Aqueous multiphoton lithography with multifunctional silk-centred bio-resists.

abstract：:Neurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form of axonal remodelling alters brain functional structure remains unclear. To understand how collateral sprouting proceeds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibre...

journal_title：Nature communications

authors： Dhar M,Brenner JM,Sakimura K,Kano M,Nishiyama H

更新日期：2016-09-21 00:00:00

abstract：:The degraded, misfolded C terminus of TAR DNA-binding protein-43 is associated with a wide spectrum of neurodegenerative diseases, particularly frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. However, the precise mechanism of pathological cleavage of the TAR DNA-...

journal_title：Nature communications

authors： Wang IF,Chang HY,Hou SC,Liou GG,Way TD,James Shen CK

更新日期：2012-04-03 00:00:00

abstract：:A subset of transcription factors classified as neural crest 'specifiers' are also core epithelial-mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The bHLH factor Twist is among the least well studied of these factors. Here we demonstrate that Twist is required for crania...

journal_title：Nature communications

authors： Lander R,Nasr T,Ochoa SD,Nordin K,Prasad MS,Labonne C

更新日期：2013-01-01 00:00:00

abstract：:Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be ...

journal_title：Nature communications

authors： Zalesskiy SS,Kitson PJ,Frei P,Bubliauskas A,Cronin L

更新日期：2019-12-02 00:00:00

abstract：:In two-dimensional interfacial assemblies, there is an interplay between molecular ordering and interface geometry, which determines the final morphology and order of entire systems. Here we present the interfacial phenomenon of spontaneous facet formation in a water droplet driven by designed peptide assembly. The id...

journal_title：Nature communications

authors： Jang HS,Lee JH,Park YS,Kim YO,Park J,Yang TY,Jin K,Lee J,Park S,You JM,Jeong KW,Shin A,Oh IS,Kwon MK,Kim YI,Cho HH,Han HN,Kim Y,Chang YH,Paik SR,Nam KT,Lee YS

更新日期：2014-04-11 00:00:00

abstract：:A key question of theoretical ecology is which properties of ecosystems favour their stability and help maintaining biodiversity. This question recently reconsidered mutualistic systems, generating intense controversy about the role of mutualistic interactions and their network architecture. Here we show analytically ...

journal_title：Nature communications

authors： Pascual-García A,Bastolla U

更新日期：2017-02-24 00:00:00

abstract：:The ability to link soil microbial diversity to soil processes requires technologies that differentiate active microbes from extracellular DNA and dormant cells. Here, we use BONCAT (bioorthogonal non-canonical amino acid tagging) to measure translationally active cells in soils. We compare the active population of tw...

journal_title：Nature communications

authors： Couradeau E,Sasse J,Goudeau D,Nath N,Hazen TC,Bowen BP,Chakraborty R,Malmstrom RR,Northen TR

更新日期：2019-06-24 00:00:00

abstract：:Cyclophanes are a venerable class of macrocyclic and/or cage compounds that often feature high strain, unusual conformations and quite surprising properties, many of which are legendary in physical organic chemistry. However, the discovery of new, diverse cyclophanes and derivatives has been hindered by syntheses that...

journal_title：Nature communications

authors： Collins MS,Carnes ME,Nell BP,Zakharov LN,Johnson DW

更新日期：2016-04-04 00:00:00

abstract：:Perovskite quantum-dot-based light-emitting diodes (QLEDs) possess the features of wide gamut and real color expression, which have been considered as candidates for high-quality lightings and displays. However, massive defects are prone to be reproduced during the quantum dot (QD) film assembly, which would sorely af...

journal_title：Nature communications

authors： Xu L,Li J,Cai B,Song J,Zhang F,Fang T,Zeng H

更新日期：2020-08-06 00:00:00

abstract：:Continuous cycles of nucleocytoplasmic transport require disassembly of transport receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all eukaryotes depends on soluble RanGAP and RanBP1. In vertebrates, a significant fraction of RanGAP1 stably interacts with the nucleoporin RanBP2 at a bindin...

journal_title：Nature communications

authors： Ritterhoff T,Das H,Hofhaus G,Schröder RR,Flotho A,Melchior F

更新日期：2016-05-10 00:00:00

abstract：:Plant phytochromes are thought to transduce light signals by mediating the degradation of phytochrome-interacting transcription factors (PIFs) through the N-terminal photosensory module, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not participate in signaling. Here we show tha...

journal_title：Nature communications

authors： Qiu Y,Pasoreck EK,Reddy AK,Nagatani A,Ma W,Chory J,Chen M

更新日期：2017-12-04 00:00:00

abstract：:Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response is universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elong...

journal_title：Nature communications

authors： Xu S,Zhan M,Jiang C,He M,Yang L,Shen H,Huang S,Huang X,Lin R,Shi Y,Liu Q,Chen W,Mohan M,Wang J

更新日期：2019-12-02 00:00:00

abstract：:Many decisions are based on an internal model of the world. Yet, how such a model is constructed from experience and represented in memory remains unknown. We test the hypothesis that reward shapes memory for sequences of events by retroactively prioritizing memory for objects as a function of their distance from rewa...

journal_title：Nature communications

authors： Braun EK,Wimmer GE,Shohamy D

更新日期：2018-11-20 00:00:00

abstract：:Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates that ADLumin-1 can efficien...

journal_title：Nature communications

authors： Yang J,Yin W,Van R,Yin K,Wang P,Zheng C,Zhu B,Ran K,Zhang C,Kumar M,Shao Y,Ran C

更新日期：2020-08-13 00:00:00

abstract：:Astrocytes are implicated in modulation of neuronal excitability and synaptic function, but it remains unknown if these glial cells can directly control activities of motor circuits to influence complex behaviors in vivo. This study focused on the vital respiratory rhythm-generating circuits of the preBötzinger comple...

journal_title：Nature communications

authors： Sheikhbahaei S,Turovsky EA,Hosford PS,Hadjihambi A,Theparambil SM,Liu B,Marina N,Teschemacher AG,Kasparov S,Smith JC,Gourine AV

更新日期：2018-01-25 00:00:00

abstract：:Broomcorn millet (Panicum miliaceum L.) is the most water-efficient cereal and one of the earliest domesticated plants. Here we report its high-quality, chromosome-scale genome assembly using a combination of short-read sequencing, single-molecule real-time sequencing, Hi-C, and a high-density genetic map. Phylogeneti...

journal_title：Nature communications

authors： Zou C,Li L,Miki D,Li D,Tang Q,Xiao L,Rajput S,Deng P,Peng L,Jia W,Huang R,Zhang M,Sun Y,Hu J,Fu X,Schnable PS,Chang Y,Li F,Zhang H,Feng B,Zhu X,Liu R,Schnable JC,Zhu JK,Zhang H

更新日期：2019-01-25 00:00:00

abstract：:A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability an...

journal_title：Nature communications

authors： Guiziou S,Mayonove P,Bonnet J

更新日期：2019-01-28 00:00:00

abstract：:Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/r...

journal_title：Nature communications

authors： Siddiqi FH,Menzies FM,Lopez A,Stamatakou E,Karabiyik C,Ureshino R,Ricketts T,Jimenez-Sanchez M,Esteban MA,Lai L,Tortorella MD,Luo Z,Liu H,Metzakopian E,Fernandes HJR,Bassett A,Karran E,Miller BL,Fleming A,Rubinsztei

更新日期：2019-04-18 00:00:00

abstract：:Changes in cellular metabolism are associated with the activation of diverse immune subsets. These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate and function. An emerging concept is that nutrients are not equally available to all immune cell...

journal_title：Nature communications

authors： Kedia-Mehta N,Finlay DK

更新日期：2019-05-09 00:00:00

abstract：:MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...

journal_title：Nature communications

authors： Alivernini S,Kurowska-Stolarska M,Tolusso B,Benvenuto R,Elmesmari A,Canestri S,Petricca L,Mangoni A,Fedele AL,Di Mario C,Gigante MR,Gremese E,McInnes IB,Ferraccioli G

更新日期：2016-09-27 00:00:00

abstract：:The yeast Saccharomyces cerevisiae has been an essential component of human civilization because of its long global history of use in food and beverage fermentation. However, the diversity and evolutionary history of the domesticated populations of the yeast remain elusive. We show here that China/Far East Asia is lik...

journal_title：Nature communications

authors： Duan SF,Han PJ,Wang QM,Liu WQ,Shi JY,Li K,Zhang XL,Bai FY

更新日期：2018-07-12 00:00:00

abstract：:Gluconeogenesis is a fundamental metabolic process that allows organisms to make sugars from non-carbohydrate stores such as lipids and protein. In eukaryotes only one gluconeogenic route has been described from organic acid intermediates and this relies on the enzyme phosphoenolpyruvate carboxykinase (PCK). Here we s...

journal_title：Nature communications

authors： Eastmond PJ,Astley HM,Parsley K,Aubry S,Williams BP,Menard GN,Craddock CP,Nunes-Nesi A,Fernie AR,Hibberd JM

更新日期：2015-04-10 00:00:00

abstract：:Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...

journal_title：Nature communications

authors： Lu YJ,Li P,Shimono M,Corrion A,Higaki T,He SY,Day B

更新日期：2020-12-04 00:00:00

abstract：:Seeded propagation of amyloid-beta (Aβ) pathology is suggested to contribute to the progression of Alzheimer's disease. Local overproduction of aggregation-prone Aβ variants could explain the focal initiation of a seeding cascade that subsequently triggers widespread pathology. Several animal models support this seedi...

journal_title：Nature communications

authors： Sowade RF,Jahn TR

更新日期：2017-09-11 00:00:00

abstract：:At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic expression of the ...

journal_title：Nature communications

authors： Anton KA,Kajita M,Narumi R,Fujita Y,Tada M

更新日期：2018-11-08 00:00:00

abstract：:The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries. Here, we perform de novo assembly of three Japanese male genomes using ...

journal_title：Nature communications

authors： Takayama J,Tadaka S,Yano K,Katsuoka F,Gocho C,Funayama T,Makino S,Okamura Y,Kikuchi A,Sugimoto S,Kawashima J,Otsuki A,Sakurai-Yageta M,Yasuda J,Kure S,Kinoshita K,Yamamoto M,Tamiya G

更新日期：2021-01-11 00:00:00

abstract：:Phonons are the main source of relaxation in molecular nanomagnets, and different mechanisms have been proposed in order to explain the wealth of experimental findings. However, very limited experimental investigations on phonons in these systems have been performed so far, yielding no information about their dispersi...

journal_title：Nature communications

authors： Garlatti E,Tesi L,Lunghi A,Atzori M,Voneshen DJ,Santini P,Sanvito S,Guidi T,Sessoli R,Carretta S

更新日期：2020-04-09 00:00:00

abstract：:Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using gain-and-loss of f...

journal_title：Nature communications

authors： Wilson R,Espinosa-Diez C,Kanner N,Chatterjee N,Ruhl R,Hipfinger C,Advani SJ,Li J,Khan OF,Franovic A,Weis SM,Kumar S,Coussens LM,Anderson DG,Chen CC,Cheresh DA,Anand S

更新日期：2016-11-25 00:00:00

abstract：:Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar pla...

journal_title：Nature communications

authors： Slaughter BD,Unruh JR,Das A,Smith SE,Rubinstein B,Li R

更新日期：2013-01-01 00:00:00

abstract：:Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the current...

journal_title：Nature communications

authors： Petrone L,Kumar A,Sutanto CN,Patil NJ,Kannan S,Palaniappan A,Amini S,Zappone B,Verma C,Miserez A

更新日期：2015-10-28 00:00:00