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Metaxins are core components of mitochondrial transport adaptor complexes.

Abstract：

:Trafficking of mitochondria into dendrites and axons plays an important role in the physiology and pathophysiology of neurons. Mitochondrial outer membrane protein Miro and adaptor proteins TRAKs/Milton link mitochondria to molecular motors. Here we show that metaxins MTX-1 and MTX-2 contribute to mitochondrial transport into both dendrites and axons of C. elegans neurons. MTX1/2 bind to MIRO-1 and kinesin light chain KLC-1, forming a complex to mediate kinesin-1-based movement of mitochondria, in which MTX-1/2 are essential and MIRO-1 plays an accessory role. We find that MTX-2, MIRO-1, and TRAK-1 form another distinct adaptor complex to mediate dynein-based transport. Additionally, we show that failure of mitochondrial trafficking in dendrites causes age-dependent dendrite degeneration. We propose that MTX-2 and MIRO-1 form the adaptor core for both motors, while MTX-1 and TRAK-1 specify each complex for kinesin-1 and dynein, respectively. MTX-1 and MTX-2 are also required for mitochondrial transport in human neurons, indicative of their evolutionarily conserved function.

journal_name

Nat Commun

journal_title

Nature communications

authors

Zhao Y,Song E,Wang W,Hsieh CH,Wang X,Feng W,Wang X,Shen K

doi

10.1038/s41467-020-20346-2

subject

Has Abstract

pub_date

2021-01-04 00:00:00

pages

83

issue

1

issn

2041-1723

pii

10.1038/s41467-020-20346-2

journal_volume

12

pub_type

杂志文章

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