Abstract：
:Enterobacteria, especially Escherichia coli, are abundant in patients with inflammatory bowel disease or colorectal cancer (CRC). However, it is unclear whether cancer is promoted by inflammation-induced expansion of E. coli and/or changes in expression of specific microbial genes. Here we use longitudinal (2, 12 and 20 weeks) 16S rRNA sequencing of luminal microbiota from ex-germ-free mice to show that inflamed Il10(-/-) mice maintain a higher abundance of Enterobacteriaceae than healthy wild-type mice. Experiments with mono-colonized Il10(-/-) mice reveal that host inflammation is necessary for E. coli cancer-promoting activity. RNA-sequence analysis indicates significant changes in E. coli gene catalogue in Il10(-/-) mice, with changes mostly driven by adaptation to the intestinal environment. Expression of specific genes present in the tumour-promoting E. coli pks island are modulated by inflammation/CRC development. Thus, progression of inflammation in Il10(-/-) mice supports Enterobacteriaceae and alters a small subset of microbial genes important for tumour development.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Arthur JC,Gharaibeh RZ,Mühlbauer M,Perez-Chanona E,Uronis JM,McCafferty J,Fodor AA,Jobin Cdoi
10.1038/ncomms5724subject
Has Abstractpub_date
2014-09-03 00:00:00pages
4724issn
2041-1723pii
ncomms5724journal_volume
5pub_type
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