NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine.

abstract：:Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...

journal_title：Nature communications

authors： Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW

更新日期：2021-01-21 00:00:00

abstract：:It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction...

journal_title：Nature communications

authors： Robinson JE,Paluch J,Dickman DK,Joiner WJ

更新日期：2016-01-27 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and...

journal_title：Nature communications

authors： Biancur DE,Paulo JA,Małachowska B,Quiles Del Rey M,Sousa CM,Wang X,Sohn ASW,Chu GC,Gygi SP,Harper JW,Fendler W,Mancias JD,Kimmelman AC

更新日期：2017-07-03 00:00:00

abstract：:Aerosol-cloud interactions constitute the largest source of uncertainty in global radiative forcing estimates, hampering our understanding of climate evolution. Recent empirical evidence suggests surface tension depression by organic aerosol to significantly influence the formation of cloud droplets, and hence cloud o...

journal_title：Nature communications

authors： Lowe SJ,Partridge DG,Davies JF,Wilson KR,Topping D,Riipinen I

更新日期：2019-11-18 00:00:00

abstract：:Considering the synthetic value of introducing active alcoholic hydroxyl group, developing C-H functionalization of alcohols is of significance. Herein, we present a photochemical method that under visible light irradiation, selectfluor can effectively promote the oxidative cross-coupling between alcohols and heteroar...

journal_title：Nature communications

authors： Niu L,Liu J,Liang XA,Wang S,Lei A

更新日期：2019-01-28 00:00:00

abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

journal_title：Nature communications

authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

更新日期：2018-09-13 00:00:00

abstract：:The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs...

journal_title：Nature communications

authors： Miyawaki S,Kawamura Y,Oiwa Y,Shimizu A,Hachiya T,Bono H,Koya I,Okada Y,Kimura T,Tsuchiya Y,Suzuki S,Onishi N,Kuzumaki N,Matsuzaki Y,Narita M,Ikeda E,Okanoya K,Seino K,Saya H,Okano H,Miura K

更新日期：2016-05-10 00:00:00

abstract：:Dense ceramic materials can form in nature under mild temperatures in water. By contrast, man-made ceramics often require sintering temperatures in excess of 1,400 °C for densification. Chemical strategies inspired by biomineralization processes have been demonstrated but remain limited to the fabrication of thin film...

journal_title：Nature communications

authors： Bouville F,Studart AR

更新日期：2017-03-06 00:00:00

abstract：:A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters macrophage cytokine...

journal_title：Nature communications

authors： Singh KS,Leu JI,Barnoud T,Vonteddu P,Gnanapradeepan K,Lin C,Liu Q,Barton JC,Kossenkov AV,George DL,Murphy ME,Dotiwala F

更新日期：2020-01-24 00:00:00

abstract：:Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto t...

journal_title：Nature communications

authors： Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD

更新日期：2018-09-07 00:00:00

abstract：:Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression-methylation quantitative trait loci (emQTL) analysis between DNA methylation and gene expression. On a w...

journal_title：Nature communications

authors： Fleischer T,Tekpli X,Mathelier A,Wang S,Nebdal D,Dhakal HP,Sahlberg KK,Schlichting E,Oslo Breast Cancer Research Consortium (OSBREAC).,Børresen-Dale AL,Borgen E,Naume B,Eskeland R,Frigessi A,Tost J,Hurtado A,Kristensen VN

更新日期：2017-11-09 00:00:00

abstract：:Nanoparticles attached just above a flat metallic surface can trap optical fields in the nanoscale gap. This enables local spectroscopy of a few molecules within each coupled plasmonic hotspot, with near thousand-fold enhancement of the incident fields. As a result of non-radiative relaxation pathways, the plasmons in...

journal_title：Nature communications

authors： de Nijs B,Benz F,Barrow SJ,Sigle DO,Chikkaraddy R,Palma A,Carnegie C,Kamp M,Sundararaman R,Narang P,Scherman OA,Baumberg JJ

更新日期：2017-10-20 00:00:00

abstract：:In the original version of this Article, the four structural depictions of orbital distributions were inadvertently omitted from Figure 5. This has now been corrected in both the HTML and PDF versions of the Article. ...

journal_title：Nature communications

authors： Zhao J,Peng Q,Wang Z,Xu W,Xiao H,Wu Q,Sun HL,Ma F,Zhao J,Sun CJ,Zhao J,Li J

更新日期：2019-06-21 00:00:00

abstract：:Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-di...

journal_title：Nature communications

authors： Sun Y,Ma K,Kao T,Spoth KA,Sai H,Zhang D,Kourkoutis LF,Elser V,Wiesner U

更新日期：2017-08-15 00:00:00

abstract：:Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional proteolytic mechanisms...

journal_title：Nature communications

authors： Kojima Y,Machida Y,Palani S,Caulfield TR,Radisky ES,Kaufmann SH,Machida YJ

更新日期：2020-03-12 00:00:00

abstract：:While main group elements have four valence orbitals accessible for bonding, quadruple bonding to main group elements is extremely rare. Here we report that main group element boron is able to form quadruple bonding interactions with iron in the BFe(CO)3- anion complex, which has been revealed by quantum chemical inve...

journal_title：Nature communications

authors： Chi C,Wang JQ,Hu HS,Zhang YY,Li WL,Meng L,Luo M,Zhou M,Li J

更新日期：2019-10-17 00:00:00

abstract：:Trace elements diffuse negligible distances through the pristine crystal lattice in minerals: this is a fundamental assumption when using them to decipher geological processes. For example, the reliable use of the mineral zircon (ZrSiO4) as a U-Th-Pb geochronometer and trace element monitor requires minimal radiogenic...

journal_title：Nature communications

authors： Piazolo S,La Fontaine A,Trimby P,Harley S,Yang L,Armstrong R,Cairney JM

更新日期：2016-02-12 00:00:00

abstract：:It is well known that both recipient cells and donor nuclei demonstrate a mitotic advantage as observed in the traditional reprogramming with somatic cell nuclear transfer (SCNT). However, it is not known whether a specific mitotic factor plays a critical role in reprogramming. Here we identify an isoform of human bro...

journal_title：Nature communications

authors： Shao Z,Zhang R,Khodadadi-Jamayran A,Chen B,Crowley MR,Festok MA,Crossman DK,Townes TM,Hu K

更新日期：2016-03-07 00:00:00

abstract：:The exploration of chemical space for new reactivity, reactions and molecules is limited by the need for separate work-up-separation steps searching for molecules rather than reactivity. Herein we present a system that can autonomously evaluate chemical reactivity within a network of 64 possible reaction combinations ...

journal_title：Nature communications

authors： Dragone V,Sans V,Henson AB,Granda JM,Cronin L

更新日期：2017-06-09 00:00:00

abstract：:The combined effects of anthropogenic and biological CO2 inputs may lead to more rapid acidification in coastal waters compared to the open ocean. It is less clear, however, how redox reactions would contribute to acidification. Here we report estuarine acidification dynamics based on oxygen, hydrogen sulfide (H2S), p...

journal_title：Nature communications

authors： Cai WJ,Huang WJ,Luther GW 3rd,Pierrot D,Li M,Testa J,Xue M,Joesoef A,Mann R,Brodeur J,Xu YY,Chen B,Hussain N,Waldbusser GG,Cornwell J,Kemp WM

更新日期：2017-08-28 00:00:00

abstract：:How the positional values along the proximo-distal axis (stylopod-zeugopod-autopod) of the limb are specified is intensely debated. Early work suggested that cells intrinsically change their proximo-distal positional values by measuring time. Recently, however, it is suggested that instructive extrinsic signals from t...

journal_title：Nature communications

authors： Saiz-Lopez P,Chinnaiya K,Campa VM,Delgado I,Ros MA,Towers M

更新日期：2015-09-18 00:00:00

abstract：:In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from National Institute of General Medical Sciences, National Institutes of Health grant R01GM124072. ...

journal_title：Nature communications

authors： Lorent JH,Diaz-Rohrer B,Lin X,Spring K,Gorfe AA,Levental KR,Levental I

更新日期：2018-05-01 00:00:00

abstract：:A key challenge in the field of molecular spintronics, and for the design of single-molecule magnet-based devices in particular, is the understanding and control of the molecular coupling at the electrode interfaces. It was demonstrated for the field of molecular electronics that the characterization of the molecule-m...

journal_title：Nature communications

authors： Schwöbel J,Fu Y,Brede J,Dilullo A,Hoffmann G,Klyatskaya S,Ruben M,Wiesendanger R

更新日期：2012-07-17 00:00:00

abstract：:The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. He...

journal_title：Nature communications

authors： Araiz C,Yan A,Bettedi L,Samuelson I,Virtue S,McGavigan AK,Dani C,Vidal-Puig A,Foukas LC

更新日期：2019-04-04 00:00:00

abstract：:New capabilities at X-ray free-electron laser facilities allow the generation of two-colour femtosecond X-ray pulses, opening the possibility of performing ultrafast studies of X-ray-induced phenomena. Particularly, the experimental realization of hetero-site-specific X-ray-pump/X-ray-probe spectroscopy is of special ...

journal_title：Nature communications

authors： Picón A,Lehmann CS,Bostedt C,Rudenko A,Marinelli A,Osipov T,Rolles D,Berrah N,Bomme C,Bucher M,Doumy G,Erk B,Ferguson KR,Gorkhover T,Ho PJ,Kanter EP,Krässig B,Krzywinski J,Lutman AA,March AM,Moonshiram D,Ray D,

更新日期：2016-05-23 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is insufficient to cause disease, suggests other co-factors are involved. Here we present epidemiolog...

journal_title：Nature communications

authors： Sallah N,Miley W,Labo N,Carstensen T,Fatumo S,Gurdasani D,Pollard MO,Dilthey AT,Mentzer AJ,Marshall V,Cornejo Castro EM,Pomilla C,Young EH,Asiki G,Hibberd ML,Sandhu M,Kellam P,Newton R,Whitby D,Barroso I

更新日期：2020-07-31 00:00:00

abstract：:In two-dimensional (2D) lattices, the electronic levels are unevenly spaced, and the density of states (DOS) displays a logarithmic divergence known as the Van Hove singularity (VHS). This is the case in particular for the layered cuprate superconductors. The scanning tunnelling microscope (STM) probes the DOS, and is...

journal_title：Nature communications

authors： Piriou A,Jenkins N,Berthod C,Maggio-Aprile I,Fischer O

更新日期：2011-01-01 00:00:00

abstract：:Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...

journal_title：Nature communications

authors： Qi H,Zhang H,Zhao Y,Chen C,Long JJ,Chung WK,Guan Y,Shen Y

更新日期：2021-01-21 00:00:00

abstract：:Plant phytochromes are thought to transduce light signals by mediating the degradation of phytochrome-interacting transcription factors (PIFs) through the N-terminal photosensory module, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not participate in signaling. Here we show tha...

journal_title：Nature communications

authors： Qiu Y,Pasoreck EK,Reddy AK,Nagatani A,Ma W,Chory J,Chen M

更新日期：2017-12-04 00:00:00

abstract：:Many low-thermal-conductivity (κL) crystals show intriguing temperature (T) dependence of κL: κL ∝ T-1 (crystal-like) at intermediate temperatures whereas weak T-dependence (glass-like) at high temperatures. It has been in debate whether thermal transport can still be described by phonons at the Ioffe-Regel limit. In ...

journal_title：Nature communications

authors： Luo Y,Yang X,Feng T,Wang J,Ruan X

更新日期：2020-05-22 00:00:00