当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Abstract：

:Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

journal_name

Nat Commun

journal_title

Nature communications

authors

Dadaev T,Saunders EJ,Newcombe PJ,Anokian E,Leongamornlert DA,Brook MN,Cieza-Borrella C,Mijuskovic M,Wakerell S,Olama AAA,Schumacher FR,Berndt SI,Benlloch S,Ahmed M,Goh C,Sheng X,Zhang Z,Muir K,Govindasami K,Lophatan

doi

10.1038/s41467-018-04109-8

subject

Has Abstract

pub_date

2018-06-11 00:00:00

pages

2256

issue

1

issn

2041-1723

pii

10.1038/s41467-018-04109-8

journal_volume

9

pub_type

杂志文章,meta分析

相关文献

Nature Communications文献大全
  • Transformation from crystalline precursor to perovskite in PbCl2-derived MAPbI3.

    abstract：:Understanding the formation chemistry of metal halide perovskites is key to optimizing processing conditions and realizing enhanced optoelectronic properties. Here, we reveal the structure of the crystalline precursor in the formation of methylammonium lead iodide (MAPbI3) from the single-step deposition of lead chlor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05937-4

    authors： Stone KH,Gold-Parker A,Pool VL,Unger EL,Bowring AR,McGehee MD,Toney MF,Tassone CJ

    更新日期：2018-08-27 00:00:00

  • NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia.

    abstract：:Chronic lymphocytic leukaemia (CLL) is a clonal disorder of mature B cells. Most patients are characterised by an indolent disease course and an anergic phenotype of their leukaemia cells, which refers to a state of unresponsiveness to B cell receptor stimulation. Up to 10% of CLL patients transform from an indolent s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00830-y

    authors： Märklin M,Heitmann JS,Fuchs AR,Truckenmüller FM,Gutknecht M,Bugl S,Saur SJ,Lazarus J,Kohlhofer U,Quintanilla-Martinez L,Rammensee HG,Salih HR,Kopp HG,Haap M,Kirschniak A,Kanz L,Rao A,Wirths S,Müller MR

    更新日期：2017-10-02 00:00:00

  • Urban areas as hotspots for bees and pollination but not a panacea for all insects.

    abstract：:Urbanisation is an important global driver of biodiversity change, negatively impacting some species groups whilst providing opportunities for others. Yet its impact on ecosystem services is poorly investigated. Here, using a replicated experimental design, we test how Central European cities impact flying insects and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14496-6

    authors： Theodorou P,Radzevičiūtė R,Lentendu G,Kahnt B,Husemann M,Bleidorn C,Settele J,Schweiger O,Grosse I,Wubet T,Murray TE,Paxton RJ

    更新日期：2020-01-29 00:00:00

  • Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.

    abstract：:The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14773

    authors： Kawamura A,Münzel M,Kojima T,Yapp C,Bhushan B,Goto Y,Tumber A,Katoh T,King ON,Passioura T,Walport LJ,Hatch SB,Madden S,Müller S,Brennan PE,Chowdhury R,Hopkinson RJ,Suga H,Schofield CJ

    更新日期：2017-04-06 00:00:00

  • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

    abstract：:Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidate mechanisms of adaptive resistance, we analyse the tumour immune mic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10501

    authors： Koyama S,Akbay EA,Li YY,Herter-Sprie GS,Buczkowski KA,Richards WG,Gandhi L,Redig AJ,Rodig SJ,Asahina H,Jones RE,Kulkarni MM,Kuraguchi M,Palakurthi S,Fecci PE,Johnson BE,Janne PA,Engelman JA,Gangadharan SP,Costa DB,

    更新日期：2016-02-17 00:00:00

  • Perfect proton selectivity in ion transport through two-dimensional crystals.

    abstract：:Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12314-2

    authors： Mogg L,Zhang S,Hao GP,Gopinadhan K,Barry D,Liu BL,Cheng HM,Geim AK,Lozada-Hidalgo M

    更新日期：2019-09-18 00:00:00

  • Quantifying cerebral contributions to pain beyond nociception.

    abstract：:Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14211

    authors： Woo CW,Schmidt L,Krishnan A,Jepma M,Roy M,Lindquist MA,Atlas LY,Wager TD

    更新日期：2017-02-14 00:00:00

  • Combining high-throughput phenotyping and genome-wide association studies to reveal natural genetic variation in rice.

    abstract：:Even as the study of plant genomics rapidly develops through the use of high-throughput sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-throughput rice phenotyping facility (HRPF) to monitor 13 traditional agronomic traits and 2 newly defined traits during the rice growth p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6087

    authors： Yang W,Guo Z,Huang C,Duan L,Chen G,Jiang N,Fang W,Feng H,Xie W,Lian X,Wang G,Luo Q,Zhang Q,Liu Q,Xiong L

    更新日期：2014-10-08 00:00:00

  • Efficient green light-emitting diodes based on quasi-two-dimensional composition and phase engineered perovskite with surface passivation.

    abstract：:Perovskite light-emitting diodes (LEDs) are attracting great attention due to their efficient and narrow emission. Quasi-two-dimensional perovskites with Ruddlesden-Popper-type layered structures can enlarge exciton binding energy and confine charge carriers and are considered good candidate materials for efficient LE...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-02978-7

    authors： Yang X,Zhang X,Deng J,Chu Z,Jiang Q,Meng J,Wang P,Zhang L,Yin Z,You J

    更新日期：2018-02-08 00:00:00

  • Silicate deposition during decomposition of cyanobacteria may promote export of picophytoplankton to the deep ocean.

    abstract：:Marine particles transport organic matter through the water column to the sediment where the organic matter can be buried. This pathway is one of the few natural removal mechanisms of CO2 from the atmosphere over geological time. Picophytoplankton, major primary producers in the ocean, have until recently been thought...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5143

    authors： Tang T,Kisslinger K,Lee C

    更新日期：2014-06-12 00:00:00

  • Chiral transcription in self-assembled tetrahedral Eu4L6 chiral cages displaying sizable circularly polarized luminescence.

    abstract：:Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01025-1

    authors： Yeung CT,Yim KH,Wong HY,Pal R,Lo WS,Yan SC,Yee-Man Wong M,Yufit D,Smiles DE,McCormick LJ,Teat SJ,Shuh DK,Wong WT,Law GL

    更新日期：2017-10-24 00:00:00

  • Tuning the activities of cuprous oxide nanostructures via the oxide-metal interaction.

    abstract：:Despite tremendous importance in catalysis, the design of oxide-metal interface has been hampered by the limited understanding of the nature of interfacial sites and the oxide-metal interaction (OMI). Through construction of well-defined Cu2O/Pt, Cu2O/Ag and Cu2O/Au interfaces, we find that Cu2O nanostructures (NSs) o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15965-8

    authors： Huang W,Liu Q,Zhou Z,Li Y,Ling Y,Wang Y,Tu Y,Wang B,Zhou X,Deng D,Yang B,Yang Y,Liu Z,Bao X,Yang F

    更新日期：2020-05-08 00:00:00

  • Carbon dioxide capture and conversion by an acid-base resistant metal-organic framework.

    abstract：:Considering the rapid increase of CO2 emission, especially from power plants, there is a constant need for materials which can effectively eliminate post-combustion CO2 (the main component: CO2/N2 = 15/85). Here, we show the design and synthesis of a Cu(II) metal-organic framework (FJI-H14) with a high density of acti...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01166-3

    authors： Liang L,Liu C,Jiang F,Chen Q,Zhang L,Xue H,Jiang HL,Qian J,Yuan D,Hong M

    更新日期：2017-11-01 00:00:00

  • Size-dependent diffusion controls natural aging in aluminium alloys.

    abstract：:A key question in materials science is how fast properties evolve, which relates to the kinetics of phase transformations. In metals, kinetics is primarily connected to diffusion, which for substitutional elements is enabled via mobile atomic-lattice vacancies. In fact, non-equilibrium vacancies are often required for...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12762-w

    authors： Dumitraschkewitz P,Uggowitzer PJ,Gerstl SSA,Löffler JF,Pogatscher S

    更新日期：2019-10-18 00:00:00

  • Entropy favors heterogeneous structures of networks near the rigidity threshold.

    abstract：:The dynamical properties and mechanical functions of amorphous materials are governed by their microscopic structures, particularly the elasticity of the interaction networks, which is generally complicated by structural heterogeneity. This ubiquitous heterogeneous nature of amorphous materials is intriguingly attribu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03859-9

    authors： Yan L

    更新日期：2018-04-10 00:00:00

  • Protecting tropical forests from the rapid expansion of rubber using carbon payments.

    abstract：:Expansion of Hevea brasiliensis rubber plantations is a resurgent driver of deforestation, carbon emissions, and biodiversity loss in Southeast Asia. Southeast Asian rubber extent is massive, equivalent to 67% of oil palm, with rapid further expansion predicted. Results-based carbon finance could dis-incentivise fores...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03287-9

    authors： Warren-Thomas EM,Edwards DP,Bebber DP,Chhang P,Diment AN,Evans TD,Lambrick FH,Maxwell JF,Nut M,O'Kelly HJ,Theilade I,Dolman PM

    更新日期：2018-03-02 00:00:00

  • Percolation transition of cooperative mutational effects in colorectal tumorigenesis.

    abstract：:Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01171-6

    authors： Shin D,Lee J,Gong JR,Cho KH

    更新日期：2017-11-02 00:00:00

  • Enthalpy-entropy compensation of atomic diffusion originates from softening of low frequency phonons.

    abstract：:Experimental data accumulated over more than 120 years show not only that diffusion coefficients of impurities ordinarily obey the Arrhenius law in crystalline solids, but also that diffusion pre-exponential factors measured in a same solid increase exponentially with activation energies. This so-called compensation e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17812-2

    authors： Gelin S,Champagne-Ruel A,Mousseau N

    更新日期：2020-08-07 00:00:00

  • Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer.

    abstract：:Enterobacteria, especially Escherichia coli, are abundant in patients with inflammatory bowel disease or colorectal cancer (CRC). However, it is unclear whether cancer is promoted by inflammation-induced expansion of E. coli and/or changes in expression of specific microbial genes. Here we use longitudinal (2, 12 and ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5724

    authors： Arthur JC,Gharaibeh RZ,Mühlbauer M,Perez-Chanona E,Uronis JM,McCafferty J,Fodor AA,Jobin C

    更新日期：2014-09-03 00:00:00

  • Modular optimization of multi-gene pathways for fatty acids production in E. coli.

    abstract：:Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2425

    authors： Xu P,Gu Q,Wang W,Wong L,Bower AG,Collins CH,Koffas MA

    更新日期：2013-01-01 00:00:00

  • Tornado outbreak variability follows Taylor's power law of fluctuation scaling and increases dramatically with severity.

    abstract：:Tornadoes cause loss of life and damage to property each year in the United States and around the world. The largest impacts come from 'outbreaks' consisting of multiple tornadoes closely spaced in time. Here we find an upward trend in the annual mean number of tornadoes per US tornado outbreak for the period 1954-201...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10668

    authors： Tippett MK,Cohen JE

    更新日期：2016-02-29 00:00:00

  • Summer warming explains widespread but not uniform greening in the Arctic tundra biome.

    abstract：:Arctic warming can influence tundra ecosystem function with consequences for climate feedbacks, wildlife and human communities. Yet ecological change across the Arctic tundra biome remains poorly quantified due to field measurement limitations and reliance on coarse-resolution satellite data. Here, we assess decadal c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18479-5

    authors： Berner LT,Massey R,Jantz P,Forbes BC,Macias-Fauria M,Myers-Smith I,Kumpula T,Gauthier G,Andreu-Hayles L,Gaglioti BV,Burns P,Zetterberg P,D'Arrigo R,Goetz SJ

    更新日期：2020-09-22 00:00:00

  • A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.

    abstract：:Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the choles...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07959-4

    authors： Mahoney CE,Pirman D,Chubukov V,Sleger T,Hayes S,Fan ZP,Allen EL,Chen Y,Huang L,Liu M,Zhang Y,McDonald G,Narayanaswamy R,Choe S,Chen Y,Gross S,Cianchetta G,Padyana AK,Murray S,Liu W,Marks KM,Murtie J,Dorsch M,

    更新日期：2019-01-09 00:00:00

  • IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.

    abstract：:Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients,...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03750-7

    authors： Wang S,Wang J,Kumar V,Karnell JL,Naiman B,Gross PS,Rahman S,Zerrouki K,Hanna R,Morehouse C,Holoweckyj N,Liu H,Autoimmunity Molecular Medicine Team.,Manna Z,Goldbach-Mansky R,Hasni S,Siegel R,Sanjuan M,Streicher K,Ca

    更新日期：2018-05-01 00:00:00

  • EPR-aided approach for solution structure determination of large RNAs or protein-RNA complexes.

    abstract：:High-resolution structural information on RNA and its functionally important complexes with proteins is dramatically underrepresented compared with proteins but is urgently needed for understanding cellular processes at the molecular and atomic level. Here we present an EPR-based protocol to help solving large RNA and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4669

    authors： Duss O,Yulikov M,Jeschke G,Allain FH

    更新日期：2014-05-14 00:00:00

  • LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation.

    abstract：:Though miR-205 function has been largely characterized, the nature of its host gene, MIR205HG, is still completely unknown. Here, we show that only lowly expressed alternatively spliced MIR205HG transcripts act as de facto pri-miRNAs, through a process that involves Drosha to prevent unfavorable splicing and directly ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08153-2

    authors： Profumo V,Forte B,Percio S,Rotundo F,Doldi V,Ferrari E,Fenderico N,Dugo M,Romagnoli D,Benelli M,Valdagni R,Dolfini D,Zaffaroni N,Gandellini P

    更新日期：2019-01-18 00:00:00

  • Impact-induced changes in source depth and volume of magmatism on Mercury and their observational signatures.

    abstract：:Mercury's crust is mostly the result of partial melting in the mantle associated with solid-state convection. Large impacts induce additional melting by generating subsurface thermal anomalies. By numerically investigating the geodynamical effects of impacts, here we show that impact-generated thermal anomalies intera...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01692-0

    authors： Padovan S,Tosi N,Plesa AC,Ruedas T

    更新日期：2017-12-05 00:00:00

  • New Blatter-type radicals from a bench-stable carbene.

    abstract：:Stable benzotriazinyl radicals (Blatter's radicals) recently attracted considerable interest as building blocks for functional materials. The existing strategies to derivatize Blatter's radicals are limited, however, and synthetic routes are complex. Here, we report that an inexpensive, commercially available, analyti...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15088

    authors： Grant JA,Lu Z,Tucker DE,Hockin BM,Yufit DS,Fox MA,Kataky R,Chechik V,O'Donoghue AC

    更新日期：2017-05-15 00:00:00

  • Dynamics of a qubit while simultaneously monitoring its relaxation and dephasing.

    abstract：:Decoherence originates from the leakage of quantum information into external degrees of freedom. For a qubit, the two main decoherence channels are relaxation and dephasing. Here, we report an experiment on a superconducting qubit where we retrieve part of the lost information in both of these channels. We demonstrate...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04372-9

    authors： Ficheux Q,Jezouin S,Leghtas Z,Huard B

    更新日期：2018-05-15 00:00:00

  • A TAL effector repeat architecture for frameshift binding.

    abstract：:Transcription activator-like effectors (TALEs) are important Xanthomonas virulence factors that bind DNA via a unique tandem 34-amino-acid repeat domain to induce expression of plant genes. So far, TALE repeats are described to bind as a consecutive array to a consecutive DNA sequence, in which each repeat independent...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4447

    authors： Richter A,Streubel J,Blücher C,Szurek B,Reschke M,Grau J,Boch J

    更新日期：2014-03-11 00:00:00