Abstract:
:The sensory cortex participates in emotional memory but its role is poorly understood. Here we show that inactivation of the higher order auditory cortex Te2 in rats during early memory consolidation impairs remote first- and second-order fear memories but not the association between two neutral cues. Furthermore, Te2 inactivation prevents changes in the valence of such information. Following the presentation of two auditory cues previously paired with either pleasant or painful stimuli, a large percentage of cells responds to both experiences but also a small fraction of neurons responds exclusively to one of them. The latter type of neurons signals the valence rather than the salience or the motor responses associated with the stimuli, and reflects selective associative processes. Pharmacogenetic silencing of memory-activated neurons causes amnesia. Thus, Te2 represents a crucial node for the assignment of the affective value to sensory stimuli and for the storage of such information.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Grosso A,Cambiaghi M,Renna A,Milano L,Roberto Merlo G,Sacco T,Sacchetti Bdoi
10.1038/ncomms9886subject
Has Abstractpub_date
2015-12-01 00:00:00pages
8886issn
2041-1723pii
ncomms9886journal_volume
6pub_type
杂志文章abstract::Recent outbreaks of Zika, chikungunya and dengue highlight the importance of better understanding the spread of disease-carrying mosquitoes across multiple spatio-temporal scales. Traditional surveillance tools are limited by jurisdictional boundaries and cost constraints. Here we show how a scalable citizen science s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00914-9
更新日期:2017-10-24 00:00:00
abstract::In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00452-4
更新日期:2017-09-19 00:00:00
abstract::The emergence of larger brains with large numbers of neurons is an evolutionary innovation in mammals and birds. However, the corresponding changes in cortical developmental programmes during amniote evolution are poorly understood. Here we examine the cortical development of Madagascar ground geckos, and report uniqu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3206
更新日期:2013-01-01 00:00:00
abstract::The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging and prevent thorough statistical analyses in developmental biology. Here, instead of deploying massive storage and computing power, we exploit the spherical geometry of zebrafish embryos by computi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3207
更新日期:2013-01-01 00:00:00
abstract::Daily-life foldable items, such as popup tents, the curved origami sculptures exhibited in the Museum of Modern Art of New York, overstrained bicycle wheels, released bilayered microrings and strained cyclic macromolecules, are made of rings buckled or folded in tridimensional saddle shapes. Surprisingly, despite thei...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2311
更新日期:2012-01-01 00:00:00
abstract::Circadian clocks generate reliable ~24-h rhythms despite being based on stochastic biochemical reactions. The circadian clock in Synechococcus elongatus uses a post-translational oscillator that cycles deterministically in a test tube. Because the volume of a single bacterial cell is much smaller than a macroscopic re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05109-4
更新日期:2018-08-01 00:00:00
abstract::The description of ultrafast nonadiabatic chemical dynamics during molecular photo-transformations remains challenging because electronic and nuclear configurations impact each other and cannot be treated independently. Here we gain experimental insights, beyond the Born-Oppenheimer approximation, into the light-induc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15342
更新日期:2017-05-24 00:00:00
abstract::Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18200-6
更新日期:2020-09-07 00:00:00
abstract::Coordination of ciliary beating is essential to ensure mucus clearance in the airway tract. The orientation and synchronization of ciliary motion responds in part to the organization of the underlying cytoskeletal networks. Using electron tomography on mouse trachea, we show that basal bodies are collectively hooked a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5888
更新日期:2014-09-12 00:00:00
abstract::The Aharonov-Bohm effect is one of the most intriguing phenomena in both classical and quantum physics, and associates with a number of important and fundamental issues in quantum mechanics. The Aharonov-Bohm effects of charged particles have been experimentally demonstrated and found applications in various fields. R...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4225
更新日期:2014-01-01 00:00:00
abstract::Neurofilaments are intermediate filaments assembled from the subunits neurofilament-low, neurofilament-medium and neurofilament-high. In axons, parallel neurofilaments form a nematic liquid-crystal hydrogel with network structure arising from interactions between the neurofilaments' C-terminal sidearms. Here we report...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3224
更新日期:2013-01-01 00:00:00
abstract::It is well known that a topologically protected gapless state appears at an interface between a topological insulator and an ordinary insulator; however, the physics of the interface between a topological insulator and a metal has largely been left unexplored. Here we report a novel phenomenon termed topological proxi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7547
更新日期:2015-03-12 00:00:00
abstract::Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to function as competitive endogenous RNAs (ceRNAs) by sponging specific microRNAs. Here, we report the first spatially resolved cellular expr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18355-2
更新日期:2020-09-11 00:00:00
abstract::Alkaline-urea aqueous solvent system provides a novel and important approach for the utilization of polysaccharide. As one of the most important polysaccharide, chitosan can be well dissolved in this solvent system, and the resultant hydrogel material possesses unique and excellent properties. Thus the sound understan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12033
更新日期:2016-06-23 00:00:00
abstract::Epilepsy-the propensity toward recurrent, unprovoked seizures-is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14896
更新日期:2017-04-04 00:00:00
abstract::Highly pure semiconducting single-walled carbon nanotubes (SWNTs) are essential for the next generation of electronic devices, such as field-effect transistors and photovoltaic applications; however, contamination by metallic SWNTs reduces the efficiency of their associated devices. Here we report a simple and efficie...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6041
更新日期:2014-10-03 00:00:00
abstract::There is enormous interest in engineering topological photonic systems. Despite intense activity, most works on topological photonic states (and more generally bosonic states) amount in the end to replicating a well-known fermionic single-particle Hamiltonian. Here we show how the squeezing of light can lead to the fo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10779
更新日期:2016-03-02 00:00:00
abstract::Various melting-related phenomena (like surface melting, size dependence of melting temperature, melting of few nm-size particles and overheating at a very fast heating rate) are of great fundamental and applied interest, although the corresponding theory is still lacking. Here we develop an advanced phase-field theor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1275
更新日期:2011-01-01 00:00:00
abstract::Stimuli-responsive hydrogel actuators have promising applications in various fields. However, the typical hydrogel actuation relies on the swelling and de-swelling process caused by osmotic-pressure changes, which is slow and normally requires the presence of water environment. Herein, we report a light-powered in-air...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17775-4
更新日期:2020-08-10 00:00:00
abstract::Microbial symbiosis is integral to plant growth and reproduction, but its contribution to global patterns of plant distribution is unknown. Legumes (Fabaceae) are a diverse and widely distributed plant family largely dependent on symbiosis with nitrogen-fixing rhizobia, which are acquired from soil after germination. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14790
更新日期:2017-04-07 00:00:00
abstract::LPMO (lytic polysaccharide monooxygenase) represents a unique paradigm of cellulosic biomass degradation by an oxidative mechanism. Understanding the role of LPMO in deconstructing crystalline cellulose is fundamental to the enzyme's biological function and will help to specify the use of LPMO in biorefinery applicati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01028-y
更新日期:2017-10-12 00:00:00
abstract::In quantizing magnetic fields, graphene superlattices exhibit a complex fractal spectrum often referred to as the Hofstadter butterfly. It can be viewed as a collection of Landau levels that arise from quantization of Brown-Zak minibands recurring at rational (p/q) fractions of the magnetic flux quantum per superlatti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19604-0
更新日期:2020-11-13 00:00:00
abstract::While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15134
更新日期:2017-05-08 00:00:00
abstract::It is vital to design effective nitrogen fixation systems that operate under mild conditions, and to this end we recently reported an example of the catalytic formation of ammonia using a dinitrogen-bridged dimolybdenum complex bearing a pincer ligand, where up to twenty three equivalents of ammonia were produced base...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4737
更新日期:2014-04-28 00:00:00
abstract::Saturn's largest moon Titan has a substantial nitrogen-methane atmosphere, with strong seasonal effects, including formation of winter polar vortices. Following Titan's 2009 northern spring equinox, peak solar heating moved to the northern hemisphere, initiating south-polar subsidence and winter polar vortex formation...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01839-z
更新日期:2017-11-21 00:00:00
abstract::The development of integrated photonics and lab-on-a-chip platforms for environmental and biomedical diagnostics demands ultraviolet electroluminescent materials with high mechanical, chemical and environmental stability and almost complete compatibility with existing silicon technology. Here we report the realization...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1683
更新日期:2012-02-21 00:00:00
abstract::Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble proteins in lysosomes. CMA contributes to cellular quality control and is activated as part of the cellular response to different stressors. Defective CMA has been identified in ageing and different age-related diseases. Until n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1393
更新日期:2011-07-12 00:00:00
abstract::Chemotherapy remains a mainstay of cancer treatment but its use is often limited by the development of adverse reactions. Severe loss of body weight (cachexia) is a frequent cause of death in cancer patients and is exacerbated by chemotherapy. We show that genetic inactivation of vascular endothelial growth factor (VE...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12528
更新日期:2016-08-19 00:00:00
abstract::Engagement of the T cell receptor (TCR) by stimulatory ligand results in the rapid formation of microclusters at sites of T cell activation. Whereas microclusters have been studied extensively using confocal microscopy, the spatial and kinetic relationships of their signaling components have not been well characterize...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08064-2
更新日期:2019-01-17 00:00:00
abstract::Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1803
更新日期:2012-05-01 00:00:00