Abstract:
:Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here that the protein tyrosine phosphatase SHP-1 is essential for the inhibitory function of NK cell MHC class I receptors. In the absence of SHP-1, NK cells are hyporesponsive to tumour cells in vitro and their early Ca(2+) signals are compromised. Mice without SHP-1 in NK cells are unable to reject MHC class I-deficient transplants and to control tumours in vivo. Thus, the inhibitory activity of SHP-1 is needed for setting the threshold of NK cell reactivity.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Viant C,Fenis A,Chicanne G,Payrastre B,Ugolini S,Vivier Edoi
10.1038/ncomms6108subject
Has Abstractpub_date
2014-10-30 00:00:00pages
5108issn
2041-1723pii
ncomms6108journal_volume
5pub_type
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