Abstract:
:Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and that inhibition of downstream components of Gln metabolism leads to a decrease in tumour growth. Here we test whether recently developed inhibitors of glutaminase (GLS), which mediates an early step in Gln metabolism, represent a viable therapeutic strategy. We show that despite marked early effects on in vitro proliferation caused by GLS inhibition, pancreatic cancer cells have adaptive metabolic networks that sustain proliferation in vitro and in vivo. We use an integrated metabolomic and proteomic platform to understand this adaptive response and thereby design rational combinatorial approaches. We demonstrate that pancreatic cancer metabolism is adaptive and that targeting Gln metabolism in combination with these adaptive responses may yield clinical benefits for patients.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Biancur DE,Paulo JA,Małachowska B,Quiles Del Rey M,Sousa CM,Wang X,Sohn ASW,Chu GC,Gygi SP,Harper JW,Fendler W,Mancias JD,Kimmelman ACdoi
10.1038/ncomms15965subject
Has Abstractpub_date
2017-07-03 00:00:00pages
15965issn
2041-1723pii
ncomms15965journal_volume
8pub_type
杂志文章abstract::A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14416-8
更新日期:2020-02-04 00:00:00
abstract::The original version of this Article contained an error in the spelling of the author Jianyun Yan, which was incorrectly given as Jiangyun Yan. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-017-02617-7
更新日期:2018-01-12 00:00:00
abstract::Perovskite solar cells present one of the most prominent photovoltaic technologies, yet their stability, scalability, and engineering at the molecular level remain challenging. We demonstrate a concept of multifunctional molecular modulation of scalable and operationally stable perovskite solar cells that exhibit exce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06709-w
更新日期:2018-10-26 00:00:00
abstract::One of the main reasons why nonlinear-optical signal processing (regeneration, logic, etc.) has not yet become a practical alternative to electronic processing is that the all-optical elements with nonlinear input-output relationship have remained inherently single-channel devices (just like their electronic counterpa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00874-0
更新日期:2017-10-12 00:00:00
abstract::Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20831-8
更新日期:2021-01-29 00:00:00
abstract::The magnetic excitations in the cuprate superconductors might be essential for an understanding of high-temperature superconductivity. In these cuprate superconductors the magnetic excitation spectrum resembles an hour-glass and certain resonant magnetic excitations within are believed to be connected to the pairing m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6731
更新日期:2014-12-23 00:00:00
abstract::The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11617
更新日期:2016-05-25 00:00:00
abstract::Signaling molecules that regulate neurodevelopmental processes in the early postnatal subventricular zone (SVZ) are critical for proper brain development yet remain poorly characterized. Here, we report that Endothelin-1 (ET-1), a molecular component of the postnatal SVZ, promotes radial glial cell maintenance and pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16028-8
更新日期:2020-05-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17055-1
更新日期:2020-07-06 00:00:00
abstract::The rate of interictal high frequency oscillations (HFOs) is a promising biomarker of the seizure onset zone, though little is known about its consistency over hours to days. Here we test whether the highest HFO-rate channels are consistent across different 10-min segments of EEG during sleep. An automated HFO detecto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04549-2
更新日期:2018-06-01 00:00:00
abstract::The discovery of quantum spin-Hall (QSH) insulators has brought topology to the forefront of condensed matter physics. While a QSH state from spin-orbit coupling can be fully understood in terms of band theory, fascinating many-body effects are expected if it instead results from spontaneous symmetry breaking. Here, w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10372-0
更新日期:2019-06-14 00:00:00
abstract::Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstruction of Ebp1 boun...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14603-7
更新日期:2020-02-07 00:00:00
abstract::The host-guest recognition between two macrocycles to form hierarchical non-intertwined ring-in-ring assemblies remains an interesting and challenging target in noncovalent synthesis. Herein, we report the design and characterization of a box-in-box assembly on the basis of host-guest radical-pairing interactions betw...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07673-1
更新日期:2018-12-10 00:00:00
abstract::Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19684-y
更新日期:2020-11-17 00:00:00
abstract::Elucidating the factors governing the functional compatibility of horizontally transferred genes is important to understand bacterial evolution, including the emergence and spread of antibiotic resistance, and to successfully engineer biological systems. In silico efforts and work using single-gene libraries have sugg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02944-3
更新日期:2018-02-06 00:00:00
abstract::The dynamic incorporation of histone variants influences chromatin structure and many biological processes. In Arabidopsis, the canonical variant H3.1 differs from H3.3 in four residues, one of which (H3.1Phe41) is unique and conserved in plants. However, its evolutionary significance remains unclear. Here, we show th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02976-9
更新日期:2018-02-12 00:00:00
abstract::Graphyne allotropes of carbon are fascinating materials, and their electronic properties are predicted to rival those of the "wonder material" graphene. One allotrope of graphyne, having rectangular symmetry rather than hexagonal, stands out as particularly attractive, namely 6,6,12-graphyne. It is currently an insurm...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11700-0
更新日期:2019-08-16 00:00:00
abstract::Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20-30 s. Here we report genome-wide binding for ~80% of all predicted MTB transcription factors (TFs), and assayed global expression following induction of each TF. The MTB DNA-binding network consists of ~16,000 binding events from 154...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6829
更新日期:2015-01-12 00:00:00
abstract::Carbon-based three-dimensional aerographite networks, built from interconnected hollow tubular tetrapods of multilayer graphene, are ultra-lightweight materials recently discovered and ideal for advanced multifunctional applications. In order to predict the bulk mechanical behaviour of networks it is very important to...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14982
更新日期:2017-04-12 00:00:00
abstract::Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different intensity, exhibits enhanced dissymmetry in its interaction with chiral molecules, and has the potential for ultrasensitive detection and characterization ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07533-y
更新日期:2018-11-30 00:00:00
abstract::Conventional interferometers usually utilize beam splitters for wave splitting and recombination. These interferometers are widely used for precision measurement. Their sensitivity for phase measurement is limited by the shot noise, which can be suppressed with squeezed states of light. Here we study a new type of int...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4049
更新日期:2014-01-01 00:00:00
abstract::Thin-film transistor (TFT)-driven full-color organic light-emitting diodes (OLEDs) with vertically stacked structures are developed herein using photolithography processes, which allow for high-resolution displays of over 2,000 pixels per inch. Vertical stacking of OLEDs by the photolithography process is technically ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16551-8
更新日期:2020-06-01 00:00:00
abstract::DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17531-8
更新日期:2020-07-24 00:00:00
abstract::Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica. Classical monocytes as well as testosterone are identified to have important functions for the development of hepatic amebiasis in mice, but a link between testosterone and monocy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17260-y
更新日期:2020-07-10 00:00:00
abstract::Wnt signaling is critical for directing epithelial gland development within the uterine lining to ensure successful gestation in adults. Wnt-dependent, Lgr5-expressing stem/progenitor cells are essential for the development of glandular epithelia in the intestine and stomach, but their existence in the developing repr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13363-3
更新日期:2019-11-26 00:00:00
abstract::Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4309
更新日期:2014-01-01 00:00:00
abstract::The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04545-6
更新日期:2018-05-21 00:00:00
abstract::Glacier retreat is a worldwide phenomenon with important consequences for the hydrological cycle and downstream ecosystem structure and functioning. To determine the effects of glacier retreat on aquatic communities, we conducted a 4-year flow manipulation in a tropical glacier-fed stream. Compared with an adjacent re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12025
更新日期:2016-06-24 00:00:00
abstract::Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temperature also exhibit emergent physical phenomena and are of great promise for optoelectronic applications. Here, we demonstrate that nanostructured, multilayer transition metal dichalcogenides (TMDCs) by themselves pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17313-2
更新日期:2020-07-15 00:00:00
abstract::Damage to the genome is implicated in the progression of cancer and stress-induced diseases. DNA lesions exist in low levels, and cannot be amplified by standard PCR because they are frequently strong blocks to polymerases. Here, we describe a method for PCR amplification of lesion-containing DNA in which the site and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9807
更新日期:2015-11-06 00:00:00