Causal associations between risk factors and common diseases inferred from GWAS summary data.

Abstract:

:Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a multi-SNP Mendelian randomization analysis using summary-level data from genome-wide association studies to test the causal associations of BMI, waist-to-hip ratio, serum cholesterols, blood pressures, height, and years of schooling (EduYears) with common diseases (sample sizes of up to 405,072). We identify a number of causal associations including a protective effect of LDL-cholesterol against type-2 diabetes (T2D) that might explain the side effects of statins on T2D, a protective effect of EduYears against Alzheimer's disease, and bidirectional associations with opposite effects (e.g., higher BMI increases the risk of T2D but the effect of T2D on BMI is negative).

journal_name

Nat Commun

journal_title

Nature communications

authors

Zhu Z,Zheng Z,Zhang F,Wu Y,Trzaskowski M,Maier R,Robinson MR,McGrath JJ,Visscher PM,Wray NR,Yang J

doi

10.1038/s41467-017-02317-2

subject

Has Abstract

pub_date

2018-01-15 00:00:00

pages

224

issue

1

issn

2041-1723

pii

10.1038/s41467-017-02317-2

journal_volume

9

pub_type

杂志文章
  • Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma.

    abstract::Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a p...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms13568

    authors: Ming XY,Fu L,Zhang LY,Qin YR,Cao TT,Chan KW,Ma S,Xie D,Guan XY

    更新日期:2016-12-07 00:00:00

  • The genomic landscape of pediatric myelodysplastic syndromes.

    abstract::Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequenci...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-01590-5

    authors: Schwartz JR,Ma J,Lamprecht T,Walsh M,Wang S,Bryant V,Song G,Wu G,Easton J,Kesserwan C,Nichols KE,Mullighan CG,Ribeiro RC,Klco JM

    更新日期:2017-11-16 00:00:00

  • High performance platinum single atom electrocatalyst for oxygen reduction reaction.

    abstract::For the large-scale sustainable implementation of polymer electrolyte membrane fuel cells in vehicles, high-performance electrocatalysts with low platinum consumption are desirable for use as cathode material during the oxygen reduction reaction in fuel cells. Here we report a carbon black-supported cost-effective, ef...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15938

    authors: Liu J,Jiao M,Lu L,Barkholtz HM,Li Y,Wang Y,Jiang L,Wu Z,Liu DJ,Zhuang L,Ma C,Zeng J,Zhang B,Su D,Song P,Xing W,Xu W,Wang Y,Jiang Z,Sun G

    更新日期:2017-07-24 00:00:00

  • Molecular basis for PrimPol recruitment to replication forks by RPA.

    abstract::DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most eukaryotic cells contain a multifunctional replicative enzyme called prim...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15222

    authors: Guilliam TA,Brissett NC,Ehlinger A,Keen BA,Kolesar P,Taylor EM,Bailey LJ,Lindsay HD,Chazin WJ,Doherty AJ

    更新日期:2017-05-23 00:00:00

  • Binary tree-inspired digital dendrimer.

    abstract::Digital polymers with precisely ordered units acting as the coded 0- or 1-bit, are introduced as a promising option for molecular data storage. However, the pursuit of better performance in terms of high storage capacity and useful functions never stops. Herein, we propose a concept of an information-coded 2D digital ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09957-6

    authors: Huang Z,Shi Q,Guo J,Meng F,Zhang Y,Lu Y,Qian Z,Li X,Zhou N,Zhang Z,Zhu X

    更新日期:2019-04-23 00:00:00

  • Coordination mode engineering in stacked-nanosheet metal-organic frameworks to enhance catalytic reactivity and structural robustness.

    abstract::Optimising the supported modes of atom or ion dispersal onto substrates, to synchronously integrate high reactivity and robust stability in catalytic conversion, is an important yet challenging area of research. Here, theoretical calculations first show that three-coordinated copper (Cu) sites have higher activity tha...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-10547-9

    authors: Huang C,Dong J,Sun W,Xue Z,Ma J,Zheng L,Liu C,Li X,Zhou K,Qiao X,Song Q,Ma W,Zhang L,Lin Z,Wang T

    更新日期:2019-06-25 00:00:00

  • Cooperative material transport during the early stage of sintering.

    abstract::The complex transport processes contributing to sintering are not yet fully understood, partially because in-situ observations of sintering in three dimensions (3D) are very difficult. Here we report a novel experiment in which monocrystalline copper spheres are first marked with microscopic boreholes drilled using a ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1300

    authors: Grupp R,Nöthe M,Kieback B,Banhart J

    更新日期:2011-01-01 00:00:00

  • Author Correction: Large intrinsic anomalous Hall effect in half-metallic ferromagnet Co3Sn2S2 with magnetic Weyl fermions.

    abstract::The original version of this Article incorrectly omitted an affiliation of Hongming Weng: "Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, China"This has been corrected in both the PDF and HTML versions of the Article. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41467-018-06643-x

    authors: Wang Q,Xu Y,Lou R,Liu Z,Li M,Huang Y,Shen D,Weng H,Wang S,Lei H

    更新日期:2018-10-08 00:00:00

  • Evidence for a palaeo-subglacial lake on the Antarctic continental shelf.

    abstract::Subglacial lakes are widespread beneath the Antarctic Ice Sheet but their control on ice-sheet dynamics and their ability to harbour life remain poorly characterized. Here we present evidence for a palaeo-subglacial lake on the Antarctic continental shelf. A distinct sediment facies recovered from a bedrock basin in P...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15591

    authors: Kuhn G,Hillenbrand CD,Kasten S,Smith JA,Nitsche FO,Frederichs T,Wiers S,Ehrmann W,Klages JP,Mogollón JM

    更新日期:2017-06-01 00:00:00

  • PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.

    abstract::Mutations in patatin-like phospholipase domain-containing 1 (PNPLA1) cause autosomal recessive congenital ichthyosis, but the mechanism involved remains unclear. Here we show that PNPLA1, an enzyme expressed in differentiated keratinocytes, plays a crucial role in the biosynthesis of ω-O-acylceramide, a lipid componen...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms14609

    authors: Hirabayashi T,Anjo T,Kaneko A,Senoo Y,Shibata A,Takama H,Yokoyama K,Nishito Y,Ono T,Taya C,Muramatsu K,Fukami K,Muñoz-Garcia A,Brash AR,Ikeda K,Arita M,Akiyama M,Murakami M

    更新日期:2017-03-01 00:00:00

  • Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy.

    abstract::The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11838

    authors: Pérez-Medina C,Abdel-Atti D,Tang J,Zhao Y,Fayad ZA,Lewis JS,Mulder WJM,Reiner T

    更新日期:2016-06-20 00:00:00

  • Publisher Correction: Unveiling the Re effect in Ni-based single crystal superalloys.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Nature communications

    pub_type: 已发布勘误

    doi:10.1038/s41467-020-14820-0

    authors: Wu X,Makineni SK,Liebscher CH,Dehm G,Mianroodi JR,Shanthraj P,Svendsen B,Bürger D,Eggeler G,Raabe D,Gault B

    更新日期:2020-02-21 00:00:00

  • Single spin localization and manipulation in graphene open-shell nanostructures.

    abstract::Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-08060-6

    authors: Li J,Sanz S,Corso M,Choi DJ,Peña D,Frederiksen T,Pascual JI

    更新日期:2019-01-14 00:00:00

  • CREB controls cortical circuit plasticity and functional recovery after stroke.

    abstract::Treatments that stimulate neuronal excitability enhance motor performance after stroke. cAMP-response-element binding protein (CREB) is a transcription factor that plays a key role in neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool of motor neurons enhances motor recovery after...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-04445-9

    authors: Caracciolo L,Marosi M,Mazzitelli J,Latifi S,Sano Y,Galvan L,Kawaguchi R,Holley S,Levine MS,Coppola G,Portera-Cailliau C,Silva AJ,Carmichael ST

    更新日期:2018-06-08 00:00:00

  • Engineering modular intracellular protein sensor-actuator devices.

    abstract::Understanding and reshaping cellular behaviors with synthetic gene networks requires the ability to sense and respond to changes in the intracellular environment. Intracellular proteins are involved in almost all cellular processes, and thus can provide important information about changes in cellular conditions such a...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03984-5

    authors: Siciliano V,DiAndreth B,Monel B,Beal J,Huh J,Clayton KL,Wroblewska L,McKeon A,Walker BD,Weiss R

    更新日期:2018-05-14 00:00:00

  • Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.

    abstract::Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12738

    authors: Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

    更新日期:2016-09-27 00:00:00

  • Understanding catalysis in a multiphasic two-dimensional transition metal dichalcogenide.

    abstract::Establishing processing-structure-property relationships for monolayer materials is crucial for a range of applications spanning optics, catalysis, electronics and energy. Presently, for molybdenum disulfide, a promising catalyst for artificial photosynthesis, considerable debate surrounds the structure/property relat...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9311

    authors: Chou SS,Sai N,Lu P,Coker EN,Liu S,Artyushkova K,Luk TS,Kaehr B,Brinker CJ

    更新日期:2015-10-07 00:00:00

  • Decadal predictions of the North Atlantic CO2 uptake.

    abstract::As a major CO2 sink, the North Atlantic, especially its subpolar gyre region, is essential for the global carbon cycle. Decadal fluctuations of CO2 uptake in the North Atlantic subpolar gyre region are associated with the evolution of the North Atlantic Oscillation, the Atlantic meridional overturning circulation, oce...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11076

    authors: Li H,Ilyina T,Müller WA,Sienz F

    更新日期:2016-03-30 00:00:00

  • Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress.

    abstract::A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15868

    authors: Gusarov I,Pani B,Gautier L,Smolentseva O,Eremina S,Shamovsky I,Katkova-Zhukotskaya O,Mironov A,Nudler E

    更新日期:2017-06-19 00:00:00

  • Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.

    abstract::The long external filament of bacterial flagella is composed of several thousand copies of a single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in Salmonella, which requires the methylase FliB. We show that both flagellins of Salmonella enterica serovar Typhimurium, FliC and...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-15738-3

    authors: Horstmann JA,Lunelli M,Cazzola H,Heidemann J,Kühne C,Steffen P,Szefs S,Rossi C,Lokareddy RK,Wang C,Lemaire L,Hughes KT,Uetrecht C,Schlüter H,Grassl GA,Stradal TEB,Rossez Y,Kolbe M,Erhardt M

    更新日期:2020-04-24 00:00:00

  • Anomalous circular bulk photovoltaic effect in BiFeO3 thin films with stripe-domain pattern.

    abstract::Multiferroic bismuth ferrite, BiFeO3, offers a vast landscape to study the interplay between different ferrroic orders. Another aspect which is equally exciting, and yet underutilized, is the possibility of large-scale ordering of domains. Along with symmetry-driven bulk photovoltaic effect, BiFeO3 presents opportunit...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20446-z

    authors: Knoche DS,Steimecke M,Yun Y,Mühlenbein L,Bhatnagar A

    更新日期:2021-01-12 00:00:00

  • Nanocasting SiO2 into metal-organic frameworks imparts dual protection to high-loading Fe single-atom electrocatalysts.

    abstract::Single-atom catalysts (SACs) have sparked broad interest recently while the low metal loading poses a big challenge for further applications. Herein, a dual protection strategy has been developed to give high-content SACs by nanocasting SiO2 into porphyrinic metal-organic frameworks (MOFs). The pyrolysis of SiO2@MOF c...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-16715-6

    authors: Jiao L,Zhang R,Wan G,Yang W,Wan X,Zhou H,Shui J,Yu SH,Jiang HL

    更新日期:2020-06-05 00:00:00

  • Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.

    abstract::Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-00341-w

    authors: Paldy E,Simonetti M,Worzfeld T,Bali KK,Vicuña L,Offermanns S,Kuner R

    更新日期:2017-08-02 00:00:00

  • Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.

    abstract::Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and a...

    journal_title:Nature communications

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41467-017-01973-8

    authors: Duvallet C,Gibbons SM,Gurry T,Irizarry RA,Alm EJ

    更新日期:2017-12-05 00:00:00

  • Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination.

    abstract::Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-19730-9

    authors: Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

    更新日期:2020-11-17 00:00:00

  • Relativistic and resonant effects in the ionization of heavy atoms by ultra-intense hard X-rays.

    abstract::An accurate description of the interaction of intense hard X-ray pulses with heavy atoms, which is crucial for many applications of free-electron lasers, represents a hitherto unresolved challenge for theory because of the enormous number of electronic configurations and relativistic effects, which need to be taken in...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06745-6

    authors: Rudek B,Toyota K,Foucar L,Erk B,Boll R,Bomme C,Correa J,Carron S,Boutet S,Williams GJ,Ferguson KR,Alonso-Mori R,Koglin JE,Gorkhover T,Bucher M,Lehmann CS,Krässig B,Southworth SH,Young L,Bostedt C,Ueda K,Marchenk

    更新日期:2018-10-10 00:00:00

  • Single-pass transformation of syngas into ethanol with high selectivity by triple tandem catalysis.

    abstract::Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-14672-8

    authors: Kang J,He S,Zhou W,Shen Z,Li Y,Chen M,Zhang Q,Wang Y

    更新日期:2020-02-11 00:00:00

  • Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase.

    abstract::The originally published version of this Article contained an error in the spelling of the author Md. Saiful Islam, which was incorrectly given as Saiful Islam. This has now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41467-018-04196-7

    authors: Wilkins SE,Islam MS,Gannon JM,Markolovic S,Hopkinson RJ,Ge W,Schofield CJ,Chowdhury R

    更新日期:2018-04-23 00:00:00

  • Nanoelectromechanical coupling in fullerene peapods probed by resonant electrical transport experiments.

    abstract::Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1034

    authors: Utko P,Ferone R,Krive IV,Shekhter RI,Jonson M,Monthioux M,Noé L,Nygård J

    更新日期:2010-07-13 00:00:00

  • In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release.

    abstract::Transcribing and replicating a double-stranded genome require protein modules to unwind, transcribe/replicate nucleic acid substrates, and release products. Here we present in situ cryo-electron microscopy structures of rotavirus dsRNA-dependent RNA polymerase (RdRp) in two states pertaining to transcription. In addit...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-10236-7

    authors: Ding K,Celma CC,Zhang X,Chang T,Shen W,Atanasov I,Roy P,Zhou ZH

    更新日期:2019-05-17 00:00:00