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Distinct transcriptional roles for Histone H3-K56 acetylation during the cell cycle in Yeast.

Abstract：

:Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56Ac on transcription throughout the yeast cell cycle. We find that H3K56Ac is a genome-wide activator of transcription. While H3K56Ac has a major impact on transcription initiation, it also appears to promote elongation and/or termination. In contrast, H3K56Ac represses promiscuous transcription that occurs immediately following replication fork passage, in this case by promoting efficient nucleosome assembly. We also detect a stepwise increase in transcription as cells transit S phase and enter G2, but this response to increased gene dosage does not require H3K56Ac. Thus, a single histone mark can exert both positive and negative impacts on transcription that are coupled to different cell cycle events.

journal_name

Nat Commun

journal_title

Nature communications

authors

Topal S,Vasseur P,Radman-Livaja M,Peterson CL

doi

10.1038/s41467-019-12400-5

subject

Has Abstract

pub_date

2019-09-26 00:00:00

pages

4372

issue

1

issn

2041-1723

pii

10.1038/s41467-019-12400-5

journal_volume

10

pub_type

杂志文章

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