Identification of DNA lesions using a third base pair for amplification and nanopore sequencing.

abstract：:Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Ne...

journal_title：Nature communications

authors： Fukushima T,Yoshihara H,Furuta H,Kamei H,Hakuno F,Luan J,Duan C,Saeki Y,Tanaka K,Iemura S,Natsume T,Chida K,Nakatsu Y,Kamata H,Asano T,Takahashi S

更新日期：2015-04-16 00:00:00

abstract：:Semiconductur nano- and micropillars represent a promising platform for hybrid nanodevices. Their ability to couple to a broad variety of nanomechanical, acoustic, charge, spin, excitonic, polaritonic, or electromagnetic excitations is utilized in fields as diverse as force sensing or optoelectronics. In order to full...

journal_title：Nature communications

authors： Doster J,Hoenl S,Lorenz H,Paulitschke P,Weig EM

更新日期：2019-11-20 00:00:00

abstract：:Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis arises from the benefit of tuning phenoty...

journal_title：Nature communications

authors： Nghe P,Kogenaru M,Tans SJ

更新日期：2018-04-13 00:00:00

abstract：:Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ioni...

journal_title：Nature communications

authors： Corde S,Adli E,Allen JM,An W,Clarke CI,Clausse B,Clayton CE,Delahaye JP,Frederico J,Gessner S,Green SZ,Hogan MJ,Joshi C,Litos M,Lu W,Marsh KA,Mori WB,Vafaei-Najafabadi N,Walz D,Yakimenko V

更新日期：2016-06-17 00:00:00

abstract：:The diversity in our genome is crucial to understanding the demographic history of worldwide populations. However, we have yet to know whether subtle genetic differences within a population can be disentangled, or whether they have an impact on complex traits. Here we apply dimensionality reduction methods (PCA, t-SNE...

journal_title：Nature communications

authors： Sakaue S,Hirata J,Kanai M,Suzuki K,Akiyama M,Lai Too C,Arayssi T,Hammoudeh M,Al Emadi S,Masri BK,Halabi H,Badsha H,Uthman IW,Saxena R,Padyukov L,Hirata M,Matsuda K,Murakami Y,Kamatani Y,Okada Y

更新日期：2020-03-26 00:00:00

abstract：:Single-celled eukaryotes (protists) are critical players in global biogeochemical cycling of nutrients and energy in the oceans. While their roles as primary producers and grazers are well appreciated, other aspects of their life histories remain obscure due to challenges in culturing and sequencing their natural dive...

journal_title：Nature communications

authors： Seeleuthner Y,Mondy S,Lombard V,Carradec Q,Pelletier E,Wessner M,Leconte J,Mangot JF,Poulain J,Labadie K,Logares R,Sunagawa S,de Berardinis V,Salanoubat M,Dimier C,Kandels-Lewis S,Picheral M,Searson S,Tara Oceans Coor

更新日期：2018-01-22 00:00:00

abstract：:Nanoscale correlation of structural information acquisition with specific-molecule identification provides new insight for studying rare subcellular events. To achieve this correlation, scanning electron microscopy has been combined with super-resolution fluorescent microscopy, despite its destructivity when acquiring...

journal_title：Nature communications

authors： Wang F,Liu L,Yu H,Wen Y,Yu P,Liu Z,Wang Y,Li WJ

更新日期：2016-12-09 00:00:00

abstract：:As European heatwaves become more severe, summers in the United Kingdom (UK) are also getting warmer. The UK record temperature of 38.7 °C set in Cambridge in July 2019 prompts the question of whether exceeding 40 °C is now within reach. Here, we show how human influence is increasing the likelihood of exceeding 30, 3...

journal_title：Nature communications

authors： Christidis N,McCarthy M,Stott PA

更新日期：2020-06-30 00:00:00

abstract：:In November 2013, a series of earthquakes began along a mapped ancient fault system near Azle, Texas. Here we assess whether it is plausible that human activity caused these earthquakes. Analysis of both lake and groundwater variations near Azle shows that no significant stress changes were associated with the shallow...

journal_title：Nature communications

authors： Hornbach MJ,DeShon HR,Ellsworth WL,Stump BW,Hayward C,Frohlich C,Oldham HR,Olson JE,Magnani MB,Brokaw C,Luetgert JH

更新日期：2015-04-21 00:00:00

abstract：:Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed...

journal_title：Nature communications

authors： Bell CG,Gao F,Yuan W,Roos L,Acton RJ,Xia Y,Bell J,Ward K,Mangino M,Hysi PG,Wang J,Spector TD

更新日期：2018-01-02 00:00:00

abstract：:Metallic nanostructures exhibit a multitude of optical resonances associated with localized surface plasmon excitations. Recent observations of plasmonic phenomena at the sub-nanometre to atomic scale have stimulated the development of various sophisticated theoretical approaches for their description. Here instead we...

journal_title：Nature communications

authors： Mortensen NA,Raza S,Wubs M,Søndergaard T,Bozhevolnyi SI

更新日期：2014-05-02 00:00:00

abstract：:Upgrading C1 chemicals (for example, CO, CO/H2, MeOH and CO2) with C-C bond formation is essential for the synthesis of bulk chemicals. In general, these industrially important processes (for example, Fischer Tropsch) proceed at drastic reaction conditions (>250 °C; high pressure) and suffer from low selectivity, whic...

journal_title：Nature communications

authors： Dong K,Elangovan S,Sang R,Spannenberg A,Jackstell R,Junge K,Li Y,Beller M

更新日期：2016-07-05 00:00:00

abstract：:According to quantum theory, measurements generate random outcomes, in stark contrast with classical mechanics. This raises the question of whether there could exist an extension of the theory that removes this indeterminism, as suspected by Einstein, Podolsky and Rosen. Although this has been shown to be impossible, ...

journal_title：Nature communications

authors： Colbeck R,Renner R

更新日期：2011-08-02 00:00:00

abstract：:Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective, transient or lack specificity. Here we report that neutrophil...

journal_title：Nature communications

authors： Boivin G,Faget J,Ancey PB,Gkasti A,Mussard J,Engblom C,Pfirschke C,Contat C,Pascual J,Vazquez J,Bendriss-Vermare N,Caux C,Vozenin MC,Pittet MJ,Gunzer M,Meylan E

更新日期：2020-06-02 00:00:00

abstract：:Artificial photosynthesis is a vibrant field of research aiming at converting abundant, low energy molecules such as water, nitrogen or carbon dioxide into fuels or useful chemicals by means of solar energy input. Photo-electrochemical reduction of carbon dioxide is an appealing strategy, aiming at reducing the greenh...

journal_title：Nature communications

authors： Pati PB,Wang R,Boutin E,Diring S,Jobic S,Barreau N,Odobel F,Robert M

更新日期：2020-07-13 00:00:00

abstract：:Photocatalysis has not found widespread industrial adoption, in spite of decades of active research, because the challenges associated with catalyst illumination and turnover outweigh the touted advantages of replacing heat with light. A demonstration that light can control product selectivity in complex chemical reac...

journal_title：Nature communications

authors： Zhang X,Li X,Zhang D,Su NQ,Yang W,Everitt HO,Liu J

更新日期：2017-02-23 00:00:00

abstract：:Soil surface temperature, an important driver of terrestrial biogeochemical processes, depends strongly on soil albedo, which can be significantly modified by factors such as plant cover. In sparsely vegetated lands, the soil surface can be colonized by photosynthetic microbes that build biocrust communities. Here we ...

journal_title：Nature communications

authors： Couradeau E,Karaoz U,Lim HC,Nunes da Rocha U,Northen T,Brodie E,Garcia-Pichel F

更新日期：2016-01-20 00:00:00

abstract：:Single spins in the solid state offer a unique opportunity to store and manipulate quantum information, and to perform quantum-enhanced sensing of local fields and charges. Optical control of these systems using techniques developed in atomic physics has yet to exploit all the advantages of the solid state. Here we de...

journal_title：Nature communications

authors： Bennett AJ,Pooley MA,Cao Y,Sköld N,Farrer I,Ritchie DA,Shields AJ

更新日期：2013-01-01 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:The emerging monolayer transition metal dichalcogenides have provided an unprecedented material platform for miniaturized opto-electronic devices with integrated functionalities. Although excitonic light-matter interactions associated with their direct bandgaps have received tremendous research efforts, wavefront engi...

journal_title：Nature communications

authors： Qin F,Liu B,Zhu L,Lei J,Fang W,Hu D,Zhu Y,Ma W,Wang B,Shi T,Cao Y,Guan BO,Qiu CW,Lu Y,Li X

更新日期：2021-01-04 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of ...

journal_title：Nature communications

authors： Lama L,Adura C,Xie W,Tomita D,Kamei T,Kuryavyi V,Gogakos T,Steinberg JI,Miller M,Ramos-Espiritu L,Asano Y,Hashizume S,Aida J,Imaeda T,Okamoto R,Jennings AJ,Michino M,Kuroita T,Stamford A,Gao P,Meinke P,Glickman

更新日期：2019-05-21 00:00:00

abstract：:The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited th...

journal_title：Nature communications

authors： Que L,Lukacsovich D,Luo W,Földy C

更新日期：2021-01-04 00:00:00

abstract：:Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis that a gradual dec...

journal_title：Nature communications

authors： Touati SA,Buffin E,Cladière D,Hached K,Rachez C,van Deursen JM,Wassmann K

更新日期：2015-04-21 00:00:00

abstract：:The experimental investigation of quantum devices incorporating mechanical resonators has opened up new frontiers in the study of quantum mechanics at a macroscopic level. It has recently been shown that surface acoustic waves (SAWs) can be piezoelectrically coupled to superconducting qubits, and confined in high-qual...

journal_title：Nature communications

authors： Manenti R,Kockum AF,Patterson A,Behrle T,Rahamim J,Tancredi G,Nori F,Leek PJ

更新日期：2017-10-17 00:00:00

abstract：:Understanding the response of granular matter to intrusion of solid objects is key to modelling many aspects of behaviour of granular matter, including plastic flow. Here we report a general model for such a quasistatic process. Using a range of experiments, we first show that the relation between the penetration dept...

journal_title：Nature communications

authors： Kang W,Feng Y,Liu C,Blumenfeld R

更新日期：2018-03-16 00:00:00

abstract：:Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze t...

journal_title：Nature communications

authors： Chai PC,Cruchet S,Wigger L,Benton R

更新日期：2019-02-07 00:00:00

abstract：:The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker ...

journal_title：Nature communications

authors： Juan-Colás J,Parkin A,Dunn KE,Scullion MG,Krauss TF,Johnson SD

更新日期：2016-09-14 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here...

journal_title：Nature communications

authors： Viant C,Fenis A,Chicanne G,Payrastre B,Ugolini S,Vivier E

更新日期：2014-10-30 00:00:00

abstract：:In all of the diverse areas of science where waves play an important role, one of the most fundamental solutions of the corresponding wave equation is a stationary wave with constant intensity. The most familiar example is that of a plane wave propagating in free space. In the presence of any Hermitian potential, a wa...

journal_title：Nature communications

authors： Makris KG,Musslimani ZH,Christodoulides DN,Rotter S

更新日期：2015-07-08 00:00:00

abstract：:Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of ...

journal_title：Nature communications

authors： Adhireksan Z,Palermo G,Riedel T,Ma Z,Muhammad R,Rothlisberger U,Dyson PJ,Davey CA

更新日期：2017-03-30 00:00:00