Abstract：
:We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its GTPase activity and in a buildup of fragmented and dysfunctional mitochondria in heart failure. βIIPKC siRNA or a βIIPKC inhibitor mitigates mitochondrial fragmentation and cell death. We confirm that Mfn1-βIIPKC interaction alone is critical in inhibiting mitochondrial function and cardiac myocyte viability using SAMβA, a rationally-designed peptide that selectively antagonizes Mfn1-βIIPKC association. SAMβA treatment protects cultured neonatal and adult cardiac myocytes, but not Mfn1 knockout cells, from stress-induced death. Importantly, SAMβA treatment re-establishes mitochondrial morphology and function and improves cardiac contractility in rats with heart failure, suggesting that SAMβA may be a potential treatment for patients with heart failure.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ferreira JCB,Campos JC,Qvit N,Qi X,Bozi LHM,Bechara LRG,Lima VM,Queliconi BB,Disatnik MH,Dourado PMM,Kowaltowski AJ,Mochly-Rosen Ddoi
10.1038/s41467-018-08276-6subject
Has Abstractpub_date
2019-01-18 00:00:00pages
329issue
1issn
2041-1723pii
10.1038/s41467-018-08276-6journal_volume
10pub_type
杂志文章abstract：:Cardiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric activity by initiating and propagating action potentials in the heart. Altered Nav1.5 function is associated with multiple cardiac diseases including long-QT3 and Brugada syndrome. Here, we show that Nav1.5 is subject ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12035
更新日期：2016-06-23 00:00:00
abstract：:Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating processes within complex biological assemblies. Imaging mass spectrometry (IMS) is a powerful emerging tool for mapping the spatial distribution of...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13858-z
更新日期：2020-01-07 00:00:00
abstract：:Random numbers are commonly used in many different fields, ranging from simulations in fundamental science to security applications. In some critical cases, as Bell's tests and cryptography, the random numbers are required to be both private and to be provided at an ultra-fast rate. However, practical generators are u...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07585-0
更新日期：2018-12-18 00:00:00
abstract：:Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02722-7
更新日期：2018-01-30 00:00:00
abstract：:The Fanconi anaemia (FA) pathway is important for the repair of DNA interstrand crosslinks (ICL). The FANCD2-FANCI complex is central to the pathway, and localizes to ICLs dependent on its monoubiquitination. It has remained elusive whether the complex is recruited before or after the critical monoubiquitination. Here...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12124
更新日期：2016-07-13 00:00:00
abstract：:Recent expansion of croplands in the United States has caused widespread conversion of grasslands and other ecosystems with largely unknown consequences for agricultural production and the environment. Here we assess annual land use change 2008-16 and its impacts on crop yields and wildlife habitat. We find that cropl...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18045-z
更新日期：2020-09-09 00:00:00
abstract：:Most DNA in the genomes of higher organisms does not encode proteins, yet much is transcribed by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The biological significance of most lncRNAs is largely unclear. Here, we identify a lncRNA (SVALKA) in a cold-sensitive region of the Arabidopsis genome. Muta...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07010-6
更新日期：2018-11-01 00:00:00
abstract：:The original version of this Article contained an error in the spelling of the author David Bulkley, which was incorrectly given as David Bulkey. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-019-09422-4
更新日期：2019-03-26 00:00:00
abstract：:Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads. Here we report a 'synapse microarray' technology that enables ultra-sensitive, high-throughput and quantitative screening of synaptogenesis. Our platform enables ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1518
更新日期：2011-10-25 00:00:00
abstract：:Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a ∼400 kDa five-subunit catalytic core. Here we characterize a hypothetical ∼100 kDa single-chain protein, YonO, encoded by the SPβ prophage of Bacillus subti...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15774
更新日期：2017-06-06 00:00:00
abstract：:A magnetic impurity coupled to a superconductor gives rise to a Yu-Shiba-Rusinov (YSR) state inside the superconducting energy gap. With increasing exchange coupling the excitation energy of this state eventually crosses zero and the system switches to a YSR ground state with bound quasiparticles screening the impurit...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04683-x
更新日期：2018-06-18 00:00:00
abstract：:Circadian rhythms of cell division have been observed in several lineages of eukaryotes, especially photosynthetic unicellular eukaryotes. However, the mechanism underlying the circadian regulation of the cell cycle and the nature of the advantage conferred remain unknown. Here, using the unicellular red alga Cyanidio...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4807
更新日期：2014-05-08 00:00:00
abstract：:The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing dat...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13225-y
更新日期：2019-11-28 00:00:00
abstract：:Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-de...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09302-x
更新日期：2019-03-19 00:00:00
abstract：:5-Methylfurfural (MF) is a very useful chemical. Selective hydrogenation of biomass platform molecule 5-(hydroxymethyl)furfural (HMF) to MF using H2 as the reducing agent is very attractive, but challenging because hydrogenation of C=O bond in HMF is more favourable than C-OH both kinetically and thermodynamically, an...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20878-7
更新日期：2021-01-26 00:00:00
abstract：:The worldwide biodiversity crisis has intensified the need to better understand how biodiversity and human disturbance are related. The 'intermediate disturbance hypothesis' suggests that disturbance regimes generate predictable non-linear patterns in species richness. Evidence often contradicts intermediate disturban...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2145
更新日期：2012-01-01 00:00:00
abstract：:The central phenomenon in the field of organic spintronics is the large magnetoresistance in thick organic spin valves. A prerequisite for understanding the magnetoresistance is a reliable description of the device resistance, or the I-V characteristics. Here I show that the observed I-V characteristics in the organic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5842
更新日期：2014-09-09 00:00:00
abstract：:Inspired by biological neural systems, neuromorphic devices may open up new computing paradigms to explore cognition, learning and limits of parallel computation. Here we report the demonstration of a synaptic transistor with SmNiO₃, a correlated electron system with insulator-metal transition temperature at 130°C in ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3676
更新日期：2013-01-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/ncomms15533. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/ncomms16129
更新日期：2017-07-04 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-020-17422-y
更新日期：2020-07-21 00:00:00
abstract：:Vibrio parahaemolyticus is the leading cause of seafood-borne diarrheal diseases. Experimental overproduction of a type 3 secretion system (T3SS1) in this pathogen leads to decreased intestinal colonization, which suggests that T3SS1 repression is required for maximal virulence. However, the mechanisms by which T3SS1 ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19506-1
更新日期：2020-11-13 00:00:00
abstract：:A subset of transcription factors classified as neural crest 'specifiers' are also core epithelial-mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The bHLH factor Twist is among the least well studied of these factors. Here we demonstrate that Twist is required for crania...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2543
更新日期：2013-01-01 00:00:00
abstract：:Intermolecular halogen bonds are ideally suited for designing new molecular assemblies because of their strong directionality and the possibility of tuning the interactions by using different types of halogens or molecular moieties. Due to these unique properties of the halogen bonds, numerous areas of application hav...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19379-4
更新日期：2020-11-06 00:00:00
abstract：:In the originally published version of this Article, the affiliation details for Eric E. Schadt and Radoslav Savic incorrectly omitted 'Sema4, a Mount Sinai venture, Stamford, Connecticut, USA'. This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-07326-3
更新日期：2018-11-19 00:00:00
abstract：:Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3569
更新日期：2013-01-01 00:00:00
abstract：:Global fish production (capture and aquaculture) has increased quickly, which has altered global flows of phosphorus (P). Here we show that in 2016, [Formula: see text] Tg P yr-1 (mean and interquartile range) was applied in aquaculture to increase fish production; while [Formula: see text] Tg P yr-1 was removed from ...
journal_title：Nature communications
pub_type： 历史文章,杂志文章
doi：10.1038/s41467-019-14242-7
更新日期：2020-01-17 00:00:00
abstract：:Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05795-0
更新日期：2018-08-22 00:00:00
abstract：:Photosynthesis is nature's route to convert intermittent solar irradiation into storable energy, while its use for an industrial energy supply is impaired by low efficiency. Artificial photosynthesis provides a promising alternative for efficient robust carbon-neutral renewable energy generation. The approach of direc...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9286
更新日期：2015-09-15 00:00:00
abstract：:The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation seq...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4513
更新日期：2014-04-29 00:00:00
abstract：:Monolayer molybdenum disulfide (MoS2) has attracted tremendous attention due to its promising applications in high-performance field-effect transistors, phototransistors, spintronic devices and nonlinear optics. The enhanced photoluminescence effect in monolayer MoS2 was discovered and, as a strong tool, was employed ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6246
更新日期：2014-11-18 00:00:00
