Cellular senescence drives age-dependent hepatic steatosis.

abstract：:The elastic-to-plastic transition during the deformation of a dislocation-free nanoscale volume is accompanied by displacement bursts associated with dislocation nucleation. The dislocations that nucleate during the so-called "pop-in" burst take the form of prismatic dislocation loops (PDLs) and exhibit characteristic...

journal_title：Nature communications

authors： Lee S,Vaid A,Im J,Kim B,Prakash A,Guénolé J,Kiener D,Bitzek E,Oh SH

更新日期：2020-05-12 00:00:00

abstract：:Electrodynamic responses from three-dimensional topological insulators are characterized by the universal magnetoelectric term constituent of the Lagrangian formalism. The quantized magnetoelectric coupling, which is generally referred to as topological magnetoelectric effect, has been predicted to induce exotic pheno...

journal_title：Nature communications

authors： Okada KN,Takahashi Y,Mogi M,Yoshimi R,Tsukazaki A,Takahashi KS,Ogawa N,Kawasaki M,Tokura Y

更新日期：2016-07-20 00:00:00

abstract：:Frequency tuning within the auditory papilla of most non-mammalian species is electrical, deriving from ion-channel resonance within their sensory hair cells. In contrast, tuning within the mammalian cochlea is mechanical, stemming from active mechanisms within outer hair cells that amplify the basilar membrane travel...

journal_title：Nature communications

authors： Xia A,Liu X,Raphael PD,Applegate BE,Oghalai JS

更新日期：2016-10-31 00:00:00

abstract：:DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...

journal_title：Nature communications

authors： Adam S,Anteneh H,Hornisch M,Wagner V,Lu J,Radde NE,Bashtrykov P,Song J,Jeltsch A

更新日期：2020-07-24 00:00:00

abstract：:Nanostructured materials premise to revolutionize the label-free biosensing of analytes for clinical applications, leveraging the deeper interaction between materials and analytes with comparable size. However, when the characteristic dimension of the materials reduces to the nanoscale, the surface functionalization f...

journal_title：Nature communications

authors： Mariani S,Robbiano V,Strambini LM,Debrassi A,Egri G,Dähne L,Barillaro G

更新日期：2018-12-10 00:00:00

abstract：:A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability an...

journal_title：Nature communications

authors： Guiziou S,Mayonove P,Bonnet J

更新日期：2019-01-28 00:00:00

abstract：:The history of the Earth has been marked by major ecological transitions, driven by metabolic innovation, that radically reshaped the composition of the oceans and atmosphere. The nature and magnitude of the earliest transitions, hundreds of million years before photosynthesis evolved, remain poorly understood. Using ...

journal_title：Nature communications

authors： Sauterey B,Charnay B,Affholder A,Mazevet S,Ferrière R

更新日期：2020-06-01 00:00:00

abstract：:Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kina...

journal_title：Nature communications

authors： Wang Y,Kim J,Schmit MB,Cho TS,Fang C,Cai H

更新日期：2019-06-24 00:00:00

abstract：:Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these cellular decisions is achieved remains elusive. The Wilms' tumour suppressor Wt1 is required for progenitor survival, but the molecular cause for renal agenesis in mu...

journal_title：Nature communications

authors： Motamedi FJ,Badro DA,Clarkson M,Lecca MR,Bradford ST,Buske FA,Saar K,Hübner N,Brändli AW,Schedl A

更新日期：2014-07-17 00:00:00

abstract：:The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis that negatively regulates cell growth and survival. Here we report that Yes-associated protein (YAP), the terminal effector of the Hippo pathway, interacts with FoxO1 in the nucleus of cardiomyocytes, thereby promoting survival....

journal_title：Nature communications

authors： Shao D,Zhai P,Del Re DP,Sciarretta S,Yabuta N,Nojima H,Lim DS,Pan D,Sadoshima J

更新日期：2014-01-01 00:00:00

abstract：:A universally accepted explanation for why liquids sometimes vitrify rather than crystallize remains hotly pursued, despite the ubiquity of glass in our everyday lives, the utilization of the glass transition in innumerable modern technologies, and nearly a century of theoretical and experimental investigation. Among ...

journal_title：Nature communications

authors： Teich EG,van Anders G,Glotzer SC

更新日期：2019-01-08 00:00:00

abstract：:Humans typically make near-optimal sensorimotor judgements but show systematic biases when making more cognitive judgements. Here we test the hypothesis that, while humans are sensitive to the noise present during early sensory encoding, the "optimality gap" arises because they are blind to noise introduced by later c...

journal_title：Nature communications

authors： Herce Castañón S,Moran R,Ding J,Egner T,Bang D,Summerfield C

更新日期：2019-04-12 00:00:00

abstract：:Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and complex splicing patterns. Direct RNA sequencing (direct RNA-seq) using nanopore arrays offers an exciting alternative whereby individual polyadenylated RNAs are se...

journal_title：Nature communications

authors： Depledge DP,Srinivas KP,Sadaoka T,Bready D,Mori Y,Placantonakis DG,Mohr I,Wilson AC

更新日期：2019-02-14 00:00:00

abstract：:Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively...

journal_title：Nature communications

authors： Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X

更新日期：2016-08-26 00:00:00

abstract：:The modern energy economy and environmental infrastructure rely on the flow of fluids through fractures in rock. Yet this flow cannot be imaged directly because rocks are opaque to most probes. Here we apply chattering dust, or chemically reactive grains of sucrose containing pockets of pressurized carbon dioxide, to ...

journal_title：Nature communications

authors： Pyrak-Nolte LJ,Braverman W,Nolte NJ,Wright AJ,Nolte DD

更新日期：2020-10-19 00:00:00

abstract：:Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics. Here we describe the design and development of the Alphabody, a protein scaffold featuring a single-chain antiparallel triple-helix coiled-coil fold. We report affinity-...

journal_title：Nature communications

authors： Desmet J,Verstraete K,Bloch Y,Lorent E,Wen Y,Devreese B,Vandenbroucke K,Loverix S,Hettmann T,Deroo S,Somers K,Henderikx P,Lasters I,Savvides SN

更新日期：2014-10-30 00:00:00

abstract：:NaK and other non-selective channels are able to conduct both sodium (Na+) and potassium (K+) with equally high efficiency. In contrast to previous crystallographic results, we show that the selectivity filter (SF) of NaK in native-like lipid membranes adopts two distinct conformations that are stabilized by either Na...

journal_title：Nature communications

authors： Shi C,He Y,Hendriks K,de Groot BL,Cai X,Tian C,Lange A,Sun H

更新日期：2018-02-19 00:00:00

abstract：:The original version of this Article was missing the ORCID ID of Professor Nicola Pugno.Also in the original version of this Article, the third to last sentence of the fourth paragraph of the Results incorrectly read 'However, the stepwise addition of CNTs increases the self-entanglement and thereby the compressive st...

journal_title：Nature communications

authors： Schütt F,Signetti S,Krüger H,Röder S,Smazna D,Kaps S,Gorb SN,Mishra YK,Pugno NM,Adelung R

更新日期：2018-01-09 00:00:00

abstract：:Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation...

journal_title：Nature communications

authors： Díaz-Muñoz MD,Kiselev VY,Le Novère N,Curk T,Ule J,Turner M

更新日期：2017-09-13 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15587. ...

journal_title：Nature communications

authors： Yu T,Zhou YJ,Wenning L,Liu Q,Krivoruchko A,Siewers V,Nielsen J,David F

更新日期：2018-07-13 00:00:00

abstract：:A challenge for neuroscience is to understand the conscious and unconscious processes underlying construction of willed actions. We investigated the neural substrate of human motor awareness during awake brain surgery. In a first experiment, awake patients performed a voluntary hand motor task and verbally monitored t...

journal_title：Nature communications

authors： Fornia L,Puglisi G,Leonetti A,Bello L,Berti A,Cerri G,Garbarini F

更新日期：2020-02-04 00:00:00

abstract：:Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. The mPFC contains multiple types of pyramidal cells, but it is unclear whether a particular subtype mediates th...

journal_title：Nature communications

authors： Hare BD,Shinohara R,Liu RJ,Pothula S,DiLeone RJ,Duman RS

更新日期：2019-01-15 00:00:00

abstract：:Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...

journal_title：Nature communications

authors： Bradshaw CJ,Leroy B,Bellard C,Roiz D,Albert C,Fournier A,Barbet-Massin M,Salles JM,Simard F,Courchamp F

更新日期：2016-10-04 00:00:00

abstract：:Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, which phosphorylates DH...

journal_title：Nature communications

authors： Hao JW,Wang J,Guo H,Zhao YY,Sun HH,Li YF,Lai XY,Zhao N,Wang X,Xie C,Hong L,Huang X,Wang HR,Li CB,Liang B,Chen S,Zhao TJ

更新日期：2020-09-21 00:00:00

abstract：:International corporations in an increasingly globalized economy exert a major influence on the planet's land use and resources through their product design and material sourcing decisions. Many companies use life cycle assessment (LCA) to evaluate their sustainability, yet commonly-used LCA methodologies lack the spa...

journal_title：Nature communications

authors： Chaplin-Kramer R,Sim S,Hamel P,Bryant B,Noe R,Mueller C,Rigarlsford G,Kulak M,Kowal V,Sharp R,Clavreul J,Price E,Polasky S,Ruckelshaus M,Daily G

更新日期：2017-04-21 00:00:00

abstract：:In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggr...

journal_title：Nature communications

authors： Qi N,Shi Y,Zhang R,Zhu W,Yuan B,Li X,Wang C,Zhang X,Hou F

更新日期：2017-06-13 00:00:00

abstract：:Broomcorn millet (Panicum miliaceum L.) has strong tolerance to abiotic stresses, and is probably one of the oldest crops, with its earliest cultivation that dated back to ca. ~10,000 years. We report here its genome assembly through a combination of PacBio sequencing, BioNano, and Hi-C (in vivo) mapping. The 18 super...

journal_title：Nature communications

authors： Shi J,Ma X,Zhang J,Zhou Y,Liu M,Huang L,Sun S,Zhang X,Gao X,Zhan W,Li P,Wang L,Lu P,Zhao H,Song W,Lai J

更新日期：2019-01-25 00:00:00

abstract：:The ribosome stalls on translation of polyproline sequences due to inefficient peptide bond formation between consecutive prolines. The translation factor EF-P is able to alleviate this stalling by accelerating Pro-Pro formation. However, the mechanism by which EF-P recognizes the stalled complexes and accelerates pep...

journal_title：Nature communications

authors： Katoh T,Wohlgemuth I,Nagano M,Rodnina MV,Suga H

更新日期：2016-05-24 00:00:00

abstract：:The original version of this Article omitted the Received and Accepted dates; they should have been 22nd January 2018 and 19th April 2018, respectively. This has been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Wu Y,Wang G,Li Q,Xiang J,Jiang H,Wang Y

更新日期：2018-06-13 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00