Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation.

abstract：:Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate functional nanomachines by programming the folding of a single-stranded DNA template strand into three-dimensional (3D) nanostructures, designed to be precisely motion-controlled. Although two-dimensional (2D) imaging of DNA nanoma...

journal_title：Nature communications

authors： Lei D,Marras AE,Liu J,Huang CM,Zhou L,Castro CE,Su HJ,Ren G

更新日期：2018-02-09 00:00:00

abstract：:In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...

journal_title：Nature communications

authors： Kawashima K,Takaoka T,Kimura H,Saito K,Ishikita H

更新日期：2018-03-28 00:00:00

abstract：:The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation induced by elongation factor G (EF-G) with tRNAs trapped in chimeric states wi...

journal_title：Nature communications

authors： Adio S,Senyushkina T,Peske F,Fischer N,Wintermeyer W,Rodnina MV

更新日期：2015-06-15 00:00:00

abstract：:The insulator-metal transition (IMT) of vanadium dioxide (VO2) has remained a long-standing challenge in correlated electron physics since its discovery five decades ago. Most interpretations of experimental observations have implicitly assumed a homogeneous material response. Here we reveal inhomogeneous behaviour of...

journal_title：Nature communications

authors： O'Callahan BT,Jones AC,Hyung Park J,Cobden DH,Atkin JM,Raschke MB

更新日期：2015-04-21 00:00:00

abstract：:Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms that prevent transcriptional interference are not well understood. Here ...

journal_title：Nature communications

authors： Yu X,Martin PGP,Michaels SD

更新日期：2019-09-25 00:00:00

abstract：:Pseudomonas aeruginosa, an opportunistic pathogen of humans, uses quorum sensing (QS) to regulate the production of extracellular products that can benefit all members of the population. P. aeruginosa can police QS-deficient cheaters by producing hydrogen cyanide, which is also QS regulated; however, the mechanism by ...

journal_title：Nature communications

authors： Yan H,Asfahl KL,Li N,Sun F,Xiao J,Shen D,Dandekar AA,Wang M

更新日期：2019-11-01 00:00:00

abstract：:Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut mic...

journal_title：Nature communications

authors： Vojinovic D,Radjabzadeh D,Kurilshikov A,Amin N,Wijmenga C,Franke L,Ikram MA,Uitterlinden AG,Zhernakova A,Fu J,Kraaij R,van Duijn CM

更新日期：2019-12-20 00:00:00

abstract：:Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-small cell lung cancer...

journal_title：Nature communications

authors： Collier TL,Normandin MD,Stephenson NA,Livni E,Liang SH,Wooten DW,Esfahani SA,Stabin MG,Mahmood U,Chen J,Wang W,Maresca K,Waterhouse RN,El Fakhri G,Richardson P,Vasdev N

更新日期：2017-06-08 00:00:00

abstract：:The direct response of the tropical mixed layer to near-inertial waves (NIWs) has only rarely been observed. Here, we present upper-ocean turbulence data that provide evidence for a strongly elevated vertical diffusive heat flux across the base of the mixed layer in the presence of a NIW, thereby cooling the mixed lay...

journal_title：Nature communications

authors： Hummels R,Dengler M,Rath W,Foltz GR,Schütte F,Fischer T,Brandt P

更新日期：2020-07-31 00:00:00

abstract：:A crumpled sheet of paper displays an intricate pattern of creases and point-like singular structures, termed d-cones. It is typically assumed that elongated creases form when ridges connecting two d-cones fold beyond the material yielding threshold, and scarring is thus a by-product of the folding dynamics that seek ...

journal_title：Nature communications

authors： Gottesman O,Efrati E,Rubinstein SM

更新日期：2015-06-11 00:00:00

abstract：:Tibetan wheat is grown under environmental constraints at high-altitude conditions, but its underlying adaptation mechanism remains unknown. Here, we present a draft genome sequence of a Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) accession Zang1817 and re-sequence 245 wheat accessions, including w...

journal_title：Nature communications

authors： Guo W,Xin M,Wang Z,Yao Y,Hu Z,Song W,Yu K,Chen Y,Wang X,Guan P,Appels R,Peng H,Ni Z,Sun Q

更新日期：2020-10-08 00:00:00

abstract：:Topological insulators represent a new quantum state of matter that are insulating in the bulk but metallic on the edge or surface. In the Dirac surface state, it is well-established that the electron spin is locked with the crystal momentum. Here we report a new phenomenon of the spin texture locking with the orbital...

journal_title：Nature communications

authors： Xie Z,He S,Chen C,Feng Y,Yi H,Liang A,Zhao L,Mou D,He J,Peng Y,Liu X,Liu Y,Liu G,Dong X,Yu L,Zhang J,Zhang S,Wang Z,Zhang F,Yang F,Peng Q,Wang X,Chen C,Xu Z,Zhou XJ

更新日期：2014-02-28 00:00:00

abstract：:The evolutionary and environmental factors that shape fungal biogeography are incompletely understood. Here, we assemble a large dataset consisting of previously generated mycobiome data linked to specific geographical locations across the world. We use this dataset to describe the distribution of fungal taxa and to l...

journal_title：Nature communications

authors： Větrovský T,Kohout P,Kopecký M,Machac A,Man M,Bahnmann BD,Brabcová V,Choi J,Meszárošová L,Human ZR,Lepinay C,Lladó S,López-Mondéjar R,Martinović T,Mašínová T,Morais D,Navrátilová D,Odriozola I,Štursová M,Švec K,Tl

更新日期：2019-11-13 00:00:00

abstract：:Polymorphism is a remarkable concept in chemistry, materials science, computer science, and biology. Whether it is the ability of a material to exist in two or more crystal structures, a single interface connecting to two different entities, or alternative phenotypes of an organism, polymorphism determines function an...

journal_title：Nature communications

authors： Li L,Salamończyk M,Shadpour S,Zhu C,Jákli A,Hegmann T

更新日期：2018-02-19 00:00:00

abstract：:Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifesty...

journal_title：Nature communications

authors： Young AI,Wauthier F,Donnelly P

更新日期：2016-09-06 00:00:00

abstract：:The application of electron microscopy to hydrated biological samples has been limited by high-vacuum operating conditions. Traditional methods utilize harsh and laborious sample dehydration procedures, often leading to structural artefacts and creating difficulties for correlating results with high-resolution fluores...

journal_title：Nature communications

authors： Wojcik M,Hauser M,Li W,Moon S,Xu K

更新日期：2015-06-11 00:00:00

abstract：:Stimuli-responsive hydrogel actuators have promising applications in various fields. However, the typical hydrogel actuation relies on the swelling and de-swelling process caused by osmotic-pressure changes, which is slow and normally requires the presence of water environment. Herein, we report a light-powered in-air...

journal_title：Nature communications

authors： Li M,Wang X,Dong B,Sitti M

更新日期：2020-08-10 00:00:00

abstract：:The future of coastal wetlands and their ecological value depend on their capacity to adapt to the interacting effects of human impacts and sea-level rise. Even though extensive wetland loss due to submergence is a possible scenario, its magnitude is highly uncertain due to limited understanding of hydrodynamic and bi...

journal_title：Nature communications

authors： Rodríguez JF,Saco PM,Sandi S,Saintilan N,Riccardi G

更新日期：2017-07-13 00:00:00

abstract：:Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315...

journal_title：Nature communications

authors： Kernstock S,Davydova E,Jakobsson M,Moen A,Pettersen S,Mælandsmo GM,Egge-Jacobsen W,Falnes PØ

更新日期：2012-01-01 00:00:00

abstract：:Oriented assemblies of functional nanoparticles, with the aid of external physical and chemical driving forces, have been prepared on two-dimensional solid substrates. It is challengeable, however, to achieve three-dimensional assembly directly in solution, owing to thermal fluctuations and free diffusion. Here we des...

journal_title：Nature communications

authors： Kim K,Han HS,Choi I,Lee C,Hong S,Suh SH,Lee LP,Kang T

更新日期：2013-01-01 00:00:00

abstract：:Cytochrome P450 monooxygenases are versatile heme-thiolate enzymes that catalyze a wide range of reactions. Self-sufficient cytochrome P450 enzymes contain the redox partners in a single polypeptide chain. Here, we present the crystal structure of full-length CYP116B46, a self-sufficient P450. The continuous polypepti...

journal_title：Nature communications

authors： Zhang L,Xie Z,Liu Z,Zhou S,Ma L,Liu W,Huang JW,Ko TP,Li X,Hu Y,Min J,Yu X,Guo RT,Chen CC

更新日期：2020-05-29 00:00:00

abstract：:Express delivery services are booming in both developed and emerging economies due to their low cost, convenience, and the fast growth in online shopping. The increasing environmental impacts of express delivery services and mitigation potentials, however, remain largely unexplored. Here we addressed such a gap for Ch...

journal_title：Nature communications

authors： Kang P,Song G,Xu M,Miller TR,Wang H,Zhang H,Liu G,Zhou Y,Ren J,Zhong R,Duan H

更新日期：2021-01-19 00:00:00

abstract：:We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mutations fall into a ...

journal_title：Nature communications

authors： New AM,Lehner B

更新日期：2019-08-14 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00

abstract：:Symmetry and topology are two fundamental aspects of many quantum states of matter. Recently new topological materials, higher-order topological insulators, were discovered, featuring bulk-edge-corner correspondence that goes beyond the conventional topological paradigms. Here we discover experimentally that the nonsy...

journal_title：Nature communications

authors： Zhang X,Lin ZK,Wang HX,Xiong Z,Tian Y,Lu MH,Chen YF,Jiang JH

更新日期：2020-01-03 00:00:00

abstract：:The dual role played by symmetry in many-body physics manifests itself through two fundamental mechanisms: spontaneous symmetry breaking and topological symmetry protection. These two concepts, ubiquitous in both condensed matter and high energy physics, have been applied successfully in the last decades to unravel a ...

journal_title：Nature communications

authors： González-Cuadra D,Bermudez A,Grzybowski PR,Lewenstein M,Dauphin A

更新日期：2019-06-19 00:00:00

abstract：:Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...

journal_title：Nature communications

authors： Wu Y,Subotnik JE

更新日期：2021-01-29 00:00:00

abstract：:Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues either during nervous system development or the establishment of the vascular system. This was clearly demonstrated for netrin-1 via its interaction with the receptors DCC and UNC5s. However, mainly based on shared homologies wi...

journal_title：Nature communications

authors： Reuten R,Patel TR,McDougall M,Rama N,Nikodemus D,Gibert B,Delcros JG,Prein C,Meier M,Metzger S,Zhou Z,Kaltenberg J,McKee KK,Bald T,Tüting T,Zigrino P,Djonov V,Bloch W,Clausen-Schaumann H,Poschl E,Yurchenco PD,Eh

更新日期：2016-11-30 00:00:00

abstract：:Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localizat...

journal_title：Nature communications

authors： Walton T,Wu H,Brown A

更新日期：2021-01-20 00:00:00

abstract：:Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads. Here we report a 'synapse microarray' technology that enables ultra-sensitive, high-throughput and quantitative screening of synaptogenesis. Our platform enables ...

journal_title：Nature communications

authors： Shi P,Scott MA,Ghosh B,Wan D,Wissner-Gross Z,Mazitschek R,Haggarty SJ,Yanik MF

更新日期：2011-10-25 00:00:00