Non defect-stabilized thermally stable single-atom catalyst.

abstract：:When pressure is applied, the molecules inside a crystal undergo significant changes of their stereoelectronic properties. The most interesting are those enhancing the reactivity of systems that would be otherwise rather inert at ambient conditions. Before a reaction can occur, however, a molecule must be activated, w...

journal_title：Nature communications

authors： Casati N,Kleppe A,Jephcoat AP,Macchi P

更新日期：2016-03-16 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00

abstract：:Causal reasoning can shed new light on the major challenges in machine learning for medical imaging: scarcity of high-quality annotated data and mismatch between the development dataset and the target environment. A causal perspective on these issues allows decisions about data collection, annotation, preprocessing, a...

journal_title：Nature communications

authors： Castro DC,Walker I,Glocker B

更新日期：2020-07-22 00:00:00

abstract：:Gastroenteritis accounts for nearly 500,000 deaths in children younger than 5 years annually. Although probiotics have been touted as having the potential to expedite diarrhea resolution, recent clinical trials question their effectiveness. A potential explanation is a shift in pathogens following the introduction of ...

journal_title：Nature communications

authors： Freedman SB,Xie J,Nettel-Aguirre A,Pang XL,Chui L,Williamson-Urquhart S,Schnadower D,Schuh S,Sherman PM,Lee BE,Gouin S,Farion KJ,Poonai N,Hurley KF,Qiu Y,Ghandi B,Lloyd C,Finkelstein Y,Pediatric Emergency Research Can

更新日期：2020-05-21 00:00:00

abstract：:Conventional lithium-ion batteries embrace graphite anodes which operate at potential as low as metallic lithium, subjected to poor rate capability and safety issues. Among possible alternatives, oxides based on titanium redox couple, such as spinel Li4Ti5O12, have received renewed attention. Here we further expand th...

journal_title：Nature communications

authors： Zhang L,Zhang X,Tian G,Zhang Q,Knapp M,Ehrenberg H,Chen G,Shen Z,Yang G,Gu L,Du F

更新日期：2020-07-13 00:00:00

abstract：:Ensuring that protected areas (PAs) maintain the biodiversity within their boundaries is fundamental in achieving global conservation goals. Despite this objective, wildlife abundance changes in PAs are patchily documented and poorly understood. Here, we use linear mixed effect models to explore correlates of populati...

journal_title：Nature communications

authors： Barnes MD,Craigie ID,Harrison LB,Geldmann J,Collen B,Whitmee S,Balmford A,Burgess ND,Brooks T,Hockings M,Woodley S

更新日期：2016-09-01 00:00:00

abstract：:Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find that intratumoral therapy with Newcastle disease virus (NDV), in add...

journal_title：Nature communications

authors： Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

更新日期：2017-02-13 00:00:00

abstract：:Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social and non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances in social functioning. Here we studied the behavior of patients with focal lesions to either BG or OFC in a...

journal_title：Nature communications

authors： Zhu L,Jiang Y,Scabini D,Knight RT,Hsu M

更新日期：2019-02-18 00:00:00

abstract：:The need for active and stable oxidation catalysts is driven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and energy sustainability. Traditional approaches focus on oxygen-activating oxides as support which provides the oxygen activation at the catalyst-support peripheral i...

journal_title：Nature communications

authors： Shan S,Li J,Maswadeh Y,O'Brien C,Kareem H,Tran DT,Lee IC,Wu ZP,Wang S,Yan S,Cronk H,Mott D,Yang L,Luo J,Petkov V,Zhong CJ

更新日期：2020-08-21 00:00:00

abstract：:Standard units of measurement are required for the quantitative description of nature; however, few standard units have been established for genomics to date. Here, we have developed a synthetic DNA ladder that defines a quantitative standard unit that can measure DNA sequence abundance within a next-generation sequen...

journal_title：Nature communications

authors： Reis ALM,Deveson IW,Wong T,Madala BS,Barker C,Blackburn J,Marcellin E,Mercer TR

更新日期：2020-07-17 00:00:00

abstract：:In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost...

journal_title：Nature communications

authors： Chelo IM,Nédli J,Gordo I,Teotónio H

更新日期：2013-01-01 00:00:00

abstract：:Despite the growing evidence for the regulated spindle orientation in mammals, a systematic approach for identifying the responsible genes in mammalian cells has not been established. Here we perform a kinase-targeting RNAi screen in HeLa cells and identify ABL1 as a novel regulator of spindle orientation. Knockdown o...

journal_title：Nature communications

authors： Matsumura S,Hamasaki M,Yamamoto T,Ebisuya M,Sato M,Nishida E,Toyoshima F

更新日期：2012-01-17 00:00:00

abstract：:Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from ...

journal_title：Nature communications

authors： Kuchenbaecker K,Telkar N,Reiker T,Walters RG,Lin K,Eriksson A,Gurdasani D,Gilly A,Southam L,Tsafantakis E,Karaleftheri M,Seeley J,Kamali A,Asiki G,Millwood IY,Holmes M,Du H,Guo Y,Kumari M,Dedoussis G,Li L,Chen Z

更新日期：2019-09-24 00:00:00

abstract：:Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...

journal_title：Nature communications

authors： Su BH,Tseng YL,Shieh GS,Chen YC,Shiang YC,Wu P,Li KJ,Yen TH,Shiau AL,Wu CL

更新日期：2013-01-01 00:00:00

abstract：:Chromatin remodeling is of crucial importance during brain development. Pathogenic alterations of several chromatin remodeling ATPases have been implicated in neurodevelopmental disorders. We describe an index case with a de novo missense mutation in CHD3, identified during whole genome sequencing of a cohort of child...

journal_title：Nature communications

authors： Snijders Blok L,Rousseau J,Twist J,Ehresmann S,Takaku M,Venselaar H,Rodan LH,Nowak CB,Douglas J,Swoboda KJ,Steeves MA,Sahai I,Stumpel CTRM,Stegmann APA,Wheeler P,Willing M,Fiala E,Kochhar A,Gibson WT,Cohen ASA,Agb

更新日期：2018-11-05 00:00:00

abstract：:Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter hypermethylation in 237 triple-negative breast cancers (TNBCs) from a population-based study using rep...

journal_title：Nature communications

authors： Glodzik D,Bosch A,Hartman J,Aine M,Vallon-Christersson J,Reuterswärd C,Karlsson A,Mitra S,Niméus E,Holm K,Häkkinen J,Hegardt C,Saal LH,Larsson C,Malmberg M,Rydén L,Ehinger A,Loman N,Kvist A,Ehrencrona H,Nik-Zainal

更新日期：2020-07-27 00:00:00

abstract：:The vertebrate mineralized skeleton is known to have first emerged as an exoskeleton that extensively covered the fossil jawless fish. The evolutionary origin of this exoskeleton has long been attributed to the emergence of the neural crest, but experimental evaluation for this is still poor. Here we determine the emb...

journal_title：Nature communications

authors： Shimada A,Kawanishi T,Kaneko T,Yoshihara H,Yano T,Inohaya K,Kinoshita M,Kamei Y,Tamura K,Takeda H

更新日期：2013-01-01 00:00:00

abstract：:Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence f...

journal_title：Nature communications

authors： Bénard A,Klimm K,Woodland AB,Arculus RJ,Wilke M,Botcharnikov RE,Shimizu N,Nebel O,Rivard C,Ionov DA

更新日期：2018-08-29 00:00:00

abstract：:Molecular shape recognition for larger guest molecules (typically over 1 nm) is a difficult task because it requires cooperativity within a wide three-dimensional nanospace coincidentally probing every molecular aspect (size, outline shape, flexibility and specific groups). Although the intelligent functions of protei...

journal_title：Nature communications

authors： Imaoka T,Kawana Y,Kurokawa T,Yamamoto K

更新日期：2013-01-01 00:00:00

abstract：:Many microorganisms, with phytoplankton and zooplankton as prominent examples, display phototactic behaviour, that is, the ability to perform directed motion within a light gradient. Here we experimentally demonstrate that sensing of light gradients can also be achieved in a system of synthetic photo-activated micropa...

journal_title：Nature communications

authors： Lozano C,Ten Hagen B,Löwen H,Bechinger C

更新日期：2016-09-30 00:00:00

abstract：:Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Berry MH,Holt A,Levitz J,Broichhagen J,Gaub BM,Visel M,Stanley C,Aghi K,Kim YJ,Cao K,Kramer RH,Trauner D,Flannery J,Isacoff EY

更新日期：2018-03-13 00:00:00

abstract：:Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut mic...

journal_title：Nature communications

authors： Vojinovic D,Radjabzadeh D,Kurilshikov A,Amin N,Wijmenga C,Franke L,Ikram MA,Uitterlinden AG,Zhernakova A,Fu J,Kraaij R,van Duijn CM

更新日期：2019-12-20 00:00:00

abstract：:Familial hemiplegic migraine is an episodic neurological disorder characterized by transient sensory and motor symptoms and signs. Mutations of the ion pump α2-Na/K ATPase cause familial hemiplegic migraine, but the mechanisms by which α2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely underst...

journal_title：Nature communications

authors： Smith SE,Chen X,Brier LM,Bumstead JR,Rensing NR,Ringel AE,Shin H,Oldenborg A,Crowley JR,Bice AR,Dikranian K,Ippolito JE,Haigis MC,Papouin T,Zhao G,Wong M,Culver JP,Bonni A

更新日期：2020-12-02 00:00:00

abstract：:Structural rearrangements govern the various properties of disordered systems and visualization of these dynamical processes can provide critical information on structural deformation and phase transformation of the systems. However, direct imaging of individual atoms or molecules in a disordered state is quite challe...

journal_title：Nature communications

authors： Choe J,Lee Y,Park J,Kim Y,Kim CU,Kim K

更新日期：2019-09-27 00:00:00

abstract：:Ca2+ coordinates diverse cellular processes, yet how function-specific signals arise is enigmatic. We describe a cell-wide network of distinct cytoplasmic nanocourses with the nucleus at its centre, demarcated by sarcoplasmic reticulum (SR) junctions (≤400 nm across) that restrict Ca2+ diffusion and by nanocourse-spec...

journal_title：Nature communications

authors： Duan J,Navarro-Dorado J,Clark JH,Kinnear NP,Meinke P,Schirmer EC,Evans AM

更新日期：2019-05-24 00:00:00

abstract：:Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited due to the paucity of comprehensive mutation data on this rare tumor type. To better understand the genomic landscape of mucosal melanoma, here we describe whole genome sequencing analysis of 67 tumors and validation of driver gene mutatio...

journal_title：Nature communications

authors： Newell F,Kong Y,Wilmott JS,Johansson PA,Ferguson PM,Cui C,Li Z,Kazakoff SH,Burke H,Dodds TJ,Patch AM,Nones K,Tembe V,Shang P,van der Weyden L,Wong K,Holmes O,Lo S,Leonard C,Wood S,Xu Q,Rawson RV,Mukhopadhyay P

更新日期：2019-07-18 00:00:00

abstract：:Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well...

journal_title：Nature communications

authors： Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra N

更新日期：2017-01-27 00:00:00

abstract：:The ontogeny of haematopoietic niches in vertebrates is essentially unknown. Here we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zebrafish development, derive from the caudal somites through an epithelial-m...

journal_title：Nature communications

authors： Murayama E,Sarris M,Redd M,Le Guyader D,Vivier C,Horsley W,Trede N,Herbomel P

更新日期：2015-09-28 00:00:00

abstract：:This paper considers options for a future Indian power economy in which renewables, wind and solar, could meet 80% of anticipated 2040 power demand supplanting the country's current reliance on coal. Using a cost optimization model, here we show that renewables could provide a source of power cheaper or at least compe...

journal_title：Nature communications

authors： Lu T,Sherman P,Chen X,Chen S,Lu X,McElroy M

更新日期：2020-09-21 00:00:00

abstract：:Vibrio cholerae, responsible for acute gastroenteritis secretes a large multifunctional-autoprocessing repeat-in-toxin (MARTX) toxin linked to evasion of host immune system, facilitating colonization of small intestine. Unlike other effector domains of the multifunctional toxin that target cytoskeleton, the function o...

journal_title：Nature communications

authors： Agarwal S,Kim H,Chan RB,Agarwal S,Williamson R,Cho W,Paolo GD,Satchell KJ

更新日期：2015-10-26 00:00:00