Diverse protein assembly driven by metal and chelating amino acids with selectivity and tunability.

abstract：:Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex CST (CTC1-STN1-TEN1...

journal_title：Nature communications

authors： Feng X,Hsu SJ,Bhattacharjee A,Wang Y,Diao J,Price CM

更新日期：2018-07-19 00:00:00

abstract：:Among calcareous nannofossils, important primary producers in Jurassic and Cretaceous oceans, nannoconids were carbonate rock-forming organisms. During the late Barremian and early Aptian (~126 to 122 million years ago), nannoconids went through a crisis culminating during the Oceanic Anoxic Event 1a. Here we present ...

journal_title：Nature communications

authors： Mutterlose J,Bottini C

更新日期：2013-01-01 00:00:00

abstract：:Achieving control over the directionality of active colloids is essential for their use in practical applications such as cargo carriers in microfluidic devices. So far, guidance of spherical Janus colloids was mainly realized using specially engineered magnetic multilayer coatings combined with external magnetic fiel...

journal_title：Nature communications

authors： Simmchen J,Katuri J,Uspal WE,Popescu MN,Tasinkevych M,Sánchez S

更新日期：2016-02-09 00:00:00

abstract：:The ever-increasing speed and resolution of modern microscopes make the storage and post-processing of images challenging and prevent thorough statistical analyses in developmental biology. Here, instead of deploying massive storage and computing power, we exploit the spherical geometry of zebrafish embryos by computi...

journal_title：Nature communications

authors： Schmid B,Shah G,Scherf N,Weber M,Thierbach K,Campos CP,Roeder I,Aanstad P,Huisken J

更新日期：2013-01-01 00:00:00

abstract：:Predicting ecological effects of contaminants remains challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosystem function relationships. We evaluate responses of experimental pond ecosystems to standardized concentrations of 12 pesticides, nested in four pesticide classes a...

journal_title：Nature communications

authors： Rumschlag SL,Mahon MB,Hoverman JT,Raffel TR,Carrick HJ,Hudson PJ,Rohr JR

更新日期：2020-12-10 00:00:00

abstract：:There is a multi-billion dollar global industry dedicated to feeding wild birds in residential gardens. This extraordinary boost to food resources is almost certainly reshaping entire bird communities, yet the large-scale, long-term impacts on community ecology remain unknown. Here we reveal a 40-year transformation o...

journal_title：Nature communications

authors： Plummer KE,Risely K,Toms MP,Siriwardena GM

更新日期：2019-05-21 00:00:00

abstract：:Electron transport in two-dimensional conducting materials such as graphene, with dominant electron-electron interaction, exhibits unusual vortex flow that leads to a nonlocal current-field relation (negative resistance), distinct from the classical Ohm's law. The transport behavior of these materials is best describe...

journal_title：Nature communications

authors： Mayzel J,Steinberg V,Varshney A

更新日期：2019-02-26 00:00:00

abstract：:Two-dimensional metallic transition metal dichalcogenides are emerging as prototypes for uncovering fundamental physical phenomena, such as superconductivity and charge-density waves, as well as for engineering-related applications. However, the batch production of such envisioned transition metal dichalcogenides rema...

journal_title：Nature communications

authors： Shi J,Wang X,Zhang S,Xiao L,Huan Y,Gong Y,Zhang Z,Li Y,Zhou X,Hong M,Fang Q,Zhang Q,Liu X,Gu L,Liu Z,Zhang Y

更新日期：2017-10-16 00:00:00

abstract：:The high Aβ42/Aβ40 production ratio is a hallmark of familial Alzheimer's disease, which can be caused by mutations in the amyloid precursor protein (APP). The C-terminus of Aβ is generated by γ-secretase cleavage within the transmembrane domain of APP (APPTM), a process that is primed by an initial ε-cleavage at eith...

journal_title：Nature communications

authors： Chen W,Gamache E,Rosenman DJ,Xie J,Lopez MM,Li YM,Wang C

更新日期：2014-01-01 00:00:00

abstract：:Human Bestrophin1 (hBest1) is a Ca2+-activated Cl- channel in retinal pigment epithelium (RPE) essential for retina physiology, and its mutation results in retinal degenerative diseases that have no available treatments. Here, we discover that hBest1's channel activity in human RPE is significantly enhanced by adenosi...

journal_title：Nature communications

authors： Zhang Y,Kittredge A,Ward N,Ji C,Chen S,Yang T

更新日期：2018-08-07 00:00:00

abstract：:Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca(2+) blocks intercellular communication during tissue injury, we determined the X-ray crystal structures of...

journal_title：Nature communications

authors： Bennett BC,Purdy MD,Baker KA,Acharya C,McIntire WE,Stevens RC,Zhang Q,Harris AL,Abagyan R,Yeager M

更新日期：2016-01-12 00:00:00

abstract：:Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of diseases includes serious or fatal neurological presentations such as Leigh syndrome and there are very limited evidence-based treatment options available. Here...

journal_title：Nature communications

authors： Ehinger JK,Piel S,Ford R,Karlsson M,Sjövall F,Frostner EÅ,Morota S,Taylor RW,Turnbull DM,Cornell C,Moss SJ,Metzsch C,Hansson MJ,Fliri H,Elmér E

更新日期：2016-08-09 00:00:00

abstract：:Thermal melanism theory states that dark-colored ectotherm organisms are at an advantage at low temperature due to increased warming. This theory is generally supported for ectotherm animals, however, the function of colors in the fungal kingdom is largely unknown. Here, we test whether the color lightness of mushroom...

journal_title：Nature communications

authors： Krah FS,Büntgen U,Schaefer H,Müller J,Andrew C,Boddy L,Diez J,Egli S,Freckleton R,Gange AC,Halvorsen R,Heegaard E,Heideroth A,Heibl C,Heilmann-Clausen J,Høiland K,Kar R,Kauserud H,Kirk PM,Kuyper TW,Krisai-Greilhub

更新日期：2019-06-28 00:00:00

abstract：:Alkenes are fundamental functionalities in nature and highly useful intermediates in organic synthesis, medicinal chemistry and material sciences. Transition-metal-catalyzed Heck couplings with organic halides as electrophiles have been established as a powerful protocol for the synthesis of this valuable building blo...

journal_title：Nature communications

authors： Lv L,Zhu D,Li CJ

更新日期：2019-02-12 00:00:00

abstract：:Microbial symbiosis is integral to plant growth and reproduction, but its contribution to global patterns of plant distribution is unknown. Legumes (Fabaceae) are a diverse and widely distributed plant family largely dependent on symbiosis with nitrogen-fixing rhizobia, which are acquired from soil after germination. ...

journal_title：Nature communications

authors： Simonsen AK,Dinnage R,Barrett LG,Prober SM,Thrall PH

更新日期：2017-04-07 00:00:00

abstract：:Chemical utilization of vast fossil and renewable feedstocks of methane remains one of the most important challenges of modern chemistry. Herein, we report direct and selective methane photocatalytic oxidation at ambient conditions into carbon monoxide, which is an important chemical intermediate and a platform molecu...

journal_title：Nature communications

authors： Yu X,De Waele V,Löfberg A,Ordomsky V,Khodakov AY

更新日期：2019-02-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Barlow JT,Bogatyrev SR,Ismagilov RF

更新日期：2020-07-06 00:00:00

abstract：:Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize 'eat me' signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the intracellular sign...

journal_title：Nature communications

authors： Nakaya M,Tajima M,Kosako H,Nakaya T,Hashimoto A,Watari K,Nishihara H,Ohba M,Komiya S,Tani N,Nishida M,Taniguchi H,Sato Y,Matsumoto M,Tsuda M,Kuroda M,Inoue K,Kurose H

更新日期：2013-01-01 00:00:00

abstract：:Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we repo...

journal_title：Nature communications

authors： Zhu X,Guo Y,Cheng H,Dai J,An X,Zhao J,Tian K,Wei S,Cheng Zeng X,Wu C,Xie Y

更新日期：2016-04-04 00:00:00

abstract：:In the original version of this Article, an additional double-headed arrow was inadvertently included within Fig. 3e. This error has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Gokhale S,Conwill A,Ranjan T,Gore J

更新日期：2019-02-12 00:00:00

abstract：:Sepsis is a life-threatening condition triggered by a dysregulated host response to microbial infection resulting in vascular dysfunction, organ failure and death. Here we provide a semi-quantitative atlas of the murine vascular cell-surface proteome at the organ level, and how it changes during sepsis. Using in vivo ...

journal_title：Nature communications

authors： Toledo AG,Golden G,Campos AR,Cuello H,Sorrentino J,Lewis N,Varki N,Nizet V,Smith JW,Esko JD

更新日期：2019-10-11 00:00:00

abstract：:The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinants and the structural and functional consequences of such inter...

journal_title：Nature communications

authors： Ait-Bouziad N,Lv G,Mahul-Mellier AL,Xiao S,Zorludemir G,Eliezer D,Walz T,Lashuel HA

更新日期：2017-11-22 00:00:00

abstract：:Naturally heat-resistant coral populations hold significant potential for facilitating coral reef survival under rapid climate change. However, it remains poorly understood whether they can acclimatize to ocean warming when superimposed on their already thermally-extreme habitats. Furthermore, it is unknown whether th...

journal_title：Nature communications

authors： Schoepf V,Carrion SA,Pfeifer SM,Naugle M,Dugal L,Bruyn J,McCulloch MT

更新日期：2019-09-17 00:00:00

abstract：:Profound global loss of DNA methylation is a hallmark of many cancers. One potential consequence of this is the reactivation of transposable elements (TEs) which could stimulate the immune system via cell-intrinsic antiviral responses. Here, we develop REdiscoverTE, a computational method for quantifying genome-wide T...

journal_title：Nature communications

authors： Kong Y,Rose CM,Cass AA,Williams AG,Darwish M,Lianoglou S,Haverty PM,Tong AJ,Blanchette C,Albert ML,Mellman I,Bourgon R,Greally J,Jhunjhunwala S,Chen-Harris H

更新日期：2019-11-19 00:00:00

abstract：:Problematic microfossils dominate the palaeontological record between the Great Oxidation Event 2.4 billion years ago (Ga) and the last Palaeoproterozoic iron formations, deposited 500-600 million years later. These fossils are often associated with iron-rich sedimentary rocks, but their affinities, metabolism, and, h...

journal_title：Nature communications

authors： Lepot K,Addad A,Knoll AH,Wang J,Troadec D,Béché A,Javaux EJ

更新日期：2017-03-23 00:00:00

abstract：:Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four devel...

journal_title：Nature communications

authors： Skvortsova K,Tarbashevich K,Stehling M,Lister R,Irimia M,Raz E,Bogdanovic O

更新日期：2019-07-11 00:00:00

abstract：:It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable ...

journal_title：Nature communications

authors： Huang CG,Zhang ZD,Chacron MJ

更新日期：2016-04-18 00:00:00

abstract：:Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1-FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial-specific deletion of either...

journal_title：Nature communications

authors： Kim YH,Choi J,Yang MJ,Hong SP,Lee CK,Kubota Y,Lim DS,Koh GY

更新日期：2019-02-19 00:00:00

abstract：:High-angle grain boundaries are always the preferential fatigue cracking sites, while the intrinsic fatigue cracking mechanism of coherent twin boundary remains elusive. Here we systematically investigate the fatigue cracking behaviours of copper bicrystals with a coherent twin boundary as their sole internal boundary...

journal_title：Nature communications

authors： Li LL,Zhang ZJ,Zhang P,Wang ZG,Zhang ZF

更新日期：2014-03-26 00:00:00

abstract：:Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide association analysis of self-reported morningness, followed by analyses of biolog...

journal_title：Nature communications

authors： Hu Y,Shmygelska A,Tran D,Eriksson N,Tung JY,Hinds DA

更新日期：2016-02-02 00:00:00