Abstract:
:Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its efficacy are at present largely unknown. Here we sought to elucidate the functional effects of therapeutic FMT administration during experimental colitis on innate and adaptive immune responses in the intestinal mucosa. We show that therapeutic FMT reduces colonic inflammation and initiates the restoration of intestinal homeostasis through the simultaneous activation of different immune-mediated pathways, ultimately leading to IL-10 production by innate and adaptive immune cells, including CD4+ T cells, iNKT cells and Antigen Presenting Cells (APC), and reduces the ability of dendritic cells, monocytes and macrophages to present MHCII-dependent bacterial antigens to colonic T cells. These results demonstrate the capability of FMT to therapeutically control intestinal experimental colitis and poses FMT as a valuable therapeutic option in immune-related pathologies.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Burrello C,Garavaglia F,Cribiù FM,Ercoli G,Lopez G,Troisi J,Colucci A,Guglietta S,Carloni S,Guglielmetti S,Taverniti V,Nizzoli G,Bosari S,Caprioli F,Rescigno M,Facciotti Fdoi
10.1038/s41467-018-07359-8subject
Has Abstractpub_date
2018-12-05 00:00:00pages
5184issue
1issn
2041-1723pii
10.1038/s41467-018-07359-8journal_volume
9pub_type
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