Self-organization of Plk4 regulates symmetry breaking in centriole duplication.

abstract：:Energy affects every single individual and entity in the world. Therefore, it is crucial to precisely quantify the "price of energy" and study how it evolves through time, through major political and social events, and through changes in energy and monetary policies. Here, we develop a predictive framework, an index t...

journal_title：Nature communications

authors： Baratsas SG,Niziolek AM,Onel O,Matthews LR,Floudas CA,Hallermann DR,Sorescu SM,Pistikopoulos EN

更新日期：2021-01-04 00:00:00

abstract：:The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major component...

journal_title：Nature communications

authors： Haller F,Bieg M,Will R,Körner C,Weichenhan D,Bott A,Ishaque N,Lutsik P,Moskalev EA,Mueller SK,Bähr M,Woerner A,Kaiser B,Scherl C,Haderlein M,Kleinheinz K,Fietkau R,Iro H,Eils R,Hartmann A,Plass C,Wiemann S,Aga

更新日期：2019-01-21 00:00:00

abstract：:Striated muscle contraction is regulated by the translocation of troponin-tropomyosin strands over the thin filament surface. Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts between actin and tropomyosin, which position tropomyosin such that it impedes actomyosin association...

journal_title：Nature communications

authors： Viswanathan MC,Schmidt W,Franz P,Rynkiewicz MJ,Newhard CS,Madan A,Lehman W,Swank DM,Preller M,Cammarato A

更新日期：2020-05-15 00:00:00

abstract：:Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...

journal_title：Nature communications

authors： Förg M,Colombier L,Patel RK,Lindlau J,Mohite AD,Yamaguchi H,Glazov MM,Hunger D,Högele A

更新日期：2019-08-16 00:00:00

abstract：:Increasing evidence suggests that neural population responses have their own internal drive, or dynamics, that describe how the neural population evolves through time. An important prediction of neural dynamical models is that previously observed neural activity is informative of noisy yet-to-be-observed activity on s...

journal_title：Nature communications

authors： Kao JC,Nuyujukian P,Ryu SI,Churchland MM,Cunningham JP,Shenoy KV

更新日期：2015-07-29 00:00:00

abstract：:Despite the maximized metal dispersion offered by single-atom catalysts, further improvement of intrinsic activity can be hindered by the lack of neighboring metal atoms in these systems. Here we report the use of isolated Pt1 atoms on ceria as "seeds" to develop a Pt-O-Pt ensemble, which is well-represented by a Pt8O...

journal_title：Nature communications

authors： Wang H,Liu JX,Allard LF,Lee S,Liu J,Li H,Wang J,Wang J,Oh SH,Li W,Flytzani-Stephanopoulos M,Shen M,Goldsmith BR,Yang M

更新日期：2019-08-23 00:00:00

abstract：:Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies all...

journal_title：Nature communications

authors： Xomalis A,Demirtzioglou I,Plum E,Jung Y,Nalla V,Lacava C,MacDonald KF,Petropoulos P,Richardson DJ,Zheludev NI

更新日期：2018-01-12 00:00:00

abstract：:The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at ...

journal_title：Nature communications

authors： Porubsky D,Garg S,Sanders AD,Korbel JO,Guryev V,Lansdorp PM,Marschall T

更新日期：2017-11-03 00:00:00

abstract：:The polypterids (bichirs and ropefish) are extant basal actinopterygian (ray-finned) fishes that breathe air and share similarities with extant lobe-finned sarcopterygians (lungfishes and tetrapods) in lung structure. They are also similar to some fossil sarcopterygians, including stem tetrapods, in having large paire...

journal_title：Nature communications

authors： Graham JB,Wegner NC,Miller LA,Jew CJ,Lai NC,Berquist RM,Frank LR,Long JA

更新日期：2014-01-01 00:00:00

abstract：:Recent progress in the understanding of percolation theory points to cation-disordered lithium-excess transition metal oxides as high-capacity lithium-ion cathode materials. Nevertheless, the oxygen redox processes required for these materials to deliver high capacity can trigger oxygen loss, which leads to the format...

journal_title：Nature communications

authors： Lee J,Papp JK,Clément RJ,Sallis S,Kwon DH,Shi T,Yang W,McCloskey BD,Ceder G

更新日期：2017-10-17 00:00:00

abstract：:Anthropogenic methane emissions from China are likely greater than in any other country in the world. The largest fraction of China's anthropogenic emissions is attributable to coal mining, but these emissions may be changing; China enacted a suite of regulations for coal mine methane (CMM) drainage and utilization th...

journal_title：Nature communications

authors： Miller SM,Michalak AM,Detmers RG,Hasekamp OP,Bruhwiler LMP,Schwietzke S

更新日期：2019-01-29 00:00:00

abstract：:Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibito...

journal_title：Nature communications

authors： Liu Q,Deng S,Liu B,Tao Y,Ai H,Liu J,Zhang Y,Zhao Y,Xu M

更新日期：2020-01-24 00:00:00

abstract：:The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

journal_title：Nature communications

authors： Van de Water K,Sterckx YG,Volkov AN

更新日期：2015-05-06 00:00:00

abstract：:Nanostructured silicon has generated a lot of interest in the past decades as a key material for silicon-based photonics. The low absorption coefficient makes silicon nanocrystals attractive as an active medium in waveguide structures, and their third-order nonlinear optical properties are crucial for the development ...

journal_title：Nature communications

authors： Sirleto L,Ferrara MA,Nikitin T,Novikov S,Khriachtchev L

更新日期：2012-01-01 00:00:00

abstract：:Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ioni...

journal_title：Nature communications

authors： Corde S,Adli E,Allen JM,An W,Clarke CI,Clausse B,Clayton CE,Delahaye JP,Frederico J,Gessner S,Green SZ,Hogan MJ,Joshi C,Litos M,Lu W,Marsh KA,Mori WB,Vafaei-Najafabadi N,Walz D,Yakimenko V

更新日期：2016-06-17 00:00:00

abstract：:Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...

journal_title：Nature communications

authors： Wu Y,Subotnik JE

更新日期：2021-01-29 00:00:00

abstract：:Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equivalent ...

journal_title：Nature communications

authors： Baudoin M,Thomas JL,Sahely RA,Gerbedoen JC,Gong Z,Sivery A,Matar OB,Smagin N,Favreau P,Vlandas A

更新日期：2020-08-25 00:00:00

abstract：:Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cell...

journal_title：Nature communications

authors： Cerro-Herreros E,Sabater-Arcis M,Fernandez-Costa JM,Moreno N,Perez-Alonso M,Llamusi B,Artero R

更新日期：2018-06-26 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00

abstract：:The insulator-metal transition (IMT) of vanadium dioxide (VO2) has remained a long-standing challenge in correlated electron physics since its discovery five decades ago. Most interpretations of experimental observations have implicitly assumed a homogeneous material response. Here we reveal inhomogeneous behaviour of...

journal_title：Nature communications

authors： O'Callahan BT,Jones AC,Hyung Park J,Cobden DH,Atkin JM,Raschke MB

更新日期：2015-04-21 00:00:00

abstract：:Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations cause atrophy of the optic nerve leading to blindness. Here, we show that OPA1 has an important role in the innate immune system. Using conditional ...

journal_title：Nature communications

authors： Amini P,Stojkov D,Felser A,Jackson CB,Courage C,Schaller A,Gelman L,Soriano ME,Nuoffer JM,Scorrano L,Benarafa C,Yousefi S,Simon HU

更新日期：2018-07-27 00:00:00

abstract：:Many microorganisms, with phytoplankton and zooplankton as prominent examples, display phototactic behaviour, that is, the ability to perform directed motion within a light gradient. Here we experimentally demonstrate that sensing of light gradients can also be achieved in a system of synthetic photo-activated micropa...

journal_title：Nature communications

authors： Lozano C,Ten Hagen B,Löwen H,Bechinger C

更新日期：2016-09-30 00:00:00

abstract：:CRISPR/Cas9 technology offers novel approaches for the development of new therapies for many unmet clinical needs, including a significant number of inherited monogenic diseases. However, in vivo correction of disease-causing genes is still inefficient, especially for those diseases without selective advantage for cor...

journal_title：Nature communications

authors： Zabaleta N,Barberia M,Martin-Higueras C,Zapata-Linares N,Betancor I,Rodriguez S,Martinez-Turrillas R,Torella L,Vales A,Olagüe C,Vilas-Zornoza A,Castro-Labrador L,Lara-Astiaso D,Prosper F,Salido E,Gonzalez-Aseguinolaza G,R

更新日期：2018-12-21 00:00:00

abstract：:Transition metal reagents and catalysts are generally effective to cleave all three bonds (one σ and two π) in a triple bond despite its high bonding energy. Recently, chemistry of single-bond cleavage by using main-group element compounds is rapidly being developed in the absence of transition metals. However, the cl...

journal_title：Nature communications

authors： Asakawa H,Lee KH,Lin Z,Yamashita M

更新日期：2014-06-26 00:00:00

abstract：:The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system for motor coordination. Here we describe a novel mechanism by which ghrelin enhances firing of nigral dopaminergic neurons by i...

journal_title：Nature communications

authors： Shi L,Bian X,Qu Z,Ma Z,Zhou Y,Wang K,Jiang H,Xie J

更新日期：2013-01-01 00:00:00

abstract：:Plasmonics on metal-dielectric interfaces was widely seen as the main route for miniaturization of components and interconnect of photonic circuits. However recently, ultra-confined surface phonon-polaritonics in high-index chalcogenide films of nanometric thickness has emerged as an important alternative to plasmonic...

journal_title：Nature communications

authors： Dubrovkin AM,Qiang B,Salim T,Nam D,Zheludev NI,Wang QJ

更新日期：2020-04-20 00:00:00

abstract：:Exposure to extreme events is a major concern in coastal regions where growing human populations and stressed natural ecosystems are at significant risk to such phenomena. However, the complex sequence of processes that transform an event from notable to extreme can be challenging to identify and hence, limit forecast...

journal_title：Nature communications

authors： Dzwonkowski B,Coogan J,Fournier S,Lockridge G,Park K,Lee T

更新日期：2020-09-22 00:00:00

abstract：:FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser552, and promotes its...

journal_title：Nature communications

authors： Yang F,Xu J,Li H,Tan M,Xiong X,Sun Y

更新日期：2019-03-27 00:00:00

abstract：:T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram an intact TCR co...

journal_title：Nature communications

authors： Baeuerle PA,Ding J,Patel E,Thorausch N,Horton H,Gierut J,Scarfo I,Choudhary R,Kiner O,Krishnamurthy J,Le B,Morath A,Baldeviano GC,Quinn J,Tavares P,Wei Q,Weiler S,Maus MV,Getts D,Schamel WW,Hofmeister R

更新日期：2019-05-07 00:00:00

abstract：:The size of the membrane-bound nucleus scales with cell size in a wide range of cell types but the mechanisms determining overall nuclear size remain largely unknown. Here we investigate the role of fission yeast inner nuclear membrane proteins in determining nuclear size, and propose that the Lap2-Emerin-Man1 domain ...

journal_title：Nature communications

authors： Kume K,Cantwell H,Burrell A,Nurse P

更新日期：2019-04-23 00:00:00