Abstract:
:In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled by the same tungsten electrode to demonstrate that direct electrical ("ephaptic") interactions mediate lateral inhibition between ORNs. Intriguingly, within individual sensilla, we find that ephaptic lateral inhibition is asymmetric such that one ORN exerts greater influence onto its neighbor. Serial block-face scanning electron microscopy of genetically identified ORNs and circuit modeling indicate that asymmetric lateral inhibition reflects a surprisingly simple mechanism: the physically larger ORN in a pair corresponds to the dominant neuron in ephaptic interactions. Thus, morphometric differences between compartmentalized ORNs account for highly specialized inhibitory interactions that govern information processing at the earliest stages of olfactory coding.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Zhang Y,Tsang TK,Bushong EA,Chu LA,Chiang AS,Ellisman MH,Reingruber J,Su CYdoi
10.1038/s41467-019-09346-zsubject
Has Abstractpub_date
2019-04-05 00:00:00pages
1560issue
1issn
2041-1723pii
10.1038/s41467-019-09346-zjournal_volume
10pub_type
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