Abstract:
:Changes in cellular metabolism are associated with the activation of diverse immune subsets. These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate and function. An emerging concept is that nutrients are not equally available to all immune cells, suggesting that the regulation of nutrient utility through competitive uptake and use is important for controlling immune responses. This review considers immune microenvironments where nutrients become limiting, the signalling alterations caused by insufficient nutrients, and the importance of nutrient availability in the regulation of immune responses.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kedia-Mehta N,Finlay DKdoi
10.1038/s41467-019-10015-4subject
Has Abstractpub_date
2019-05-09 00:00:00pages
2123issue
1issn
2041-1723pii
10.1038/s41467-019-10015-4journal_volume
10pub_type
杂志文章,评审abstract::Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15995-2
更新日期:2020-04-27 00:00:00
abstract::Single-crystal cathode materials for lithium-ion batteries have attracted increasing interest in providing greater capacity retention than their polycrystalline counterparts. However, after being cycled at high voltages, these single-crystal materials exhibit severe structural instability and capacity fade. Understand...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16824-2
更新日期:2020-06-16 00:00:00
abstract::Clustered regularly-interspaced palindromic repeats (CRISPR)-based genetic screens using single-guide-RNA (sgRNA) libraries have proven powerful to identify genetic regulators. Applying CRISPR screens to interrogate functional elements in noncoding regions requires generating sgRNA libraries that are densely covering,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11178
更新日期:2016-03-30 00:00:00
abstract::Many crystals, such as those of metals, can transform from one symmetry into another having lower free energy via a diffusionless transformation. Here we create binary colloidal crystals consisting of polymer microspheres, pulled together by DNA bridges, that induce specific, reversible attractions between two species...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2206
更新日期:2012-01-01 00:00:00
abstract::Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04910-5
更新日期:2018-07-17 00:00:00
abstract::The emerging monolayer transition metal dichalcogenides have provided an unprecedented material platform for miniaturized opto-electronic devices with integrated functionalities. Although excitonic light-matter interactions associated with their direct bandgaps have received tremendous research efforts, wavefront engi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20278-x
更新日期:2021-01-04 00:00:00
abstract::Perovskite solar cells present one of the most prominent photovoltaic technologies, yet their stability, scalability, and engineering at the molecular level remain challenging. We demonstrate a concept of multifunctional molecular modulation of scalable and operationally stable perovskite solar cells that exhibit exce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06709-w
更新日期:2018-10-26 00:00:00
abstract::Selector devices are indispensable components of large-scale nonvolatile memory and neuromorphic array systems. Besides the conventional silicon transistor, two-terminal ovonic threshold switching device with much higher scalability is currently the most industrially favored selector technology. However, current ovoni...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18382-z
更新日期:2020-09-15 00:00:00
abstract::Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14791
更新日期:2017-03-24 00:00:00
abstract::By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivity by SMR transporters is needed to identify the types of selective pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19820-8
更新日期:2020-11-27 00:00:00
abstract::Breaking time-reversal symmetry enables the realization of non-reciprocal devices, such as isolators and circulators, of fundamental importance in microwave and photonic communication systems. This effect is almost exclusively achieved today through magneto-optical phenomena, which are incompatible with integrated tec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3407
更新日期:2013-01-01 00:00:00
abstract::Many decisions are based on an internal model of the world. Yet, how such a model is constructed from experience and represented in memory remains unknown. We test the hypothesis that reward shapes memory for sequences of events by retroactively prioritizing memory for objects as a function of their distance from rewa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07280-0
更新日期:2018-11-20 00:00:00
abstract::The central phenomenon in the field of organic spintronics is the large magnetoresistance in thick organic spin valves. A prerequisite for understanding the magnetoresistance is a reliable description of the device resistance, or the I-V characteristics. Here I show that the observed I-V characteristics in the organic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5842
更新日期:2014-09-09 00:00:00
abstract::Controlling the structure of catalysts at the atomic level provides an opportunity to establish detailed understanding of the catalytic form-to-function and realize new, non-equilibrium catalytic structures. Here, advanced thin-film deposition is used to control the atomic structure of La2/3Sr1/3MnO3, a well-known cat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06503-8
更新日期:2018-10-02 00:00:00
abstract::Reversible acetylation of α-tubulin is an evolutionarily conserved modification in microtubule networks. Despite its prevalence, the physiological function and regulation of microtubule acetylation remain poorly understood. Here we report that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo exten...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4479
更新日期:2014-03-17 00:00:00
abstract::Ruddlesden-Popper halide perovskites are 2D solution-processed quantum wells with a general formula A2A'n-1M n X3n+1, where optoelectronic properties can be tuned by varying the perovskite layer thickness (n-value), and have recently emerged as efficient semiconductors with technologically relevant stability. However,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04659-x
更新日期:2018-06-08 00:00:00
abstract::The term tunnel electroresistance (TER) denotes a fast, non-volatile, reversible resistance switching triggered by voltage pulses in ferroelectric tunnel junctions. It is explained by subtle mechanisms connected to the voltage-induced reversal of the ferroelectric polarization. Here we demonstrate that effects functio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14379-w
更新日期:2020-01-31 00:00:00
abstract::The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary duct in proximit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17102-x
更新日期:2020-07-06 00:00:00
abstract::Trace elements diffuse negligible distances through the pristine crystal lattice in minerals: this is a fundamental assumption when using them to decipher geological processes. For example, the reliable use of the mineral zircon (ZrSiO4) as a U-Th-Pb geochronometer and trace element monitor requires minimal radiogenic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10490
更新日期:2016-02-12 00:00:00
abstract::Polarization-driven resistive switching in ferroelectric tunnel junctions (FTJs)--structures composed of two electrodes separated by an ultrathin ferroelectric barrier--offers new physics and materials functionalities, as well as exciting opportunities for the next generation of non-volatile memories and logic devices...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6518
更新日期:2014-11-24 00:00:00
abstract::Sunlight is the ultimate driver of biosynthesis but photochemical steps late in biosynthetic pathways are very rare. They appear to play a role in the formation of certain furanocembranoids isolated from Caribbean corals. One of these compounds, intricarene, has been suspected to arise from an intramolecular 1,3-dipol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6597
更新日期:2014-12-03 00:00:00
abstract::Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires phosphoinositide 3-kinase (PI3K), while that of small ones does not. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9623
更新日期:2015-10-14 00:00:00
abstract::A non-classical light source emitting pairs of identical photons represents a versatile resource of interdisciplinary importance with applications in quantum optics and quantum biology. To date, photon twins have mostly been generated using parametric downconversion sources, relying on Poissonian number distributions,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14870
更新日期:2017-04-03 00:00:00
abstract::Gross chromosomal rearrangements (GCRs), such as translocations, deletions or inversions, are often generated by illegitimate repair between two DNA breakages at regions with nucleotide sequences that might potentially adopt a non-B DNA conformation. We previously established a plasmid-based model system that recapitu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2595
更新日期:2013-01-01 00:00:00
abstract::The dynamic incorporation of histone variants influences chromatin structure and many biological processes. In Arabidopsis, the canonical variant H3.1 differs from H3.3 in four residues, one of which (H3.1Phe41) is unique and conserved in plants. However, its evolutionary significance remains unclear. Here, we show th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02976-9
更新日期:2018-02-12 00:00:00
abstract::The original version of this Article contained errors in Fig. 3. In panel a, bars from a chart depicting the percentage of antibody-positive individuals in non-infectious and infectious groups were inadvertently included in place of bars depicting the percentage of infectious individuals, as described in the Article a...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03769-w
更新日期:2018-04-11 00:00:00
abstract::Proteins are versatile natural building blocks with highly complex and multifunctional architectures, and self-assembled protein structures have been created by the introduction of covalent, noncovalent, or metal-coordination bonding. Here, we report the robust, selective, and reversible metal coordination properties ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13491-w
更新日期:2019-12-05 00:00:00
abstract::HER2-targeted therapy has yielded a significant clinical benefit in patients with HER2+ breast cancer, yet disease relapse due to intrinsic or acquired resistance remains a significant challenge in the clinic. Here, we show that the protein phosphatase 2A (PP2A) regulatory subunit PPP2R2B is a crucial determinant of a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19704-x
更新日期:2020-11-18 00:00:00
abstract::Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02722-7
更新日期:2018-01-30 00:00:00
abstract::Pseudo-topotactic conversion of carbon nanotubes into one-dimensional carbon nanowires is a challenging but feasible path to obtain desired diameters and morphologies. Here, a previously predicted but experimentally unobserved carbon allotrope, T-carbon, has been produced from pseudo-topotactic conversion of a multi-w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00817-9
更新日期:2017-09-25 00:00:00