Abstract:
:The ontogeny of haematopoietic niches in vertebrates is essentially unknown. Here we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zebrafish development, derive from the caudal somites through an epithelial-mesenchymal transition (EMT). The resulting stromal cell progenitors accompany the formation of the caudal vein sinusoids, the other main component of the CHT niche, and mature into reticular cells lining and interconnecting sinusoids. We characterize a zebrafish mutant defective in definitive haematopoiesis due to a deficiency in the nascent polypeptide-associated complex alpha subunit (NACA). We demonstrate that the defect resides not in HSPCs but in the CHT niche. NACA-deficient stromal cell progenitors initially develop normally together with the sinusoids, and HSPCs home to the resulting niche, but stromal cell maturation is compromised, leading to a niche that is unable to support HSPC maintenance, expansion and differentiation.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Murayama E,Sarris M,Redd M,Le Guyader D,Vivier C,Horsley W,Trede N,Herbomel Pdoi
10.1038/ncomms9375subject
Has Abstractpub_date
2015-09-28 00:00:00pages
8375issn
2041-1723pii
ncomms9375journal_volume
6pub_type
杂志文章abstract::Woody (lignocellulosic) plant biomass is an abundant renewable feedstock, rich in polysaccharides that are bound into an insoluble fiber composite with lignin. Marine crustacean woodborers of the genus Limnoria are among the few animals that can survive on a diet of this recalcitrant material without relying on gut re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07575-2
更新日期:2018-12-03 00:00:00
abstract::Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12667
更新日期:2016-10-11 00:00:00
abstract::Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar pla...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2370
更新日期:2013-01-01 00:00:00
abstract::Electron-rich dienes have revolutionized the synthesis of complex compounds since the discovery of the legendary Diels-Alder cycloaddition reaction. This highly efficient bond-forming process has served as a fundamental strategy to assemble many structurally formidable molecules. Amino silyloxy butadienes are arguably...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7913
更新日期:2015-04-21 00:00:00
abstract::Zinc-finger nuclease, transcription activator-like effector nuclease and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are becoming major tools for genome editing. Importantly, knock-in in several non-rodent species has been finally achieved thanks to these custo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10548
更新日期:2016-01-28 00:00:00
abstract::Broomcorn millet (Panicum miliaceum L.) has strong tolerance to abiotic stresses, and is probably one of the oldest crops, with its earliest cultivation that dated back to ca. ~10,000 years. We report here its genome assembly through a combination of PacBio sequencing, BioNano, and Hi-C (in vivo) mapping. The 18 super...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07876-6
更新日期:2019-01-25 00:00:00
abstract::Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic dynein. Here using in utero electroporation of NDE1 short hairpin RN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12551
更新日期:2016-08-24 00:00:00
abstract::Research on surface plasmon resonance coupling of metallic nanostructures is an important area in the field of plasmonics because distinctive collective optical properties can be realized that are different from the individual constituents. Here we report the localized surface plasmon resonance of hybrid metal-organic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03453-z
更新日期:2018-03-08 00:00:00
abstract::China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric Heating Policy (EHP) has contributed to significant improvements in air quality, benefiting hundreds of millions of people. This shift, however, has resulted in a sharp increas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19854-y
更新日期:2020-11-27 00:00:00
abstract::Optical phase change materials (O-PCMs), a unique group of materials featuring exceptional optical property contrast upon a solid-state phase transition, have found widespread adoption in photonic applications such as switches, routers and reconfigurable meta-optics. Current O-PCMs, such as Ge-Sb-Te (GST), exhibit lar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12196-4
更新日期:2019-09-30 00:00:00
abstract::Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we repo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11210
更新日期:2016-04-04 00:00:00
abstract::Interferon gamma (IFNγ)-producing CD8(+) T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8(+) T cells to generate Tc1 cells, not only increases IFNγ production but also boosts the generation of reactive oxygen species (ROS) and augments expression of C...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9819
更新日期:2015-11-09 00:00:00
abstract::The complexity embedded in condensed matter fertilizes the discovery of new states of matter, enriched by ingredients like frustration. Illustrating examples in magnetic systems are Kitaev spin liquids, skyrmions phases, or spin ices. These unconventional ground states support exotic excitations, for example the magne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00277-1
更新日期:2017-08-08 00:00:00
abstract::Solid substrates often induce non-uniform strain and doping in graphene monolayer, therefore altering the intrinsic properties of graphene, reducing its charge carrier mobilities and, consequently, the overall electrical performance. Here, we exploit confocal Raman spectroscopy to study graphene directly free-floating...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14637-x
更新日期:2020-02-14 00:00:00
abstract::The photon-like behavior of electrons in graphene causes unusual confinement properties that depend strongly on the geometry and strength of the surrounding potential. We report bottom-up synthesis of atomically-precise one-dimensional (1D) arrays of point charges on graphene that allow exploration of a new type of su...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08371-2
更新日期:2019-01-29 00:00:00
abstract::Droplet-based microfluidic devices hold immense potential in becoming inexpensive alternatives to existing screening platforms across life science applications, such as enzyme discovery and early cancer detection. However, the lack of a predictive understanding of droplet generation makes engineering a droplet-based p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20284-z
更新日期:2021-01-04 00:00:00
abstract::Soil bacterial diversity varies across biomes with potential impacts on soil ecological functioning. Here, we incorporate key factors that affect soil bacterial abundance and diversity across spatial scales into a mechanistic modeling framework considering soil type, carbon inputs and climate towards predicting soil b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13966-w
更新日期:2020-01-08 00:00:00
abstract::Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03874-w
更新日期:2018-05-01 00:00:00
abstract::The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit criti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15908-3
更新日期:2020-05-01 00:00:00
abstract::Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally employing proposed climate geoengineering technologies, either through atmospheric carbon dioxide re...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-018-05938-3
更新日期:2018-09-13 00:00:00
abstract::Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation effici...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05232-2
更新日期:2018-07-13 00:00:00
abstract::All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behaviora...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03262-4
更新日期:2018-02-26 00:00:00
abstract::Understanding the response of granular matter to intrusion of solid objects is key to modelling many aspects of behaviour of granular matter, including plastic flow. Here we report a general model for such a quasistatic process. Using a range of experiments, we first show that the relation between the penetration dept...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03344-3
更新日期:2018-03-16 00:00:00
abstract::Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19880-w
更新日期:2020-12-01 00:00:00
abstract::Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8940
更新日期:2015-08-13 00:00:00
abstract::HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03565-6
更新日期:2018-03-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13862-3
更新日期:2020-01-14 00:00:00
abstract::R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-lo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06677-1
更新日期:2018-10-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13138-w
更新日期:2019-11-22 00:00:00
abstract::Cyanobacteria are model organisms for photosynthesis and are attractive for biotechnology applications. To aid investigation of genotype-phenotype relationships in cyanobacteria, we develop an inducible CRISPRi gene repression library in Synechocystis sp. PCC 6803, where we aim to target all genes for repression. We t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15491-7
更新日期:2020-04-03 00:00:00