Chemo-mechanics of salt damage in stone.

abstract：:The gravitational collapse of eruption columns generates ground-hugging pyroclastic density currents (PDCs) with highly variable temperatures, high enough to be a threat for communities surrounding volcanoes. The reasons for such great temperature variability are debated in terms of eruptive versus transport and empla...

journal_title：Nature communications

authors： Trolese M,Cerminara M,Esposti Ongaro T,Giordano G

更新日期：2019-06-06 00:00:00

abstract：:The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to directly explore this mechanism in Plasmodium falciparum. We use an alkyne-tagged artemisinin analogue coupled with biotin to...

journal_title：Nature communications

authors： Wang J,Zhang CJ,Chia WN,Loh CC,Li Z,Lee YM,He Y,Yuan LX,Lim TK,Liu M,Liew CX,Lee YQ,Zhang J,Lu N,Lim CT,Hua ZC,Liu B,Shen HM,Tan KS,Lin Q

更新日期：2015-12-22 00:00:00

abstract：:Machines that simultaneously process and store multistate data at one and the same location can provide a new class of fast, powerful and efficient general-purpose computers. We demonstrate the central element of an all-optical calculator, a photonic abacus, which provides multistate compute-and-store operation by int...

journal_title：Nature communications

authors： Feldmann J,Stegmaier M,Gruhler N,Ríos C,Bhaskaran H,Wright CD,Pernice WHP

更新日期：2017-11-02 00:00:00

abstract：:Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate...

journal_title：Nature communications

authors： Kuzyk A,Yang Y,Duan X,Stoll S,Govorov AO,Sugiyama H,Endo M,Liu N

更新日期：2016-02-02 00:00:00

abstract：:Disordered mechanical systems, when strongly deformed, have complex configuration spaces with multiple stable states and pathways connecting them. The topology of such pathways determines which states are smoothly accessible from any part of configuration space. Controlling this topology would allow us to limit access...

journal_title：Nature communications

authors： Stern M,Jayaram V,Murugan A

更新日期：2018-10-16 00:00:00

abstract：:Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...

journal_title：Nature communications

authors： Astumian RD

更新日期：2019-08-23 00:00:00

abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

journal_title：Nature communications

authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

更新日期：2021-01-28 00:00:00

abstract：:Mitochondria and peroxisomes proliferate by division. During division, a part of their membrane is pinched off by constriction of the ring-shaped mitochondrial division (MD) and peroxisome-dividing (POD) machinery. This constriction is mediated by a dynamin-like GTPase Dnm1 that requires a large amount of GTP as an en...

journal_title：Nature communications

authors： Imoto Y,Abe Y,Honsho M,Okumoto K,Ohnuma M,Kuroiwa H,Kuroiwa T,Fujiki Y

更新日期：2018-11-06 00:00:00

abstract：:How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is unce...

journal_title：Nature communications

authors： Kim D,Chen R,Sheu M,Kim N,Kim S,Islam N,Wier EM,Wang G,Li A,Park A,Son W,Evans B,Yu V,Prizmic VP,Oh E,Wang Z,Yu J,Huang W,Archer NK,Hu Z,Clemetson N,Nelson AM,Chien A,Okoye GA,Miller LS,Ghiaur G,Kang S

更新日期：2019-06-26 00:00:00

abstract：:The relationships of passerines (such as the well-studied zebra finch) with non-passerine birds is one of the great enigmas of avian phylogenetic research, because decades of extensive morphological and molecular studies yielded highly inconsistent results between and within data sets. Here we show the first applicati...

journal_title：Nature communications

authors： Suh A,Paus M,Kiefmann M,Churakov G,Franke FA,Brosius J,Kriegs JO,Schmitz J

更新日期：2011-08-23 00:00:00

abstract：:Real-time imaging of moving organs and tissues at microscopic resolutions represents a major challenge in studying the complex biology of live animals. Here we present a technique based on a novel stabilizer setup combined with a gating acquisition algorithm for the imaging of a beating murine heart at the single-cell...

journal_title：Nature communications

authors： Lee S,Vinegoni C,Feruglio PF,Fexon L,Gorbatov R,Pivoravov M,Sbarbati A,Nahrendorf M,Weissleder R

更新日期：2012-01-01 00:00:00

abstract：:Lipids and amphiphilic block copolymers spontaneously self-assemble in water to form a plethora of micelles and vesicles. They are typically fluidic in nature and often mechanically weak for applications such as drug delivery and gene therapeutics. Mechanical properties of polymeric materials could be improved by form...

journal_title：Nature communications

authors： Wang W,Qi H,Zhou T,Mei S,Han L,Higuchi T,Jinnai H,Li CY

更新日期：2016-02-03 00:00:00

abstract：:During centriole duplication, a single daughter centriole is formed next to the mother centriole. The molecular mechanism that determines a single duplication site remains a long-standing question. Here, we show that intrinsic self-organization of Plk4 is implicated in symmetry breaking in the process of centriole dup...

journal_title：Nature communications

authors： Yamamoto S,Kitagawa D

更新日期：2019-04-18 00:00:00

abstract：:Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extrace...

journal_title：Nature communications

authors： Bradbury EJ,Burnside ER

更新日期：2019-08-28 00:00:00

abstract：:Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive assays for assessing transcription factor activity are lacking. Here we develop and validate a minimally invasive method for assessing TF activity based on cell-free DNA sequencing and nucleosome footprint analysis. W...

journal_title：Nature communications

authors： Ulz P,Perakis S,Zhou Q,Moser T,Belic J,Lazzeri I,Wölfler A,Zebisch A,Gerger A,Pristauz G,Petru E,White B,Roberts CES,John JS,Schimek MG,Geigl JB,Bauernhofer T,Sill H,Bock C,Heitzer E,Speicher MR

更新日期：2019-10-11 00:00:00

abstract：:Regional differences in health-related phenotypes have been detected between and within countries. In Scotland, regions differ for a variety of health-related traits and display differences in mean lifespan of up to 7.5 years. Both genetics and lifestyle differences are potential causes of this variation. Using data o...

journal_title：Nature communications

authors： Amador C,Xia C,Nagy R,Campbell A,Porteous D,Smith BH,Hastie N,Vitart V,Hayward C,Navarro P,Haley CS

更新日期：2017-10-06 00:00:00

abstract：:Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. Here, we characterize a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes. SVIP is essential for l...

journal_title：Nature communications

authors： Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW

更新日期：2021-01-21 00:00:00

abstract：:Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather th...

journal_title：Nature communications

authors： Yang TT,Chong WM,Wang WJ,Mazo G,Tanos B,Chen Z,Tran TMN,Chen YD,Weng RR,Huang CE,Jane WN,Tsou MB,Liao JC

更新日期：2018-05-22 00:00:00

abstract：:The insulator-metal transition (IMT) of vanadium dioxide (VO2) has remained a long-standing challenge in correlated electron physics since its discovery five decades ago. Most interpretations of experimental observations have implicitly assumed a homogeneous material response. Here we reveal inhomogeneous behaviour of...

journal_title：Nature communications

authors： O'Callahan BT,Jones AC,Hyung Park J,Cobden DH,Atkin JM,Raschke MB

更新日期：2015-04-21 00:00:00

abstract：:The liquid and glass states of metal-organic frameworks (MOFs) have recently become of interest due to the potential for liquid-phase separations and ion transport, alongside the fundamental nature of the latter as a new, fourth category of melt-quenched glass. Here we show that the MOF liquid state can be blended wit...

journal_title：Nature communications

authors： Longley L,Collins SM,Zhou C,Smales GJ,Norman SE,Brownbill NJ,Ashling CW,Chater PA,Tovey R,Schönlieb CB,Headen TF,Terrill NJ,Yue Y,Smith AJ,Blanc F,Keen DA,Midgley PA,Bennett TD

更新日期：2018-06-15 00:00:00

abstract：:Continuous cycles of nucleocytoplasmic transport require disassembly of transport receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all eukaryotes depends on soluble RanGAP and RanBP1. In vertebrates, a significant fraction of RanGAP1 stably interacts with the nucleoporin RanBP2 at a bindin...

journal_title：Nature communications

authors： Ritterhoff T,Das H,Hofhaus G,Schröder RR,Flotho A,Melchior F

更新日期：2016-05-10 00:00:00

abstract：:The outcome of molecule-surface collisions can be modified by pre-aligning the molecule; however, experiments accomplishing this are rare because of the difficulty of preparing molecules in aligned quantum states. Here we present a general solution to this problem based on magnetic manipulation of the rotational magne...

journal_title：Nature communications

authors： Godsi O,Corem G,Alkoby Y,Cantin JT,Krems RV,Somers MF,Meyer J,Kroes GJ,Maniv T,Alexandrowicz G

更新日期：2017-05-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2020-01-14 00:00:00

abstract：:Two-dimensional materials provide extraordinary opportunities for exploring phenomena arising in atomically thin crystals. Beginning with the first isolation of graphene, mechanical exfoliation has been a key to provide high-quality two-dimensional materials, but despite improvements it is still limited in yield, late...

journal_title：Nature communications

authors： Huang Y,Pan YH,Yang R,Bao LH,Meng L,Luo HL,Cai YQ,Liu GD,Zhao WJ,Zhou Z,Wu LM,Zhu ZL,Huang M,Liu LW,Liu L,Cheng P,Wu KH,Tian SB,Gu CZ,Shi YG,Guo YF,Cheng ZG,Hu JP,Zhao L,Yang GH,Sutter E,Sutter P,Wan

更新日期：2020-05-15 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15587. ...

journal_title：Nature communications

authors： Yu T,Zhou YJ,Wenning L,Liu Q,Krivoruchko A,Siewers V,Nielsen J,David F

更新日期：2018-07-13 00:00:00

abstract：:The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and cyber-physical system integrations. Novel applications of 'bio-informational' engineering will arise in environmental monitorin...

journal_title：Nature communications

authors： Dixon TA,Williams TC,Pretorius IS

更新日期：2021-01-15 00:00:00

abstract：:The primary productivity of the Southern Ocean ecosystem is limited by iron availability. Away from benthic and aeolian sources, iron reaches phytoplankton primarily when iron-rich subsurface waters enter the euphotic zone. Here, eddy-resolving physical/biogeochemical simulations of a seasonally-forced, open-Southern-...

journal_title：Nature communications

authors： Uchida T,Balwada D,P Abernathey R,A McKinley G,K Smith S,Lévy M

更新日期：2020-02-28 00:00:00

abstract：:Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified associa...

journal_title：Nature communications

authors： Arnold M,Nho K,Kueider-Paisley A,Massaro T,Huynh K,Brauner B,MahmoudianDehkordi S,Louie G,Moseley MA,Thompson JW,John-Williams LS,Tenenbaum JD,Blach C,Chang R,Brinton RD,Baillie R,Han X,Trojanowski JQ,Shaw LM,Martin

更新日期：2020-03-02 00:00:00

abstract：:Tradeoffs affect resource allocation during development and result in fitness consequences that drive the evolution of life history strategies. Yet despite their importance, we know little about the mechanisms underlying life history tradeoffs. Many species of Colias butterflies exhibit an alternative life history str...

journal_title：Nature communications

authors： Woronik A,Tunström K,Perry MW,Neethiraj R,Stefanescu C,Celorio-Mancera MP,Brattström O,Hill J,Lehmann P,Käkelä R,Wheat CW

更新日期：2019-12-17 00:00:00

abstract：:The host-guest recognition between two macrocycles to form hierarchical non-intertwined ring-in-ring assemblies remains an interesting and challenging target in noncovalent synthesis. Herein, we report the design and characterization of a box-in-box assembly on the basis of host-guest radical-pairing interactions betw...

journal_title：Nature communications

authors： Cai K,Lipke MC,Liu Z,Nelson J,Cheng T,Shi Y,Cheng C,Shen D,Han JM,Vemuri S,Feng Y,Stern CL,Goddard WA 3rd,Wasielewski MR,Stoddart JF

更新日期：2018-12-10 00:00:00