Abstract：
:Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well-established function as tumour suppressor. Here, we provide genetic evidence of an unexpected tumour-promoting effect of NKG2D in a model of inflammation-driven liver cancer. Compared to NKG2D-deficient mice, NKG2D-sufficient mice display accelerated tumour growth associated with, an increased recruitment of memory CD8+T cells to the liver and exacerbated pro-inflammatory milieu. In addition, we show that NKG2D contributes to liver damage and consequent hepatocyte proliferation known to favour tumorigenesis. Thus, the NKG2D/NKG2D-ligand pathway provides an additional mechanism linking chronic inflammation to tumour development in hepatocellular carcinoma. Our findings expose the need to selectively target the types of cancer that could benefit from NKG2D-based immunotherapy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra Ndoi
10.1038/ncomms13930subject
Has Abstractpub_date
2017-01-27 00:00:00pages
13930issn
2041-1723pii
ncomms13930journal_volume
8pub_type
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