Abstract:
:Τhe morphology, physiology and immunology, of solid tumors exhibit spatial heterogeneity which complicates our understanding of cancer progression and therapy response. Understanding spatial heterogeneity necessitates high resolution in vivo imaging of anatomical and pathophysiological tumor information. We introduce Rhodobacter as bacterial reporter for multispectral optoacoustic (photoacoustic) tomography (MSOT). We show that endogenous bacteriochlorophyll a in Rhodobacter gives rise to strong optoacoustic signals >800 nm away from interfering endogenous absorbers. Importantly, our results suggest that changes in the spectral signature of Rhodobacter which depend on macrophage activity inside the tumor can be used to reveal heterogeneity of the tumor microenvironment. Employing non-invasive high resolution MSOT in longitudinal studies we show spatiotemporal changes of Rhodobacter spectral profiles in mice bearing 4T1 and CT26.WT tumor models. Accessibility of Rhodobacter to genetic modification and thus to sensory and therapeutic functions suggests potential for a theranostic platform organism.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Peters L,Weidenfeld I,Klemm U,Loeschcke A,Weihmann R,Jaeger KE,Drepper T,Ntziachristos V,Stiel ACdoi
10.1038/s41467-019-09081-5subject
Has Abstractpub_date
2019-03-13 00:00:00pages
1191issue
1issn
2041-1723pii
10.1038/s41467-019-09081-5journal_volume
10pub_type
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