Direct dehydrogenative alkyl Heck-couplings of vinylarenes with umpolung aldehydes catalyzed by nickel.

abstract：:Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...

journal_title：Nature communications

authors： Cerna R,Léger Y,Paraïso TK,Wouters M,Morier-Genoud F,Portella-Oberli MT,Deveaud B

更新日期：2013-01-01 00:00:00

abstract：:Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organe...

journal_title：Nature communications

authors： Alzahofi N,Welz T,Robinson CL,Page EL,Briggs DA,Stainthorp AK,Reekes J,Elbe DA,Straub F,Kallemeijn WW,Tate EW,Goff PS,Sviderskaya EV,Cantero M,Montoliu L,Nedelec F,Miles AK,Bailly M,Kerkhoff E,Hume AN

更新日期：2020-07-13 00:00:00

abstract：:Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage of COPI vesicle formation. Here, we find that PA with vary...

journal_title：Nature communications

authors： Park SY,Yang JS,Li Z,Deng P,Zhu X,Young D,Ericsson M,Andringa RLH,Minnaard AJ,Zhu C,Sun F,Moody DB,Morris AJ,Fan J,Hsu VW

更新日期：2019-07-30 00:00:00

abstract：:Enterobacteria, especially Escherichia coli, are abundant in patients with inflammatory bowel disease or colorectal cancer (CRC). However, it is unclear whether cancer is promoted by inflammation-induced expansion of E. coli and/or changes in expression of specific microbial genes. Here we use longitudinal (2, 12 and ...

journal_title：Nature communications

authors： Arthur JC,Gharaibeh RZ,Mühlbauer M,Perez-Chanona E,Uronis JM,McCafferty J,Fodor AA,Jobin C

更新日期：2014-09-03 00:00:00

abstract：:Polymersomes are bilayer vesicles, self-assembled from amphiphilic block copolymers. They are versatile nanocapsules with adjustable properties, such as flexibility, permeability, size and functionality. However, so far no methodological approach to control their shape exists. Here we demonstrate a mechanistically ful...

journal_title：Nature communications

authors： Rikken RS,Engelkamp H,Nolte RJ,Maan JC,van Hest JC,Wilson DA,Christianen PC

更新日期：2016-08-25 00:00:00

abstract：:Recent density-functional theory calculations suggest that codoping TiO2 with donor-acceptor pairs is more effective than monodoping for improving photoelectrochemical water-splitting performance because codoping can reduce charge recombination, improve material quality, enhance light absorption and increase solubilit...

journal_title：Nature communications

authors： Cho IS,Lee CH,Feng Y,Logar M,Rao PM,Cai L,Kim DR,Sinclair R,Zheng X

更新日期：2013-01-01 00:00:00

abstract：:Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtB...

journal_title：Nature communications

authors： Shooshtarizadeh P,Helness A,Vadnais C,Brouwer N,Beauchemin H,Chen R,Bagci H,Staal FJT,Coté JF,Möröy T

更新日期：2019-03-20 00:00:00

abstract：:New Zealand moa (Aves: Dinornithiformes) are the only late Quaternary megafauna whose extinction was clearly caused by humans. New Zealand offers the best opportunity to estimate the number of people involved in a megafaunal extinction event because, uniquely, both the Polynesian settlement of New Zealand and moa exti...

journal_title：Nature communications

authors： Holdaway RN,Allentoft ME,Jacomb C,Oskam CL,Beavan NR,Bunce M

更新日期：2014-11-07 00:00:00

abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

journal_title：Nature communications

authors： Yan C,Wu S,Pocetti C,Bai L

更新日期：2016-03-24 00:00:00

abstract：:Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...

journal_title：Nature communications

authors： Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

更新日期：2015-07-28 00:00:00

abstract：:New capabilities at X-ray free-electron laser facilities allow the generation of two-colour femtosecond X-ray pulses, opening the possibility of performing ultrafast studies of X-ray-induced phenomena. Particularly, the experimental realization of hetero-site-specific X-ray-pump/X-ray-probe spectroscopy is of special ...

journal_title：Nature communications

authors： Picón A,Lehmann CS,Bostedt C,Rudenko A,Marinelli A,Osipov T,Rolles D,Berrah N,Bomme C,Bucher M,Doumy G,Erk B,Ferguson KR,Gorkhover T,Ho PJ,Kanter EP,Krässig B,Krzywinski J,Lutman AA,March AM,Moonshiram D,Ray D,

更新日期：2016-05-23 00:00:00

abstract：:Single-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal-organic frameworks (MOFs). The pyrolysis of SiO2@MOF c...

journal_title：Nature communications

authors： Jiao L,Zhang R,Wan G,Yang W,Wan X,Zhou H,Shui J,Yu SH,Jiang HL

更新日期：2020-06-05 00:00:00

abstract：:In eukaryotes, telomeres cap chromosome ends to maintain genomic stability. Failure to maintain telomeres leads to their progressive erosion and eventually triggers replicative senescence, a pathway that protects against unrestricted cell proliferation. However, the mechanisms underlying the variability and dynamics o...

journal_title：Nature communications

authors： Xu Z,Fallet E,Paoletti C,Fehrmann S,Charvin G,Teixeira MT

更新日期：2015-07-09 00:00:00

abstract：:The downstream consequences of inflammation in the adult mammalian heart are formation of a non-functional scar, pathological remodelling and heart failure. In zebrafish, hydrogen peroxide released from a wound is the initial instructive chemotactic cue for the infiltration of inflammatory cells, however, the identity...

journal_title：Nature communications

authors： Evans MA,Smart N,Dubé KN,Bollini S,Clark JE,Evans HG,Taams LS,Richardson R,Lévesque M,Martin P,Mills K,Riegler J,Price AN,Lythgoe MF,Riley PR

更新日期：2013-01-01 00:00:00

abstract：:The fossil record of crocodylians and their relatives (pseudosuchians) reveals a rich evolutionary history, prompting questions about causes of long-term decline to their present-day low biodiversity. We analyse climatic drivers of subsampled pseudosuchian biodiversity over their 250 million year history, using a comp...

journal_title：Nature communications

authors： Mannion PD,Benson RBJ,Carrano MT,Tennant JP,Judd J,Butler RJ

更新日期：2015-09-24 00:00:00

abstract：:Engineering catalytic sites at the atomic level provides an opportunity to understand the catalyst's active sites, which is vital to the development of improved catalysts. Here we show a reliable and tunable polyoxometalate template-based synthetic strategy to atomically engineer metal doping sites onto metallic 1T-Mo...

journal_title：Nature communications

authors： Huang Y,Sun Y,Zheng X,Aoki T,Pattengale B,Huang J,He X,Bian W,Younan S,Williams N,Hu J,Ge J,Pu N,Yan X,Pan X,Zhang L,Wei Y,Gu J

更新日期：2019-02-28 00:00:00

abstract：:Nanostructured metasurfaces offer unique capabilities for subwavelength control of optical waves. Based on this potential, a large number of metasurfaces have been proposed recently as alternatives to standard optical elements. In most cases, however, these elements suffer from large chromatic aberrations, thus limiti...

journal_title：Nature communications

authors： Avayu O,Almeida E,Prior Y,Ellenbogen T

更新日期：2017-04-05 00:00:00

abstract：:The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we add...

journal_title：Nature communications

authors： Fumagalli A,Heuninck J,Pizzoccaro A,Moutin E,Koenen J,Séveno M,Durroux T,Junier MP,Schlecht-Louf G,Bachelerie F,Schütz D,Stumm R,Smit MJ,Guérineau NC,Chaumont-Dubel S,Marin P

更新日期：2020-09-25 00:00:00

abstract：:In the evolutionary arms race between microbes, their parasites, and their neighbours, the capacity for rapid protein diversification is a potent weapon. Diversity-generating retroelements (DGRs) use mutagenic reverse transcription and retrohoming to generate myriad variants of a target gene. Originally discovered in ...

journal_title：Nature communications

authors： Paul BG,Bagby SC,Czornyj E,Arambula D,Handa S,Sczyrba A,Ghosh P,Miller JF,Valentine DL

更新日期：2015-03-23 00:00:00

abstract：:The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tum...

journal_title：Nature communications

authors： Woodcock DJ,Riabchenko E,Taavitsainen S,Kankainen M,Gundem G,Brewer DS,Ellonen P,Lepistö M,Golubeva YA,Warner AC,Tolonen T,Jasu J,Isaacs WB,Emmert-Buck MR,Nykter M,Visakorpi T,Bova GS,Wedge DC

更新日期：2020-10-08 00:00:00

abstract：:Arctic warming can influence tundra ecosystem function with consequences for climate feedbacks, wildlife and human communities. Yet ecological change across the Arctic tundra biome remains poorly quantified due to field measurement limitations and reliance on coarse-resolution satellite data. Here, we assess decadal c...

journal_title：Nature communications

authors： Berner LT,Massey R,Jantz P,Forbes BC,Macias-Fauria M,Myers-Smith I,Kumpula T,Gauthier G,Andreu-Hayles L,Gaglioti BV,Burns P,Zetterberg P,D'Arrigo R,Goetz SJ

更新日期：2020-09-22 00:00:00

abstract：:Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in dissecting the circuit mechanisms of itch at both the spinal and...

journal_title：Nature communications

authors： Chen XJ,Sun YG

更新日期：2020-06-16 00:00:00

abstract：:Alkali metal vapors enable access to single electron systems, suitable for demonstrating fundamental light-matter interactions and promising for quantum logic operations, storage and sensing. However, progress is hampered by the need for robust and repeatable control over the atomic vapor density and over the associat...

journal_title：Nature communications

authors： Rusimova KR,Slavov D,Pradaux-Caggiano F,Collins JT,Gordeev SN,Carbery DR,Wadsworth WJ,Mosley PJ,Valev VK

更新日期：2019-05-24 00:00:00

abstract：:Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low-transmission and post-elimination settings. Anal...

journal_title：Nature communications

authors： Pinsent A,Solomon AW,Bailey RL,Bid R,Cama A,Dean D,Goodhew B,Gwyn SE,Jack KR,Kandel RP,Kama M,Massae P,Macleod C,Mabey DCW,Migchelsen S,Müller A,Sandi F,Sokana O,Taoaba R,Tekeraoi R,Martin DL,White MT

更新日期：2018-12-21 00:00:00

abstract：:Many porous materials are damaged by pressure exerted by salt crystals growing in their pores. This is a serious issue in conservation science, geomorphology, geotechnical engineering and concrete materials science. In all cases, a central question is whether crystallization pressure will cause damage. Here we present...

journal_title：Nature communications

authors： Flatt RJ,Caruso F,Sanchez AM,Scherer GW

更新日期：2014-09-11 00:00:00

abstract：:Choroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal detachment. Here we develop nanoparticles (NP-[CPP]) that can be administered ...

journal_title：Nature communications

authors： Wang Y,Liu CH,Ji T,Mehta M,Wang W,Marino E,Chen J,Kohane DS

更新日期：2019-02-18 00:00:00

abstract：:The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation seq...

journal_title：Nature communications

authors： Elhaik E,Tatarinova T,Chebotarev D,Piras IS,Maria Calò C,De Montis A,Atzori M,Marini M,Tofanelli S,Francalacci P,Pagani L,Tyler-Smith C,Xue Y,Cucca F,Schurr TG,Gaieski JB,Melendez C,Vilar MG,Owings AC,Gómez R,Fuji

更新日期：2014-04-29 00:00:00

abstract：:TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contrast to its closest s...

journal_title：Nature communications

authors： Demircioglu FE,Zheng W,McQuown AJ,Maier NK,Watson N,Cheeseman IM,Denic V,Egelman EH,Schwartz TU

更新日期：2019-07-22 00:00:00

abstract：:Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...

journal_title：Nature communications

authors： Paldy E,Simonetti M,Worzfeld T,Bali KK,Vicuña L,Offermanns S,Kuner R

更新日期：2017-08-02 00:00:00

abstract：:Central spin decoherence caused by nuclear spin baths is often a critical issue in various quantum computing schemes, and it has also been used for sensing single-nuclear spins. Recent theoretical studies suggest that central spin decoherence can act as a probe of many-body physics in spin baths; however, identificati...

journal_title：Nature communications

authors： Ma WL,Wolfowicz G,Zhao N,Li SS,Morton JJ,Liu RB

更新日期：2014-09-10 00:00:00