Corrigendum: The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing.

abstract：:Nanoparticles hosted in conductive matrices are ubiquitous in electrochemical energy storage, catalysis and energetic devices. However, agglomeration and surface oxidation remain as two major challenges towards their ultimate utility, especially for highly reactive materials. Here we report uniformly distributed nanop...

journal_title：Nature communications

authors： Chen Y,Egan GC,Wan J,Zhu S,Jacob RJ,Zhou W,Dai J,Wang Y,Danner VA,Yao Y,Fu K,Wang Y,Bao W,Li T,Zachariah MR,Hu L

更新日期：2016-08-12 00:00:00

abstract：:Metallic nanostructures exhibit a multitude of optical resonances associated with localized surface plasmon excitations. Recent observations of plasmonic phenomena at the sub-nanometre to atomic scale have stimulated the development of various sophisticated theoretical approaches for their description. Here instead we...

journal_title：Nature communications

authors： Mortensen NA,Raza S,Wubs M,Søndergaard T,Bozhevolnyi SI

更新日期：2014-05-02 00:00:00

abstract：:CD4(+) Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of encephalitogenic Th cells expressing RORγt and T-bet and producing IL-17A, IFN-γ and GM-CSF but not IL-10...

journal_title：Nature communications

authors： Ronchi F,Basso C,Preite S,Reboldi A,Baumjohann D,Perlini L,Lanzavecchia A,Sallusto F

更新日期：2016-05-18 00:00:00

abstract：:The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the s...

journal_title：Nature communications

authors： GeurtsvanKessel CH,Okba NMA,Igloi Z,Bogers S,Embregts CWE,Laksono BM,Leijten L,Rokx C,Rijnders B,Rahamat-Langendoen J,van den Akker JPC,van Kampen JJA,van der Eijk AA,van Binnendijk RS,Haagmans B,Koopmans M

更新日期：2020-07-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Rees-Garbutt J,Chalkley O,Landon S,Purcell O,Marucci L,Grierson C

更新日期：2020-05-06 00:00:00

abstract：:The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells....

journal_title：Nature communications

authors： Bunnik EM,Cook KB,Varoquaux N,Batugedara G,Prudhomme J,Cort A,Shi L,Andolina C,Ross LS,Brady D,Fidock DA,Nosten F,Tewari R,Sinnis P,Ay F,Vert JP,Noble WS,Le Roch KG

更新日期：2018-05-15 00:00:00

abstract：:Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equivalent ...

journal_title：Nature communications

authors： Baudoin M,Thomas JL,Sahely RA,Gerbedoen JC,Gong Z,Sivery A,Matar OB,Smagin N,Favreau P,Vlandas A

更新日期：2020-08-25 00:00:00

abstract：:As European heatwaves become more severe, summers in the United Kingdom (UK) are also getting warmer. The UK record temperature of 38.7 °C set in Cambridge in July 2019 prompts the question of whether exceeding 40 °C is now within reach. Here, we show how human influence is increasing the likelihood of exceeding 30, 3...

journal_title：Nature communications

authors： Christidis N,McCarthy M,Stott PA

更新日期：2020-06-30 00:00:00

abstract：:Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency of somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Treatment of relapsed aGCT remains a significant clinical challenge. Here we show, using whole-exome and cancer gene panel sequencing of 79 aGCTs from t...

journal_title：Nature communications

authors： Hillman RT,Celestino J,Terranova C,Beird HC,Gumbs C,Little L,Nguyen T,Thornton R,Tippen S,Zhang J,Lu KH,Gershenson DM,Rai K,Broaddus RR,Futreal PA

更新日期：2018-06-27 00:00:00

abstract：:A non-classical light source emitting pairs of identical photons represents a versatile resource of interdisciplinary importance with applications in quantum optics and quantum biology. To date, photon twins have mostly been generated using parametric downconversion sources, relying on Poissonian number distributions,...

journal_title：Nature communications

authors： Heindel T,Thoma A,von Helversen M,Schmidt M,Schlehahn A,Gschrey M,Schnauber P,Schulze JH,Strittmatter A,Beyer J,Rodt S,Carmele A,Knorr A,Reitzenstein S

更新日期：2017-04-03 00:00:00

abstract：:Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its efficacy are at present largely unknown. Here we sought to elucidate t...

journal_title：Nature communications

authors： Burrello C,Garavaglia F,Cribiù FM,Ercoli G,Lopez G,Troisi J,Colucci A,Guglietta S,Carloni S,Guglielmetti S,Taverniti V,Nizzoli G,Bosari S,Caprioli F,Rescigno M,Facciotti F

更新日期：2018-12-05 00:00:00

abstract：:Human activities are transforming grassland biomass via changing climate, elemental nutrients, and herbivory. Theory predicts that food-limited herbivores will consume any additional biomass stimulated by nutrient inputs ('consumer-controlled'). Alternatively, nutrient supply is predicted to increase biomass where her...

journal_title：Nature communications

authors： Borer ET,Harpole WS,Adler PB,Arnillas CA,Bugalho MN,Cadotte MW,Caldeira MC,Campana S,Dickman CR,Dickson TL,Donohue I,Eskelinen A,Firn JL,Graff P,Gruner DS,Heckman RW,Koltz AM,Komatsu KJ,Lannes LS,MacDougall AS,Mar

更新日期：2020-11-27 00:00:00

abstract：:To learn, obtain reward and survive, humans and other animals must monitor, approach and act on objects that are associated with variable or unknown rewards. However, the neuronal mechanisms that mediate behaviours aimed at uncertain objects are poorly understood. Here we demonstrate that a set of neurons in an intern...

journal_title：Nature communications

authors： White JK,Monosov IE

更新日期：2016-09-14 00:00:00

abstract：:Metal-support interaction is of great significance for catalysis as it can induce charge transfer between metal and support, tame electronic structure of supported metals, impact adsorption energy of reaction intermediates, and eventually change the catalytic performance. Here, we report the metal size-dependent charg...

journal_title：Nature communications

authors： Yan QQ,Wu DX,Chu SQ,Chen ZQ,Lin Y,Chen MX,Zhang J,Wu XJ,Liang HW

更新日期：2019-10-31 00:00:00

abstract：:Many biological processes involve large-scale changes in membrane shape. Computer simulations of these processes are challenging since they occur across a wide range of spatiotemporal scales that cannot be investigated in full by any single current simulation technique. A potential solution is to combine different lev...

journal_title：Nature communications

authors： Pezeshkian W,König M,Wassenaar TA,Marrink SJ

更新日期：2020-05-08 00:00:00

abstract：:Efficient and low-cost electrocatalysts for the oxygen evolution reaction are essential components of renewable energy technologies, such as solar fuel synthesis and providing a hydrogen source for powering fuel cells. Here we report that the nitrogen-doped carbon materials function as the efficient oxygen evolution e...

journal_title：Nature communications

authors： Zhao Y,Nakamura R,Kamiya K,Nakanishi S,Hashimoto K

更新日期：2013-01-01 00:00:00

abstract：:Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accur...

journal_title：Nature communications

authors： Goyette PA,Boulais É,Normandeau F,Laberge G,Juncker D,Gervais T

更新日期：2019-04-16 00:00:00

abstract：:The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing dat...

journal_title：Nature communications

authors： Delaneau O,Zagury JF,Robinson MR,Marchini JL,Dermitzakis ET

更新日期：2019-11-28 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA deletions remain unknown although several models have been proposed. Here we use deep sequencing to characterize abundant mtDNA deletions in patients with mutat...

journal_title：Nature communications

authors： Persson Ö,Muthukumar Y,Basu S,Jenninger L,Uhler JP,Berglund AK,McFarland R,Taylor RW,Gustafsson CM,Larsson E,Falkenberg M

更新日期：2019-02-15 00:00:00

abstract：:Thymic selection shapes an appropriate T cell antigen receptor (TCR) repertoire during T cell development. Here, we show that a serine/threonine kinase, protein kinase D (PKD), is crucial for thymocyte positive selection. In T cell-specific PKD-deficient (PKD2/PKD3 double-deficient) mice, the generation of CD4 single ...

journal_title：Nature communications

authors： Ishikawa E,Kosako H,Yasuda T,Ohmuraya M,Araki K,Kurosaki T,Saito T,Yamasaki S

更新日期：2016-09-27 00:00:00

abstract：:Damage to the genome is implicated in the progression of cancer and stress-induced diseases. DNA lesions exist in low levels, and cannot be amplified by standard PCR because they are frequently strong blocks to polymerases. Here, we describe a method for PCR amplification of lesion-containing DNA in which the site and...

journal_title：Nature communications

authors： Riedl J,Ding Y,Fleming AM,Burrows CJ

更新日期：2015-11-06 00:00:00

abstract：:Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequencing data such as t...

journal_title：Nature communications

authors： Mandric I,Rotman J,Yang HT,Strauli N,Montoya DJ,Van Der Wey W,Ronas JR,Statz B,Yao D,Petrova V,Zelikovsky A,Spreafico R,Shifman S,Zaitlen N,Rossetti M,Ansel KM,Eskin E,Mangul S

更新日期：2020-06-19 00:00:00

abstract：:Synapse formation is triggered through trans-synaptic interaction between pairs of pre- and postsynaptic adhesion molecules, the specificity of which depends on splice inserts known as 'splice-insert signaling codes'. Receptor protein tyrosine phosphatase δ (PTPδ) can bidirectionally induce pre- and postsynaptic diffe...

journal_title：Nature communications

authors： Yamagata A,Yoshida T,Sato Y,Goto-Ito S,Uemura T,Maeda A,Shiroshima T,Iwasawa-Okamoto S,Mori H,Mishina M,Fukai S

更新日期：2015-04-24 00:00:00

abstract：:Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility to CVID may overla...

journal_title：Nature communications

authors： Li J,Jørgensen SF,Maggadottir SM,Bakay M,Warnatz K,Glessner J,Pandey R,Salzer U,Schmidt RE,Perez E,Resnick E,Goldacker S,Buchta M,Witte T,Padyukov L,Videm V,Folseraas T,Atschekzei F,Elder JT,Nair RP,Winkelmann J,

更新日期：2015-04-20 00:00:00

abstract：:In November 2013, a series of earthquakes began along a mapped ancient fault system near Azle, Texas. Here we assess whether it is plausible that human activity caused these earthquakes. Analysis of both lake and groundwater variations near Azle shows that no significant stress changes were associated with the shallow...

journal_title：Nature communications

authors： Hornbach MJ,DeShon HR,Ellsworth WL,Stump BW,Hayward C,Frohlich C,Oldham HR,Olson JE,Magnani MB,Brokaw C,Luetgert JH

更新日期：2015-04-21 00:00:00

abstract：:The widespread CsrA/RsmA protein regulators repress translation by binding GGA motifs in bacterial mRNAs. CsrA activity is primarily controlled through sequestration by multiple small regulatory RNAs. Here we investigate CsrA activity control in the absence of antagonizing small RNAs by examining the CsrA regulon in t...

journal_title：Nature communications

authors： Dugar G,Svensson SL,Bischler T,Wäldchen S,Reinhardt R,Sauer M,Sharma CM

更新日期：2016-05-27 00:00:00

abstract：:The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...

journal_title：Nature communications

authors： Potticary J,Terry LR,Bell C,Papanikolopoulos AN,Christianen PC,Engelkamp H,Collins AM,Fontanesi C,Kociok-Köhn G,Crampin S,Da Como E,Hall SR

更新日期：2016-05-10 00:00:00

abstract：:Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show th...

journal_title：Nature communications

authors： Wang H,D'Souza C,Lim XY,Kostenko L,Pediongco TJ,Eckle SBG,Meehan BS,Shi M,Wang N,Li S,Liu L,Mak JYW,Fairlie DP,Iwakura Y,Gunnersen JM,Stent AW,Godfrey DI,Rossjohn J,Westall GP,Kjer-Nielsen L,Strugnell RA,McClusk

更新日期：2018-08-22 00:00:00

abstract：:Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...

journal_title：Nature communications

authors： Qiu L,Liu JZ,Chang SL,Wu Y,Li D

更新日期：2012-01-01 00:00:00

abstract：:Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...

journal_title：Nature communications

authors： Song L,Liu Z,Hu HH,Yang Y,Li TY,Lin ZZ,Ye J,Chen J,Huang X,Liu DT,Zhou J,Shi Y,Zhao H,Xie C,Chen L,Song E,Lin SY,Lin SC

更新日期：2020-11-17 00:00:00