A single evolutionary innovation drives the deep evolution of symbiotic N2-fixation in angiosperms.

abstract：:The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respirato...

journal_title：Nature communications

authors： Gancheva S,Ouni M,Jelenik T,Koliaki C,Szendroedi J,Toledo FGS,Markgraf DF,Pesta DH,Mastrototaro L,De Filippo E,Herder C,Jähnert M,Weiss J,Strassburger K,Schlensak M,Schürmann A,Roden M

更新日期：2019-09-13 00:00:00

abstract：:The observations of solar flare onsets show rapid increase of hard and soft X-rays, ultra-violet emission with large Doppler blue shifts associated with plasma upflows, and Hα hydrogen emission with red shifts up to 1-4 Å. Modern radiative hydrodynamic models account well for blue-shifted emission, but struggle to rep...

journal_title：Nature communications

authors： Druett M,Scullion E,Zharkova V,Matthews S,Zharkov S,Rouppe Van der Voort L

更新日期：2017-06-27 00:00:00

abstract：:Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches to create a mouse model with high metastatic potential. Construc...

journal_title：Nature communications

authors： Chanrion M,Kuperstein I,Barrière C,El Marjou F,Cohen D,Vignjevic D,Stimmer L,Paul-Gilloteaux P,Bièche I,Tavares Sdos R,Boccia GF,Cacheux W,Meseure D,Fre S,Martignetti L,Legoix-Né P,Girard E,Fetler L,Barillot E,Louva

更新日期：2014-10-08 00:00:00

abstract：:DNA methylation plays important roles in prokaryotes, and their genomic landscapes-prokaryotic epigenomes-have recently begun to be disclosed. However, our knowledge of prokaryotic methylation systems is focused on those of culturable microbes, which are rare in nature. Here, we used single-molecule real-time and circ...

journal_title：Nature communications

authors： Hiraoka S,Okazaki Y,Anda M,Toyoda A,Nakano SI,Iwasaki W

更新日期：2019-01-11 00:00:00

abstract：:We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its ...

journal_title：Nature communications

authors： Ferreira JCB,Campos JC,Qvit N,Qi X,Bozi LHM,Bechara LRG,Lima VM,Queliconi BB,Disatnik MH,Dourado PMM,Kowaltowski AJ,Mochly-Rosen D

更新日期：2019-01-18 00:00:00

abstract：:Neuroimaging modalities such as MRI and EEG are able to record from the whole brain, but this comes at the price of either limited spatiotemporal resolution or limited sensitivity. Here, we show that functional ultrasound imaging (fUS) of the brain is able to assess local changes in cerebral blood volume during cognit...

journal_title：Nature communications

authors： Dizeux A,Gesnik M,Ahnine H,Blaize K,Arcizet F,Picaud S,Sahel JA,Deffieux T,Pouget P,Tanter M

更新日期：2019-03-28 00:00:00

abstract：:Determining nanoscale protein distribution via Photoactivated Localization Microscopy (PALM) mandates precise knowledge of the applied fluorophore's blinking properties to counteract overcounting artifacts that distort the resulting biomolecular distributions. Here, we present a readily applicable methodology to deter...

journal_title：Nature communications

authors： Platzer R,Rossboth BK,Schneider MC,Sevcsik E,Baumgart F,Stockinger H,Schütz GJ,Huppa JB,Brameshuber M

更新日期：2020-10-05 00:00:00

abstract：:The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose a scan statistic framework, WGScan, to simultaneously detect the existence, and estimate t...

journal_title：Nature communications

authors： He Z,Xu B,Buxbaum J,Ionita-Laza I

更新日期：2019-07-09 00:00:00

abstract：:The only known compound of sodium and hydrogen is archetypal ionic NaH. Application of high pressure is known to promote states with higher atomic coordination, but extensive searches for polyhydrides with unusual stoichiometry have had only limited success in spite of several theoretical predictions. Here we report t...

journal_title：Nature communications

authors： Struzhkin VV,Kim DY,Stavrou E,Muramatsu T,Mao HK,Pickard CJ,Needs RJ,Prakapenka VB,Goncharov AF

更新日期：2016-07-28 00:00:00

abstract：:Gas-sensing materials are becoming increasingly important in our society, requiring high sensitivity to differentiate similar gases like N2 and O2. For the design of such materials, the driving force of electronic host-guest interaction or host-framework changes during the sorption process has commonly been considered...

journal_title：Nature communications

authors： Kosaka W,Liu Z,Zhang J,Sato Y,Hori A,Matsuda R,Kitagawa S,Miyasaka H

更新日期：2018-12-21 00:00:00

abstract：:One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) ...

journal_title：Nature communications

authors： Du X,Dong L,Lan Y,Peng Y,Wu A,Zhang Y,Huang W,Wang D,Wang M,Guo Y,Shu Y,Jiang T

更新日期：2012-02-28 00:00:00

abstract：:Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are not currently available. Here, we isolate and characterize four monoclonal ant...

journal_title：Nature communications

authors： Bailey MJ,Duehr J,Dulin H,Broecker F,Brown JA,Arumemi FO,Bermúdez González MC,Leyva-Grado VH,Evans MJ,Simon V,Lim JK,Krammer F,Hai R,Palese P,Tan GS

更新日期：2018-11-01 00:00:00

abstract：:In two-dimensional (2D) lattices, the electronic levels are unevenly spaced, and the density of states (DOS) displays a logarithmic divergence known as the Van Hove singularity (VHS). This is the case in particular for the layered cuprate superconductors. The scanning tunnelling microscope (STM) probes the DOS, and is...

journal_title：Nature communications

authors： Piriou A,Jenkins N,Berthod C,Maggio-Aprile I,Fischer O

更新日期：2011-01-01 00:00:00

abstract：:Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...

journal_title：Nature communications

authors： Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

更新日期：2015-07-28 00:00:00

abstract：:Multi-partite entangled states are important for developing studies of quantum networking and quantum computation. To date, the largest number of particles that have been successfully manipulated is 14 trapped ions. Yet in quantum information science, photons have partic...

journal_title：Nature communications

authors： Huang YF,Liu BH,Peng L,Li YH,Li L,Li CF,Guo GC

更新日期：2011-11-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Paulevé L,Kolčák J,Chatain T,Haar S

更新日期：2020-09-24 00:00:00

abstract：:Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56A...

journal_title：Nature communications

authors： Topal S,Vasseur P,Radman-Livaja M,Peterson CL

更新日期：2019-09-26 00:00:00

abstract：:Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking sign...

journal_title：Nature communications

authors： Chen S,Augustine GJ,Chadderton P

更新日期：2017-08-10 00:00:00

abstract：:In eukaryotic cells, organellar proteome biogenesis is pivotal for cellular function. Chloroplasts contain a complex proteome, the biogenesis of which includes post-translational import of nuclear-encoded proteins. However, the mechanisms determining when and how nascent chloroplast-targeted proteins are sorted in the...

journal_title：Nature communications

authors： Kim DH,Lee JE,Xu ZY,Geem KR,Kwon Y,Park JW,Hwang I

更新日期：2015-04-16 00:00:00

abstract：:Shear-wave anisotropy in Earth's mantle helps constrain the lattice-preferred orientation of anisotropic minerals due to viscous flow. Previous studies at the Japan Trench subduction zone using land-based seismic networks identified strong anisotropy in the mantle wedge, reflecting viscous flow induced by the subducti...

journal_title：Nature communications

authors： Uchida N,Nakajima J,Wang K,Takagi R,Yoshida K,Nakayama T,Hino R,Okada T,Asano Y

更新日期：2020-11-10 00:00:00

abstract：:Engineering intramolecular exchange interactions between magnetic metal atoms is a ubiquitous strategy for designing molecular magnets. For lanthanides, the localized nature of 4f electrons usually results in weak exchange coupling. Mediating magnetic interactions between lanthanide ions via radical bridges is a fruit...

journal_title：Nature communications

authors： Liu F,Velkos G,Krylov DS,Spree L,Zalibera M,Ray R,Samoylova NA,Chen CH,Rosenkranz M,Schiemenz S,Ziegs F,Nenkov K,Kostanyan A,Greber T,Wolter AUB,Richter M,Büchner B,Avdoshenko SM,Popov AA

更新日期：2019-02-04 00:00:00

abstract：:Evidence from animal and human studies has suggested that the amygdala plays a role in detecting threat and in directing attention to the eyes. Nevertheless, there has been no systematic investigation of whether the amygdala specifically facilitates attention to the eyes or whether other features can also drive attent...

journal_title：Nature communications

authors： Dal Monte O,Costa VD,Noble PL,Murray EA,Averbeck BB

更新日期：2015-12-14 00:00:00

abstract：:Social dilemmas force players to balance between personal and collective gain. In many dilemmas, such as elected governments negotiating climate-change mitigation measures, the decisions are made not by individual players but by their representatives. However, the behaviour of representatives in social dilemmas has no...

journal_title：Nature communications

authors： Milinski M,Hilbe C,Semmann D,Sommerfeld R,Marotzke J

更新日期：2016-03-07 00:00:00

abstract：:The search for two-dimensional quantum spin liquids, exotic magnetic states remaining disordered down to zero temperature, has been a great challenge in frustrated magnetism over the last few decades. Recently, evidence for fractionalized excitations, called spinons, emerging from these states has been observed in kag...

journal_title：Nature communications

authors： Lhotel E,Petit S,Ciomaga Hatnean M,Ollivier J,Mutka H,Ressouche E,Lees MR,Balakrishnan G

更新日期：2018-09-17 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. S...

journal_title：Nature communications

authors： Choi SY,Bae H,Jeong SH,Park I,Cho H,Hong SP,Lee DH,Lee CK,Park JS,Suh SH,Choi J,Yang MJ,Jang JY,Onder L,Moon JH,Jeong HS,Adams RH,Kim JM,Ludewig B,Song JH,Lim DS,Koh GY

更新日期：2020-01-24 00:00:00

abstract：:Coupling between vibrational modes is essential for energy transfer and dissipation in condensed matter. For water, different O-H stretch modes are known to be very strongly coupled both within and between water molecules, leading to ultrafast dissipation and delocalization of vibrational energy. In contrast, the info...

journal_title：Nature communications

authors： Yu CC,Chiang KY,Okuno M,Seki T,Ohto T,Yu X,Korepanov V,Hamaguchi HO,Bonn M,Hunger J,Nagata Y

更新日期：2020-11-25 00:00:00

abstract：:The Warburg effect is a prominent metabolic feature associated with neoplastic diseases; however, the underlying mechanism remains incompletely understood. TAp73, a structural homolog of the tumor suppressor p53, is frequently overexpressed in human tumors, indicating a proliferative advantage that it can confer to tu...

journal_title：Nature communications

authors： Li L,Li L,Li W,Chen T,Bin Zou,Zhao L,Wang H,Wang X,Xu L,Liu X,Wang D,Li B,Mak TW,Du W,Yang X,Jiang P

更新日期：2018-11-08 00:00:00

abstract：:Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, including cancer and neurological disorders. While BER is well studied on naked DNA, it remains uncl...

journal_title：Nature communications

authors： Montaldo NP,Bordin DL,Brambilla A,Rösinger M,Fordyce Martin SL,Bjørås KØ,Bradamante S,Aas PA,Furrer A,Olsen LC,Kunath N,Otterlei M,Sætrom P,Bjørås M,Samson LD,van Loon B

更新日期：2019-11-29 00:00:00

abstract：:Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), whic...

journal_title：Nature communications

authors： Wei Y,Wang D,Jin F,Bian Z,Li L,Liang H,Li M,Shi L,Pan C,Zhu D,Chen X,Hu G,Liu Y,Zhang CY,Zen K

更新日期：2017-01-09 00:00:00

abstract：:The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation seq...

journal_title：Nature communications

authors： Elhaik E,Tatarinova T,Chebotarev D,Piras IS,Maria Calò C,De Montis A,Atzori M,Marini M,Tofanelli S,Francalacci P,Pagani L,Tyler-Smith C,Xue Y,Cucca F,Schurr TG,Gaieski JB,Melendez C,Vilar MG,Owings AC,Gómez R,Fuji

更新日期：2014-04-29 00:00:00