Abstract:
:Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cells. We thus identify miR-23b and miR-218, and confirm that they downregulate MBNL proteins in this cell line. Antagonists of miR-23b and miR-218 miRNAs enhance MBNL protein levels and rescue pathogenic missplicing events in DM1 myoblasts. Systemic delivery of these "antagomiRs" similarly boost MBNL expression and improve DM1-like phenotypes, including splicing alterations, histopathology, and myotonia in the HSALR DM1 model mice. These mammalian data provide evidence for therapeutic blocking of the miRNAs that control Muscleblind-like protein expression in myotonic dystrophy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Cerro-Herreros E,Sabater-Arcis M,Fernandez-Costa JM,Moreno N,Perez-Alonso M,Llamusi B,Artero Rdoi
10.1038/s41467-018-04892-4subject
Has Abstractpub_date
2018-06-26 00:00:00pages
2482issue
1issn
2041-1723pii
10.1038/s41467-018-04892-4journal_volume
9pub_type
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