MPIase is a glycolipozyme essential for membrane protein integration.

abstract：:Mammals have nine different homologues (ALKBH1-9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive. It was recently shown that ALKBH8 contains an additional transfer RNA (tRNA) methyltransferase domain,...

journal_title：Nature communications

authors： van den Born E,Vågbø CB,Songe-Møller L,Leihne V,Lien GF,Leszczynska G,Malkiewicz A,Krokan HE,Kirpekar F,Klungland A,Falnes PØ

更新日期：2011-02-01 00:00:00

abstract：:Jasmonic acid (JA) is well known to promote lateral root formation but the mechanisms by which JA signalling is integrated into the pathways responsible for lateral root formation, and how it interacts with auxin in this process remains poorly understood. Here, we report that the highly JA-responsive ethylene response...

journal_title：Nature communications

authors： Cai XT,Xu P,Zhao PX,Liu R,Yu LH,Xiang CB

更新日期：2014-12-19 00:00:00

abstract：:The Montreal Protocol has succeeded in limiting major ozone-depleting substance emissions, and consequently stratospheric ozone concentrations are expected to recover this century. However, there is a large uncertainty in the rate of regional ozone recovery in the Northern Hemisphere. Here we identify a Eurasia-North ...

journal_title：Nature communications

authors： Zhang J,Tian W,Xie F,Chipperfield MP,Feng W,Son SW,Abraham NL,Archibald AT,Bekki S,Butchart N,Deushi M,Dhomse S,Han Y,Jöckel P,Kinnison D,Kirner O,Michou M,Morgenstern O,O'Connor FM,Pitari G,Plummer DA,Revell LE

更新日期：2018-01-15 00:00:00

abstract：:Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the transcription factor th...

journal_title：Nature communications

authors： Qi Y,Yu J,Han W,Fan X,Qian H,Wei H,Tsai YH,Zhao J,Zhang W,Liu Q,Meng S,Wang Y,Wang Z

更新日期：2016-06-13 00:00:00

abstract：:The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR) α-dependent DNA de...

journal_title：Nature communications

authors： Yuan X,Tsujimoto K,Hashimoto K,Kawahori K,Hanzawa N,Hamaguchi M,Seki T,Nawa M,Ehara T,Kitamura Y,Hatada I,Konishi M,Itoh N,Nakagawa Y,Shimano H,Takai-Igarashi T,Kamei Y,Ogawa Y

更新日期：2018-02-12 00:00:00

abstract：:Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology ar...

journal_title：Nature communications

authors： Spaan AN,Vrieling M,Wallet P,Badiou C,Reyes-Robles T,Ohneck EA,Benito Y,de Haas CJ,Day CJ,Jennings MP,Lina G,Vandenesch F,van Kessel KP,Torres VJ,van Strijp JA,Henry T

更新日期：2014-11-11 00:00:00

abstract：:Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...

journal_title：Nature communications

authors： Zhang Y,Huo Z,Wang X,Han X,Wu W,Wan B,Wang H,Zhai J,Tao J,Pan C,Wang ZL

更新日期：2020-11-06 00:00:00

abstract：:Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin-proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin-proteasome targets a...

journal_title：Nature communications

authors： Lignitto L,Arcella A,Sepe M,Rinaldi L,Delle Donne R,Gallo A,Stefan E,Bachmann VA,Oliva MA,Tiziana Storlazzi C,L'Abbate A,Brunetti A,Gargiulo S,Gramanzini M,Insabato L,Garbi C,Gottesman ME,Feliciello A

更新日期：2013-01-01 00:00:00

abstract：:The stratospheric Arctic vortex (SAV) plays a critical role in forecasting cold winters in northern mid-latitudes. Its influence on the tropospheric mid- and high-latitudes has attracted growing attention in recent years. However, the trend in the SAV during the recent two decades is still unknown. Here, using three r...

journal_title：Nature communications

authors： Hu D,Guan Z,Tian W,Ren R

更新日期：2018-04-27 00:00:00

abstract：:Neurons maintain axonal homeostasis via employing a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Abnormal MT-based trafficking hallmarks the pathology of neurodegenerative diseases, but the exact mechanism regulating MT dyna...

journal_title：Nature communications

authors： Negrete-Hurtado A,Overhoff M,Bera S,De Bruyckere E,Schätzmüller K,Kye MJ,Qin C,Lammers M,Kondylis V,Neundorf I,Kononenko NL

更新日期：2020-03-24 00:00:00

abstract：:Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...

journal_title：Nature communications

authors： Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H

更新日期：2020-12-10 00:00:00

abstract：:Interfacial issues commonly exist in solid-state batteries, and the microstructural complexity combines with the chemical heterogeneity to govern the local interfacial chemistry. The conventional wisdom suggests that "point-to-point" ion diffusion at the interface determines the ion transport kinetics. Here, we show t...

journal_title：Nature communications

authors： Lou S,Liu Q,Zhang F,Liu Q,Yu Z,Mu T,Zhao Y,Borovilas J,Chen Y,Ge M,Xiao X,Lee WK,Yin G,Yang Y,Sun X,Wang J

更新日期：2020-11-11 00:00:00

abstract：:The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...

journal_title：Nature communications

authors： Liu M,Lu Y,Yang B,Chen Y,Radda JSD,Hu M,Katz SG,Wang S

更新日期：2020-06-09 00:00:00

abstract：:There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...

journal_title：Nature communications

authors： Taylor JL,Debost JPG,Morton SU,Wigdor EM,Heyne HO,Lal D,Howrigan DP,Bloemendal A,Larsen JT,Kosmicki JA,Weiner DJ,Homsy J,Seidman JG,Seidman CE,Agerbo E,McGrath JJ,Mortensen PB,Petersen L,Daly MJ,Robinson EB

更新日期：2019-07-10 00:00:00

abstract：:CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate that Cep63-deficient mice recapitulate Seckel syndrome pathology. The attrition of...

journal_title：Nature communications

authors： Marjanović M,Sánchez-Huertas C,Terré B,Gómez R,Scheel JF,Pacheco S,Knobel PA,Martínez-Marchal A,Aivio S,Palenzuela L,Wolfrum U,McKinnon PJ,Suja JA,Roig I,Costanzo V,Lüders J,Stracker TH

更新日期：2015-07-09 00:00:00

abstract：:Laser powder bed fusion additive manufacturing is an emerging 3D printing technique for the fabrication of advanced metal components. Widespread adoption of it and similar additive technologies is hampered by poor understanding of laser-metal interactions under such extreme thermal regimes. Here, we elucidate the mech...

journal_title：Nature communications

authors： Martin AA,Calta NP,Khairallah SA,Wang J,Depond PJ,Fong AY,Thampy V,Guss GM,Kiss AM,Stone KH,Tassone CJ,Nelson Weker J,Toney MF,van Buuren T,Matthews MJ

更新日期：2019-04-30 00:00:00

abstract：:The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-un...

journal_title：Nature communications

authors： Cooch NK,Stalnaker TA,Wied HM,Bali-Chaudhary S,McDannald MA,Liu TL,Schoenbaum G

更新日期：2015-05-21 00:00:00

abstract：:A nest of begging chicks invites an intuitive explanation: needy chicks want to be fed and parents want to feed them. Surprisingly, however, in a quarter of species studied, parents ignore begging chicks. Furthermore, parents in some species even neglect smaller chicks that beg more, and preferentially feed the bigges...

journal_title：Nature communications

authors： Caro SM,Griffin AS,Hinde CA,West SA

更新日期：2016-03-29 00:00:00

abstract：:Roughly 40% of the Earth's total heat flow is powered by radioactive decays in the crust and mantle. Geo-neutrinos produced by these decays provide important clues about the origin, formation and thermal evolution of our planet, as well as the composition of its interior. Previous measurements of geo-neutrinos have al...

journal_title：Nature communications

authors： Leyton M,Dye S,Monroe J

更新日期：2017-07-10 00:00:00

abstract：:Melanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation. Here we show that ADAR1 silencing enhances melanoma cell in...

journal_title：Nature communications

authors： Nemlich Y,Baruch EN,Besser MJ,Shoshan E,Bar-Eli M,Anafi L,Barshack I,Schachter J,Ortenberg R,Markel G

更新日期：2018-05-31 00:00:00

abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...

journal_title：Nature communications

authors： Zhang F,Lemaur V,Choi W,Kafle P,Seki S,Cornil J,Beljonne D,Diao Y

更新日期：2019-09-16 00:00:00

abstract：:Intensive studies have recently been performed on graphene-based photodetectors, but most of them are based on field effect transistor structures containing mechanically exfoliated graphene, not suitable for practical large-scale device applications. Here we report high-efficient photodetector behaviours of chemical v...

journal_title：Nature communications

authors： Kim CO,Kim S,Shin DH,Kang SS,Kim JM,Jang CW,Joo SS,Lee JS,Kim JH,Choi SH,Hwang E

更新日期：2014-01-01 00:00:00

abstract：:Working memory is critical to cognition, decoupling behavior from the immediate world. Yet, it is imperfect; internal noise introduces errors into memory representations. Such errors have been shown to accumulate over time and increase with the number of items simultaneously held in working memory. Here, we show that ...

journal_title：Nature communications

authors： Panichello MF,DePasquale B,Pillow JW,Buschman TJ

更新日期：2019-07-29 00:00:00

abstract：:WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hi...

journal_title：Nature communications

authors： Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V

更新日期：2019-04-02 00:00:00

abstract：:The widespread use of fuel cells is currently limited by the lack of efficient and cost-effective catalysts for the oxygen reduction reaction. Iron-based non-precious metal catalysts exhibit promising activity and stability, as an alternative to state-of-the-art platinum catalysts. However, the identity of the active ...

journal_title：Nature communications

authors： Varnell JA,Tse EC,Schulz CE,Fister TT,Haasch RT,Timoshenko J,Frenkel AI,Gewirth AA

更新日期：2016-08-19 00:00:00

abstract：:Adolescence is a developmental period in which the mesolimbic dopaminergic "reward" circuitry of the brain, including the nucleus accumbens (NAc), undergoes significant plasticity. Dopamine D1 receptors (D1rs) in the NAc are critical for social behavior, but how these receptors are regulated during adolescence is not ...

journal_title：Nature communications

authors： Kopec AM,Smith CJ,Ayre NR,Sweat SC,Bilbo SD

更新日期：2018-09-25 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...

journal_title：Nature communications

authors： Arthur SE,Jiang A,Grande BM,Alcaide M,Cojocaru R,Rushton CK,Mottok A,Hilton LK,Lat PK,Zhao EY,Culibrk L,Ennishi D,Jessa S,Chong L,Thomas N,Pararajalingam P,Meissner B,Boyle M,Davidson J,Bushell KR,Lai D,Farinha

更新日期：2018-10-01 00:00:00

abstract：:Cascade reactions initiated by radical addition to alkynes are synthetically very attractive because they enable access to highly complex molecular skeletons in only few synthetic steps under usually mild conditions. Here we report a general radical cascade reaction of alkynes, N-fluoroarylsulfonimides and alcohols, e...

journal_title：Nature communications

authors： Zheng G,Li Y,Han J,Xiong T,Zhang Q

更新日期：2015-04-22 00:00:00

abstract：:Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymerize outward from adhesion sites to push membranes towards distant sit...

journal_title：Nature communications

authors： Garbett D,Bisaria A,Yang C,McCarthy DG,Hayer A,Moerner WE,Svitkina TM,Meyer T

更新日期：2020-09-23 00:00:00

abstract：:Fourier ring correlation (FRC) has recently gained popularity among fluorescence microscopists as a straightforward and objective method to measure the effective image resolution. While the knowledge of the numeric resolution value is helpful in e.g., interpreting imaging results, much more practical use can be made o...

journal_title：Nature communications

authors： Koho S,Tortarolo G,Castello M,Deguchi T,Diaspro A,Vicidomini G

更新日期：2019-07-15 00:00:00