A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response.

abstract：:Modern ab initio calculations predict ionic and superionic states in highly compressed water and ammonia. The prediction apparently contradicts state-of-the-art experimentally established phase diagrams overwhelmingly dominated by molecular phases. Here we present experimental evidence that the threshold pressure of ~...

journal_title：Nature communications

authors： Palasyuk T,Troyan I,Eremets M,Drozd V,Medvedev S,Zaleski-Ejgierd P,Magos-Palasyuk E,Wang H,Bonev SA,Dudenko D,Naumov P

更新日期：2014-03-24 00:00:00

abstract：:Supercooled liquids exhibit spatial heterogeneity in the dynamics of their fluctuating atomic arrangements. The length and time scales of the heterogeneous dynamics are central to the glass transition and influence nucleation and growth of crystals from the liquid. Here, we report direct experimental visualization of ...

journal_title：Nature communications

authors： Zhang P,Maldonis JJ,Liu Z,Schroers J,Voyles PM

更新日期：2018-03-19 00:00:00

abstract：:Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) en...

journal_title：Nature communications

authors： Huynh N,Ou Q,Cox P,Lill R,King-Jones K

更新日期：2019-11-29 00:00:00

abstract：:In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled ...

journal_title：Nature communications

authors： Zhang Y,Tsang TK,Bushong EA,Chu LA,Chiang AS,Ellisman MH,Reingruber J,Su CY

更新日期：2019-04-05 00:00:00

abstract：:Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%...

journal_title：Nature communications

authors： Garcia-Basteiro AL,Moncunill G,Tortajada M,Vidal M,Guinovart C,Jiménez A,Santano R,Sanz S,Méndez S,Llupià A,Aguilar R,Alonso S,Barrios D,Carolis C,Cisteró P,Chóliz E,Cruz A,Fochs S,Jairoce C,Hecht J,Lamoglia M,M

更新日期：2020-07-08 00:00:00

abstract：:Electrodynamic responses from three-dimensional topological insulators are characterized by the universal magnetoelectric term constituent of the Lagrangian formalism. The quantized magnetoelectric coupling, which is generally referred to as topological magnetoelectric effect, has been predicted to induce exotic pheno...

journal_title：Nature communications

authors： Okada KN,Takahashi Y,Mogi M,Yoshimi R,Tsukazaki A,Takahashi KS,Ogawa N,Kawasaki M,Tokura Y

更新日期：2016-07-20 00:00:00

abstract：:Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous f...

journal_title：Nature communications

authors： Brina D,Miluzio A,Ricciardi S,Clarke K,Davidsen PK,Viero G,Tebaldi T,Offenhäuser N,Rozman J,Rathkolb B,Neschen S,Klingenspor M,Wolf E,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Quattrone A,Falciani F,Biffo S

更新日期：2015-09-18 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subt...

journal_title：Nature communications

authors： Ahn JH,Lee HS,Lee JS,Lee YS,Park JL,Kim SY,Hwang JA,Kunkeaw N,Jung SY,Kim TJ,Lee KS,Jeon SH,Lee I,Johnson BH,Choi JH,Lee YS

更新日期：2018-03-21 00:00:00

abstract：:Black silicon is a synthetic nanomaterial that contains high aspect ratio nanoprotrusions on its surface, produced through a simple reactive-ion etching technique for use in photovoltaic applications. Surfaces with high aspect-ratio nanofeatures are also common in the natural world, for example, the wings of the drago...

journal_title：Nature communications

authors： Ivanova EP,Hasan J,Webb HK,Gervinskas G,Juodkazis S,Truong VK,Wu AH,Lamb RN,Baulin VA,Watson GS,Watson JA,Mainwaring DE,Crawford RJ

更新日期：2013-01-01 00:00:00

abstract：:Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for...

journal_title：Nature communications

authors： Yim N,Ryu SW,Choi K,Lee KR,Lee S,Choi H,Kim J,Shaker MR,Sun W,Park JH,Kim D,Heo WD,Choi C

更新日期：2016-07-22 00:00:00

abstract：:Each skeletal muscle acquires its unique size before birth, when terminally differentiating myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which the transcription factor Myogenin is mutated lack most myogenesis and die perinatally, a specific cell biological role for Myogenin has ...

journal_title：Nature communications

authors： Ganassi M,Badodi S,Ortuste Quiroga HP,Zammit PS,Hinits Y,Hughes SM

更新日期：2018-10-12 00:00:00

abstract：:Scintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C...

journal_title：Nature communications

authors： Xu LJ,Lin X,He Q,Worku M,Ma B

更新日期：2020-08-28 00:00:00

abstract：:Insight into crumpling or compaction of one-dimensional objects is important for understanding biopolymer packaging and designing innovative technological devices. By compacting various types of wires in rigid confinements and characterizing the morphology of the resulting crumpled structures, here, we report how fric...

journal_title：Nature communications

authors： Shaebani MR,Najafi J,Farnudi A,Bonn D,Habibi M

更新日期：2017-06-06 00:00:00

abstract：:Sponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symbioses. Here we present a global Porifera microbiome survey, set out to establish the ecological and evolutionary drivers of these host-microbe interactions. We show that sponges are a reservoir of exceptional microbia...

journal_title：Nature communications

authors： Thomas T,Moitinho-Silva L,Lurgi M,Björk JR,Easson C,Astudillo-García C,Olson JB,Erwin PM,López-Legentil S,Luter H,Chaves-Fonnegra A,Costa R,Schupp PJ,Steindler L,Erpenbeck D,Gilbert J,Knight R,Ackermann G,Victor Lopez

更新日期：2016-06-16 00:00:00

abstract：:Photocatalysis has not found widespread industrial adoption, in spite of decades of active research, because the challenges associated with catalyst illumination and turnover outweigh the touted advantages of replacing heat with light. A demonstration that light can control product selectivity in complex chemical reac...

journal_title：Nature communications

authors： Zhang X,Li X,Zhang D,Su NQ,Yang W,Everitt HO,Liu J

更新日期：2017-02-23 00:00:00

abstract：:Theoretical and experimental results have revealed that the lithium-ion storage capacity for nitrogen-doped graphene largely depends on the nitrogen-doping level. However, most nitrogen-doped carbon materials used for lithium-ion batteries are reported to have a nitrogen content of approximately 10 wt% because a highe...

journal_title：Nature communications

authors： Zheng F,Yang Y,Chen Q

更新日期：2014-11-06 00:00:00

abstract：:Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...

journal_title：Nature communications

authors： Jin W,Kim HH,Ye Z,Ye G,Rojas L,Luo X,Yang B,Yin F,Horng JSA,Tian S,Fu Y,Xu G,Deng H,Lei H,Tsen AW,Sun K,He R,Zhao L

更新日期：2020-09-22 00:00:00

abstract：:Nanofabricated and nanopatterned surfaces have revealed the sensitivity of cell adhesion to nanoscale variations in the spacing of adhesive ligands such as the tripeptide arginine-glycine-aspartic acid (RGD). To date, surface characterisation and cell adhesion are often examined in two separate experiments so that the...

journal_title：Nature communications

authors： Lu X,Nicovich PR,Zhao M,Nieves DJ,Mollazade M,Vivekchand SRC,Gaus K,Gooding JJ

更新日期：2018-08-20 00:00:00

abstract：:Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked to tumorigenesis, rheumatoid arthritis and heart disease. Here we show that pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating intermolecular-disu...

journal_title：Nature communications

authors： Burgoyne JR,Rudyk O,Cho HJ,Prysyazhna O,Hathaway N,Weeks A,Evans R,Ng T,Schröder K,Brandes RP,Shah AM,Eaton P

更新日期：2015-08-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Temko D,Tomlinson IPM,Severini S,Schuster-Böckler B,Graham TA

更新日期：2020-04-20 00:00:00

abstract：:Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...

journal_title：Nature communications

authors： Artiglia L,Edebeli J,Orlando F,Chen S,Lee MT,Corral Arroyo P,Gilgen A,Bartels-Rausch T,Kleibert A,Vazdar M,Andres Carignano M,Francisco JS,Shepson PB,Gladich I,Ammann M

更新日期：2017-09-26 00:00:00

abstract：:Ocean ventilation is the integrated effect of various processes that exchange surface properties with the ocean interior and is essential for oxygen supply, storage of anthropogenic carbon and the heat budget of the ocean, for instance. Current observational methods utilise transient tracers, e.g. tritium, SF6, CFCs a...

journal_title：Nature communications

authors： Ebser S,Kersting A,Stöven T,Feng Z,Ringena L,Schmidt M,Tanhua T,Aeschbach W,Oberthaler MK

更新日期：2018-11-28 00:00:00

abstract：:Symbiotic associations occur in every habitat on earth, but we know very little about their evolutionary histories. Current models of trait evolution cannot adequately reconstruct the deep history of symbiotic innovation, because they assume homogenous evolutionary processes across millions of years. Here we use a rec...

journal_title：Nature communications

authors： Werner GD,Cornwell WK,Sprent JI,Kattge J,Kiers ET

更新日期：2014-06-10 00:00:00

abstract：:A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

journal_title：Nature communications

authors： Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

更新日期：2019-07-09 00:00:00

abstract：:FoxO proteins are major targets of insulin action. To better define the role of FoxO1 in mediating insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice. Here we show that LIRKO mice are severely insulin resistant based on glucose, insuli...

journal_title：Nature communications

authors： O-Sullivan I,Zhang W,Wasserman DH,Liew CW,Liu J,Paik J,DePinho RA,Stolz DB,Kahn CR,Schwartz MW,Unterman TG

更新日期：2015-05-12 00:00:00

abstract：:The early diversification of animals (∼ 630 Ma), and their development into both motile and macroscopic forms (∼ 575-565 Ma), has been linked to stepwise increases in the oxygenation of Earth's surface environment. However, establishing such a linkage between oxygen and evolution for the later Cambrian 'explosion' (54...

journal_title：Nature communications

authors： Chen X,Ling HF,Vance D,Shields-Zhou GA,Zhu M,Poulton SW,Och LM,Jiang SY,Li D,Cremonese L,Archer C

更新日期：2015-05-18 00:00:00

abstract：:Chirality is an intriguing property of certain molecules, materials or artificial nanostructures, which allows them to interact with the spin angular momentum of the impinging light field. Due to their chiral geometry, they can distinguish between left- and right-hand circular polarization states or convert them into ...

journal_title：Nature communications

authors： Banzer P,Woźniak P,Mick U,De Leon I,Boyd RW

更新日期：2016-10-13 00:00:00

abstract：:An effective way to improve polymer solar cell efficiency is to use a tandem structure, as a broader part of the spectrum of solar radiation is used and the thermalization loss of photon energy is minimized. In the past, the lack of high-performance low-bandgap polymers was the major limiting factor for achieving high...

journal_title：Nature communications

authors： You J,Dou L,Yoshimura K,Kato T,Ohya K,Moriarty T,Emery K,Chen CC,Gao J,Li G,Yang Y

更新日期：2013-01-01 00:00:00

abstract：:Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...

journal_title：Nature communications

authors： Tsutsui KI,Grabenhorst F,Kobayashi S,Schultz W

更新日期：2016-09-13 00:00:00

abstract：:A subtle balance between competing interactions in iron-based superconductors (FeSCs) can be tipped by additional interfacial interactions in a heterostructure, often inducing exotic phases with unprecedented properties. Particularly when the proximity-coupled layer is magnetically active, rich phase diagrams are expe...

journal_title：Nature communications

authors： Ok JM,Baek SH,Hoch C,Kremer RK,Park SY,Ji S,Büchner B,Park JH,Hyun SI,Shim JH,Bang Y,Moon EG,Mazin II,Kim JS

更新日期：2017-12-18 00:00:00