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An artificial primitive mimic of the Gramicidin-A channel.

Abstract：

:Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or 'T-channel' forming compound (TCT), having similar constitutional functions as the natural gAs. As in gA channels, the carbonyl moieties of the TCT, which point toward the T-channel core and surround the transport direction, are solvated by water. The net-dipolar alignment of water molecules along the chiral pore surfaces influences the conduction of protons/ions, envisioned to diffuse along dipolar hydrophilic pathways. Theoretical simulations and experimental assays reveal that the conduction through the T-channel, similar to that in gA, presents proton/water conduction, cation/anion selectivity and large open channel-conductance states. T-channels--associating supramolecular chirality with dipolar water alignment--represent an artificial primitive mimic of gA.

journal_name

Nat Commun

journal_title

Nature communications

authors

Barboiu M,Le Duc Y,Gilles A,Cazade PA,Michau M,Marie Legrand Y,van der Lee A,Coasne B,Parvizi P,Post J,Fyles T

doi

10.1038/ncomms5142

subject

Has Abstract

pub_date

2014-06-26 00:00:00

pages

4142

issn

2041-1723

pii

ncomms5142

journal_volume

5

pub_type

杂志文章

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