Abstract：
:Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sensed by the peroxiredoxin Tsa1 and transduced to thioredoxin, to counteract PKA-dependent Msn2 phosphorylation. Upon H2O2, the nuclear retention of PKA catalytic subunits, which contributes to delayed Msn2 nuclear concentration, is antagonized in a Tsa1-dependent manner. Conversely, peroxiredoxin hyperoxidation interrupts the H2O2 signal and drives Msn2 oscillations by superimposing on PKA feedback regulation. Our data identify a mechanism by which light could be sensed in all cells lacking dedicated photoreceptors. In particular, the use of H2O2 as a second messenger in signalling is common to Msn2 oscillations and to light-induced entrainment of circadian rhythms and suggests conserved roles for peroxiredoxins in endogenous rhythms.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Bodvard K,Peeters K,Roger F,Romanov N,Igbaria A,Welkenhuysen N,Palais G,Reiter W,Toledano MB,Käll M,Molin Mdoi
10.1038/ncomms14791subject
Has Abstractpub_date
2017-03-24 00:00:00pages
14791issn
2041-1723pii
ncomms14791journal_volume
8pub_type
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