Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

abstract：:Neurotechnology attempts to develop supernumerary limbs, but can the human brain deal with the complexity to control an extra limb and yield advantages from it? Here, we analyzed the neuromechanics and manipulation abilities of two polydactyly subjects who each possess six fingers on their hands. Anatomical MRI of the...

journal_title：Nature communications

authors： Mehring C,Akselrod M,Bashford L,Mace M,Choi H,Blüher M,Buschhoff AS,Pistohl T,Salomon R,Cheah A,Blanke O,Serino A,Burdet E

更新日期：2019-06-03 00:00:00

abstract：:Emerging quantum technologies require mastering thermal management, especially at the nanoscale. It is now accepted that thermal metamaterial-based phonon manipulation is possible, especially at sub-kelvin temperatures. In these extreme limits of low temperatures and dimensions, heat conduction enters a quantum regime...

journal_title：Nature communications

authors： Tavakoli A,Lulla K,Crozes T,Mingo N,Collin E,Bourgeois O

更新日期：2018-10-16 00:00:00

abstract：:The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) in...

journal_title：Nature communications

authors： Matsuda T,Hiyama TY,Kobayashi K,Kobayashi K,Noda M

更新日期：2020-11-10 00:00:00

abstract：:Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship...

journal_title：Nature communications

authors： Parkinson C,Kleinbaum AM,Wheatley T

更新日期：2018-01-30 00:00:00

abstract：:Forests impact regional hydrology and climate directly by regulating water and heat fluxes. Indirect effects through cloud formation and precipitation can be important in facilitating continental-scale moisture recycling but are poorly understood at regional scales. In particular, the impact of temperate forest on clo...

journal_title：Nature communications

authors： Teuling AJ,Taylor CM,Meirink JF,Melsen LA,Miralles DG,van Heerwaarden CC,Vautard R,Stegehuis AI,Nabuurs GJ,de Arellano JV

更新日期：2017-01-11 00:00:00

abstract：:Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. We previously demonstrated that transcription factors GATA2 and MITF are the mast cell lineage-determining factors. However, it is unclear whether these lineage-determining factors regulate chromatin accessibility a...

journal_title：Nature communications

authors： Li Y,Gao J,Kamran M,Harmacek L,Danhorn T,Leach SM,O'Connor BP,Hagman JR,Huang H

更新日期：2021-01-21 00:00:00

abstract：:MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...

journal_title：Nature communications

authors： Ruelens P,de Maagd RA,Proost S,Theißen G,Geuten K,Kaufmann K

更新日期：2013-01-01 00:00:00

abstract：:Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue. Here we show that microRNA 155 is enriched in brown adipose tissue and is highly expressed in proliferating brown preadipocytes but declines after induction of ...

journal_title：Nature communications

authors： Chen Y,Siegel F,Kipschull S,Haas B,Fröhlich H,Meister G,Pfeifer A

更新日期：2013-01-01 00:00:00

abstract：:The striking diversity of bird beak shapes is an outcome of natural selection, yet the relative importance of the limitations imposed by the process of beak development on generating such variation is unclear. Untangling these factors requires mapping developmental mechanisms over a phylogeny far exceeding model syste...

journal_title：Nature communications

authors： Fritz JA,Brancale J,Tokita M,Burns KJ,Hawkins MB,Abzhanov A,Brenner MP

更新日期：2014-04-16 00:00:00

abstract：:Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar 'Canthatch' suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-s...

journal_title：Nature communications

authors： Hiebert CW,Moscou MJ,Hewitt T,Steuernagel B,Hernández-Pinzón I,Green P,Pujol V,Zhang P,Rouse MN,Jin Y,McIntosh RA,Upadhyaya N,Zhang J,Bhavani S,Vrána J,Karafiátová M,Huang L,Fetch T,Doležel J,Wulff BBH,Lagudah E,

更新日期：2020-02-28 00:00:00

abstract：:HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investi...

journal_title：Nature communications

authors： Huang KH,Bonsall D,Katzourakis A,Thomson EC,Fidler SJ,Main J,Muir D,Weber JN,Frater AJ,Phillips RE,Pybus OG,Goulder PJ,McClure MO,Cooke GS,Klenerman P

更新日期：2010-10-19 00:00:00

abstract：:Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto t...

journal_title：Nature communications

authors： Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD

更新日期：2018-09-07 00:00:00

abstract：:Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-...

journal_title：Nature communications

authors： Yao Y,Chen ZL,Norris EH,Strickland S

更新日期：2014-03-03 00:00:00

abstract：:Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and overlapping genetic variance. Here we perform a genome-wide association study in an ethnically homogeneous cohort of 904 schizophrenia cases and 1,640 controls drawn from the Ashkenazi Jewish population. We identify a novel g...

journal_title：Nature communications

authors： Lencz T,Guha S,Liu C,Rosenfeld J,Mukherjee S,DeRosse P,John M,Cheng L,Zhang C,Badner JA,Ikeda M,Iwata N,Cichon S,Rietschel M,Nöthen MM,Cheng AT,Hodgkinson C,Yuan Q,Kane JM,Lee AT,Pisanté A,Gregersen PK,Pe'er I

更新日期：2013-01-01 00:00:00

abstract：:Selective thermal emission in a useful range of energies from a material operating at high temperatures is required for effective solar thermophotovoltaic energy conversion. Three-dimensional metallic photonic crystals can exhibit spectral emissivity that is modified compared with the emissivity of unstructured metals...

journal_title：Nature communications

authors： Arpin KA,Losego MD,Cloud AN,Ning H,Mallek J,Sergeant NP,Zhu L,Yu Z,Kalanyan B,Parsons GN,Girolami GS,Abelson JR,Fan S,Braun PV

更新日期：2013-01-01 00:00:00

abstract：:Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...

journal_title：Nature communications

authors： Zhang Y,Huo Z,Wang X,Han X,Wu W,Wan B,Wang H,Zhai J,Tao J,Pan C,Wang ZL

更新日期：2020-11-06 00:00:00

abstract：:Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for analyzing the chemical composition and molecular structure of materials. At the nanometer scale, NMR has the prospect of mapping the atomic-scale structure of individual molecules, provided a method that can sensitively detect single nuclei and mea...

journal_title：Nature communications

authors： Zopes J,Cujia KS,Sasaki K,Boss JM,Itoh KM,Degen CL

更新日期：2018-11-08 00:00:00

abstract：:In social species, the phenotype and fitness of an individual depend in part on the genotype of its social partners. However, how these indirect genetic effects affect genotype fitness in competitive situations is poorly understood in animal societies. We therefore studied phenotypic plasticity and fitness of two clon...

journal_title：Nature communications

authors： Teseo S,Châline N,Jaisson P,Kronauer DJ

更新日期：2014-01-01 00:00:00

abstract：:We developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of which are spatially aligned and scaled according to the animal's weight, and hence provide...

journal_title：Nature communications

authors： Klose AD,Paragas N

更新日期：2018-10-15 00:00:00

abstract：:The restricted availability, expense and toxicity of precious metal catalysts such as rhodium and palladium challenge the sustainability of synthetic chemistry. As such, nickel catalysts have garnered increasing attention as replacements for enyne cyclization reactions. On the other hand, bridged tricyclo[5.2.1.01,5]d...

journal_title：Nature communications

authors： Chen J,Wang Y,Ding Z,Kong W

更新日期：2020-04-20 00:00:00

abstract：:Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We...

journal_title：Nature communications

authors： Zhao LH,Liu X,Yan HX,Li WY,Zeng X,Yang Y,Zhao J,Liu SP,Zhuang XH,Lin C,Qin CJ,Zhao Y,Pan ZY,Huang G,Liu H,Zhang J,Wang RY,Yang Y,Wen W,Lv GS,Zhang HL,Wu H,Huang S,Wang MD,Tang L,Cao HZ,Wang L,Lee TL

更新日期：2016-10-05 00:00:00

abstract：:Even as the study of plant genomics rapidly develops through the use of high-throughput sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-throughput rice phenotyping facility (HRPF) to monitor 13 traditional agronomic traits and 2 newly defined traits during the rice growth p...

journal_title：Nature communications

authors： Yang W,Guo Z,Huang C,Duan L,Chen G,Jiang N,Fang W,Feng H,Xie W,Lian X,Wang G,Luo Q,Zhang Q,Liu Q,Xiong L

更新日期：2014-10-08 00:00:00

abstract：:Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 ...

journal_title：Nature communications

authors： Li H,Wu G,Fang Q,Zhang M,Hui X,Sheng B,Wu L,Bao Y,Li P,Xu A,Jia W

更新日期：2018-01-18 00:00:00

abstract：:Bright solitons are non-dispersive wave solutions, arising in a diverse range of nonlinear, one-dimensional systems, including atomic Bose-Einstein condensates with attractive interactions. In reality, cold-atom experiments can only approach the idealized one-dimensional limit necessary for the realization of true sol...

journal_title：Nature communications

authors： Marchant AL,Billam TP,Wiles TP,Yu MM,Gardiner SA,Cornish SL

更新日期：2013-01-01 00:00:00

abstract：:In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abnormalities. While lo...

journal_title：Nature communications

authors： Assaraf E,Blecher R,Heinemann-Yerushalmi L,Krief S,Carmel Vinestock R,Biton IE,Brumfeld V,Rotkopf R,Avisar E,Agar G,Zelzer E

更新日期：2020-06-23 00:00:00

abstract：:Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology ar...

journal_title：Nature communications

authors： Spaan AN,Vrieling M,Wallet P,Badiou C,Reyes-Robles T,Ohneck EA,Benito Y,de Haas CJ,Day CJ,Jennings MP,Lina G,Vandenesch F,van Kessel KP,Torres VJ,van Strijp JA,Henry T

更新日期：2014-11-11 00:00:00

abstract：:Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylas...

journal_title：Nature communications

authors： Jurado AR,Huang CS,Zhang X,Zhou ZH,Tong L

更新日期：2015-11-23 00:00:00

abstract：:Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...

journal_title：Nature communications

authors： Kehayias P,Jarmola A,Mosavian N,Fescenko I,Benito FM,Laraoui A,Smits J,Bougas L,Budker D,Neumann A,Brueck SRJ,Acosta VM

更新日期：2017-08-04 00:00:00

abstract：:Protein expression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency represents a primary determinant of protein levels during stimuli adaptation. This raises the question as to the translatome remodelers that titrate protein output from mRNA populations. Here, we uncover a net...

journal_title：Nature communications

authors： Ho JJD,Balukoff NC,Theodoridis PR,Wang M,Krieger JR,Schatz JH,Lee S

更新日期：2020-05-29 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00