00

abstract：:Discharge from sliding outlet glaciers controls uncertainty in projections for future sea level. Remarkably, over 90% of glacial area is subject to gravitational driving stresses below 150 kPa (median ∼70 kPa). Longstanding explanations that appeal to the shear-thinning rheology of ice tend to overpredict driving stre...

journal_title：Nature communications

authors： Meyer CR,Downey AS,Rempel AW

更新日期：2018-08-13 00:00:00

abstract：:Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravita...

journal_title：Nature communications

authors： Fisher DT,Muhitch JB,Kim M,Doyen KC,Bogner PN,Evans SS,Skitzki JJ

更新日期：2016-02-17 00:00:00

abstract：:Vesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have sel...

journal_title：Nature communications

authors： Liu Y,Wang H,Li S,Chen C,Xu L,Huang P,Liu F,Su Y,Qi M,Yu C,Zhou Y

更新日期：2020-04-07 00:00:00

abstract：:Supercooling of aqueous solutions is a fundamentally and practically important physical phenomenon with numerous applications in biopreservation and beyond. Under normal conditions, heterogeneous nucleation mechanisms critically prohibit the simultaneous long-term (> 1 week), large volume (> 1 ml), and low temperature...

journal_title：Nature communications

authors： Huang H,Yarmush ML,Usta OB

更新日期：2018-08-10 00:00:00

abstract：:Following the discovery of high-temperature superconductivity in the La-H system, we studied the formation of new chemical compounds in the barium-hydrogen system at pressures from 75 to 173 GPa. Using in situ generation of hydrogen from NH3BH3, we synthesized previously unknown superhydride BaH12 with a pseudocubic (...

journal_title：Nature communications

authors： Chen W,Semenok DV,Kvashnin AG,Huang X,Kruglov IA,Galasso M,Song H,Duan D,Goncharov AF,Prakapenka VB,Oganov AR,Cui T

更新日期：2021-01-11 00:00:00

abstract：:Huntington's Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defec...

journal_title：Nature communications

authors： Gomez-Pastor R,Burchfiel ET,Neef DW,Jaeger AM,Cabiscol E,McKinstry SU,Doss A,Aballay A,Lo DC,Akimov SS,Ross CA,Eroglu C,Thiele DJ

更新日期：2017-02-13 00:00:00

abstract：:With the development of ultrafast electron and X-ray sources it is becoming possible to study structural dynamics with atomic-level spatial and temporal resolution. Because of their short mean free path, electrons are particularly well suited for investigating surfaces and thin films, such as the challenging and impor...

journal_title：Nature communications

authors： Engelen WJ,van der Heijden MA,Bakker DJ,Vredenbregt EJ,Luiten OJ

更新日期：2013-01-01 00:00:00

abstract：:Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, th...

journal_title：Nature communications

authors： Adachi K,Enoki T,Kawano Y,Veraz M,Nakai H

更新日期：2014-01-01 00:00:00

abstract：:Transmission-blocking interventions aim to reduce the prevalence of infection in endemic communities by targeting Plasmodium within the insect host. Although many studies have reported the successful reduction of infection in the mosquito vector, direct evidence that there is an onward reduction in infection in the ve...

journal_title：Nature communications

authors： Blagborough AM,Churcher TS,Upton LM,Ghani AC,Gething PW,Sinden RE

更新日期：2013-01-01 00:00:00

abstract：:The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca2+ dissipates the H+ gradient generated by ATP hydrolysis. Afte...

journal_title：Nature communications

authors： Urbani A,Giorgio V,Carrer A,Franchin C,Arrigoni G,Jiko C,Abe K,Maeda S,Shinzawa-Itoh K,Bogers JFM,McMillan DGG,Gerle C,Szabò I,Bernardi P

更新日期：2019-09-25 00:00:00

abstract：:Hollow-core fibre (HCF) is a powerful technology platform offering breakthrough performance improvements in sensing, communications, higher-power pulse delivery and other applications. Free from the usual constraints on what materials can guide light, it promises qualitatively new and ideal operating regimes: precisio...

journal_title：Nature communications

authors： Fini JM,Nicholson JW,Mangan B,Meng L,Windeler RS,Monberg EM,DeSantolo A,DiMarcello FV,Mukasa K

更新日期：2014-10-28 00:00:00

abstract：:Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these im...

journal_title：Nature communications

authors： Mu T,Wei B,Zhu D,Yu B

更新日期：2020-09-01 00:00:00