Abstract:
:Zea mays is an important genetic model for elucidating transcriptional networks. Uncertainties about the complete structure of mRNA transcripts limit the progress of research in this system. Here, using single-molecule sequencing technology, we produce 111,151 transcripts from 6 tissues capturing ∼70% of the genes annotated in maize RefGen_v3 genome. A large proportion of transcripts (57%) represent novel, sometimes tissue-specific, isoforms of known genes and 3% correspond to novel gene loci. In other cases, the identified transcripts have improved existing gene models. Averaging across all six tissues, 90% of the splice junctions are supported by short reads from matched tissues. In addition, we identified a large number of novel long non-coding RNAs and fusion transcripts and found that DNA methylation plays an important role in generating various isoforms. Our results show that characterization of the maize B73 transcriptome is far from complete, and that maize gene expression is more complex than previously thought.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang B,Tseng E,Regulski M,Clark TA,Hon T,Jiao Y,Lu Z,Olson A,Stein JC,Ware Ddoi
10.1038/ncomms11708subject
Has Abstractpub_date
2016-06-24 00:00:00pages
11708issn
2041-1723pii
ncomms11708journal_volume
7pub_type
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