Time-compressed preplay of anticipated events in human primary visual cortex.

abstract：:Targeted insertion of transgenes at pre-determined plant genomic safe harbors provides a desirable alternative to insertions at random sites achieved through conventional methods. Most existing cases of targeted gene insertion in plants have either relied on the presence of a selectable marker gene in the insertion ca...

journal_title：Nature communications

authors： Dong OX,Yu S,Jain R,Zhang N,Duong PQ,Butler C,Li Y,Lipzen A,Martin JA,Barry KW,Schmutz J,Tian L,Ronald PC

更新日期：2020-03-04 00:00:00

abstract：:Many-body entanglement is at the heart of the Kondo effect, which has its hallmark in quantum dots as a zero-bias conductance peak at low temperatures. It signals the emergence of a conducting singlet state formed by a localized dot degree of freedom and conduction electrons. Carbon nanotubes offer the possibility to ...

journal_title：Nature communications

authors： Niklas M,Smirnov S,Mantelli D,Margańska M,Nguyen NV,Wernsdorfer W,Cleuziou JP,Grifoni M

更新日期：2016-08-16 00:00:00

abstract：:Co-expression analysis is widely used to predict gene function and to identify functionally related gene sets. However, co-expression analysis using human cancer transcriptomic data is confounded by somatic copy number alterations (SCNA), which produce co-expression signatures based on physical proximity rather than b...

journal_title：Nature communications

authors： Cai L,Li Q,Du Y,Yun J,Xie Y,DeBerardinis RJ,Xiao G

更新日期：2017-12-19 00:00:00

abstract：:Processing of interleukin RNAs must be tightly controlled during the immune response. Here we report that a subnuclear body called the interleukin-6 and -10 splicing activating compartment (InSAC) is a nuclear site of cytokine RNA production and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) acts...

journal_title：Nature communications

authors： Lee S,Lee TA,Lee E,Kang S,Park A,Kim SW,Park HJ,Yoon JH,Ha SJ,Park T,Lee JS,Cheon JH,Park B

更新日期：2015-01-05 00:00:00

abstract：:While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using th...

journal_title：Nature communications

authors： Sornborger A,Li J,Timmons C,Lupu F,Eggenschwiler J,Takahama Y,Manley NR

更新日期：2017-05-30 00:00:00

abstract：:Generous behaviour is known to increase happiness, which could thereby motivate generosity. In this study, we use functional magnetic resonance imaging and a public pledge for future generosity to investigate the brain mechanisms that link generous behaviour with increases in happiness. Participants promised to spend ...

journal_title：Nature communications

authors： Park SQ,Kahnt T,Dogan A,Strang S,Fehr E,Tobler PN

更新日期：2017-07-11 00:00:00

abstract：:Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription...

journal_title：Nature communications

authors： Hasegawa S,Fukushima H,Hosoda H,Serita T,Ishikawa R,Rokukawa T,Kawahara-Miki R,Zhang Y,Ohta M,Okada S,Tanimizu T,Josselyn SA,Frankland PW,Kida S

更新日期：2019-12-18 00:00:00

abstract：:Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perform transcription or tran...

journal_title：Nature communications

authors： Ch R,Rey G,Ray S,Jha PK,Driscoll PC,Dos Santos MS,Malik DM,Lach R,Weljie AM,MacRae JI,Valekunja UK,Reddy AB

更新日期：2021-01-15 00:00:00

abstract：:As the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the f...

journal_title：Nature communications

authors： Davy M,Shi Z,Park J,Tian C,Genack AZ

更新日期：2015-04-20 00:00:00

abstract：:A magnetic impurity coupled to a superconductor gives rise to a Yu-Shiba-Rusinov (YSR) state inside the superconducting energy gap. With increasing exchange coupling the excitation energy of this state eventually crosses zero and the system switches to a YSR ground state with bound quasiparticles screening the impurit...

journal_title：Nature communications

authors： Grove-Rasmussen K,Steffensen G,Jellinggaard A,Madsen MH,Žitko R,Paaske J,Nygård J

更新日期：2018-06-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： López-Barneo J,Simon MC

更新日期：2020-02-25 00:00:00

abstract：:High-performance piezoelectrics are lead-based solid solutions that exhibit a so-called morphotropic phase boundary, which separates two competing phases as a function of chemical composition; as a consequence, an intermediate low-symmetry phase with a strong piezoelectric effect arises. In search for environmentally ...

journal_title：Nature communications

authors： Lummen TT,Gu Y,Wang J,Lei S,Xue F,Kumar A,Barnes AT,Barnes E,Denev S,Belianinov A,Holt M,Morozovska AN,Kalinin SV,Chen LQ,Gopalan V

更新日期：2014-01-01 00:00:00

abstract：:Ferroelectrics based on proton tautomerism are promising in low-field and above-room-temperature operations. Here seven organic ferroelectric crystals are examined to search for efficient switching of strong spontaneous polarization on proton tautomerism. Solution-grown crystals exhibit strong pinning of ferroelectric...

journal_title：Nature communications

authors： Horiuchi S,Kobayashi K,Kumai R,Ishibashi S

更新日期：2017-02-16 00:00:00

abstract：:Diversity-oriented synthesis (DOS) can provide a collection of diverse and complex drug-like small molecules, which is critical in the development of new chemical probes for biological research of undruggable targets. However, the design and synthesis of small-molecule libraries with improved biological relevance as w...

journal_title：Nature communications

authors： Kim J,Jung J,Koo J,Cho W,Lee WS,Kim C,Park W,Park SB

更新日期：2016-10-24 00:00:00

abstract：:The elastic-to-plastic transition during the deformation of a dislocation-free nanoscale volume is accompanied by displacement bursts associated with dislocation nucleation. The dislocations that nucleate during the so-called "pop-in" burst take the form of prismatic dislocation loops (PDLs) and exhibit characteristic...

journal_title：Nature communications

authors： Lee S,Vaid A,Im J,Kim B,Prakash A,Guénolé J,Kiener D,Bitzek E,Oh SH

更新日期：2020-05-12 00:00:00

abstract：:Long duration gamma-ray bursts (GRBs), the brightest events since the Big Bang itself, are believed to originate in an ultra-relativistic jet breaking out from a massive stellar envelope. Despite decades of study, there is still no consensus on their emission mechanism. One unresolved question is the origin of the tig...

journal_title：Nature communications

authors： Ito H,Matsumoto J,Nagataki S,Warren DC,Barkov MV,Yonetoku D

更新日期：2019-04-03 00:00:00

abstract：:Achieving and exceeding diversity of colloidal analogs of chemical elements and molecules as building blocks of matter has been the central goal and challenge of colloidal science ever since Einstein introduced the colloidal atom paradigm. Recent advances in colloids assembly have been achieved by exploiting the machi...

journal_title：Nature communications

authors： Senyuk B,Aplinc J,Ravnik M,Smalyukh II

更新日期：2019-04-23 00:00:00

abstract：:The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and genetically targeted approaches we have confirmed an indispensable role for vasoactive intestinal polypeptide-expressing SCN (SCNVIP) neurons, i...

journal_title：Nature communications

authors： Todd WD,Venner A,Anaclet C,Broadhurst RY,De Luca R,Bandaru SS,Issokson L,Hablitz LM,Cravetchi O,Arrigoni E,Campbell JN,Allen CN,Olson DP,Fuller PM

更新日期：2020-09-02 00:00:00

abstract：:Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...

journal_title：Nature communications

authors： Du Y,Ge Y,Ren Y,Fan X,Pan K,Lin L,Wu X,Min Y,Meyerson LA,Heino M,Chang SX,Liu X,Mao F,Yang G,Peng C,Qu Z,Chang J,Didham RK

更新日期：2018-10-08 00:00:00

abstract：:Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase loading o...

journal_title：Nature communications

authors： Qi R,Wang Y,Bruno PM,Xiao H,Yu Y,Li T,Lauffer S,Wei W,Chen Q,Kang X,Song H,Yang X,Huang X,Detappe A,Matulonis U,Pepin D,Hemann MT,Birrer MJ,Ghoroghchian PP

更新日期：2017-12-18 00:00:00

abstract：:Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylatio...

journal_title：Nature communications

authors： Zhou Y,Yamada N,Tanaka T,Hori T,Yokoyama S,Hayakawa Y,Yano S,Fukuoka J,Koizumi K,Saiki I,Sakurai H

更新日期：2015-07-09 00:00:00

abstract：:Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling proteins, also known as clients. Hsp90 ATPase activity is essential for its chaperone function and it is regulated by co-chaperones. Here we show that the tumour sup...

journal_title：Nature communications

authors： Woodford MR,Dunn DM,Blanden AR,Capriotti D,Loiselle D,Prodromou C,Panaretou B,Hughes PF,Smith A,Ackerman W,Haystead TA,Loh SN,Bourboulia D,Schmidt LS,Marston Linehan W,Bratslavsky G,Mollapour M

更新日期：2016-06-29 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:Monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as protein tags and components of biosensors for deep-tissue imaging and multicolour microscopy. We report three bright and spectrally distinct monomeric NIR FPs, termed miRFPs, engineered from bacterial phytochrome, which can be used as easil...

journal_title：Nature communications

authors： Shcherbakova DM,Baloban M,Emelyanov AV,Brenowitz M,Guo P,Verkhusha VV

更新日期：2016-08-19 00:00:00

abstract：:The unusual electronic properties of diamondoids, the nanoscale relatives of diamond, make them attractive for applications ranging from drug delivery to field emission displays. Identifying the fundamental origin of these properties has proven highly challenging, with even the most advanced quantum many-body calculat...

journal_title：Nature communications

authors： Patrick CE,Giustino F

更新日期：2013-01-01 00:00:00

abstract：:Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating t...

journal_title：Nature communications

authors： Akiyama M,Ishigaki K,Sakaue S,Momozawa Y,Horikoshi M,Hirata M,Matsuda K,Ikegawa S,Takahashi A,Kanai M,Suzuki S,Matsui D,Naito M,Yamaji T,Iwasaki M,Sawada N,Tanno K,Sasaki M,Hozawa A,Minegishi N,Wakai K,Tsugane S

更新日期：2019-09-27 00:00:00

abstract：:Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ(18)O for Last Glacial Maximum and deglacial corals...

journal_title：Nature communications

authors： Felis T,McGregor HV,Linsley BK,Tudhope AW,Gagan MK,Suzuki A,Inoue M,Thomas AL,Esat TM,Thompson WG,Tiwari M,Potts DC,Mudelsee M,Yokoyama Y,Webster JM

更新日期：2014-06-17 00:00:00

abstract：:During centriole duplication, a single daughter centriole is formed next to the mother centriole. The molecular mechanism that determines a single duplication site remains a long-standing question. Here, we show that intrinsic self-organization of Plk4 is implicated in symmetry breaking in the process of centriole dup...

journal_title：Nature communications

authors： Yamamoto S,Kitagawa D

更新日期：2019-04-18 00:00:00

abstract：:Surface-supported isolated atoms in single-atom catalysts (SACs) are usually stabilized by diverse defects. The fabrication of high-metal-loading and thermally stable SACs remains a formidable challenge due to the difficulty of creating high densities of underpinning stable defects. Here we report that isolated Pt ato...

journal_title：Nature communications

authors： Lang R,Xi W,Liu JC,Cui YT,Li T,Lee AF,Chen F,Chen Y,Li L,Li L,Lin J,Miao S,Liu X,Wang AQ,Wang X,Luo J,Qiao B,Li J,Zhang T

更新日期：2019-01-16 00:00:00

abstract：:Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient-specific screen leading to the identification of Otx2 and c-MYC as strong Group 3 MB inducers. We validated our findings in human cerebellar organoids...

journal_title：Nature communications

authors： Ballabio C,Anderle M,Gianesello M,Lago C,Miele E,Cardano M,Aiello G,Piazza S,Caron D,Gianno F,Ciolfi A,Pedace L,Mastronuzzi A,Tartaglia M,Locatelli F,Ferretti E,Giangaspero F,Tiberi L

更新日期：2020-01-29 00:00:00