Abstract：
:Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modules in the network undergoes a percolation transition, a sudden critical transition from scattered small modules to a large connected cluster, during colorectal tumorigenesis. Such a large cluster ultimately results in a giant percolated cluster, which is accompanied by phenotypic changes corresponding to cancer hallmarks. Moreover, we find that the most commonly observed sequence of driver mutations in colorectal cancer has been optimized to maximize the giant percolated cluster. Our network-level percolation study shows that the cooperative effect rather than any single dominance of multiple somatic mutations is crucial in colorectal tumorigenesis.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Shin D,Lee J,Gong JR,Cho KHdoi
10.1038/s41467-017-01171-6subject
Has Abstractpub_date
2017-11-02 00:00:00pages
1270issue
1issn
2041-1723pii
10.1038/s41467-017-01171-6journal_volume
8pub_type
杂志文章abstract：:Polymeric semiconductors are materials where unique optical and electronic properties often originate from a tailored chemical structure. This allows for synthesizing conjugated macromolecules with ad hoc functionalities for organic electronics. In photovoltaics, donor-acceptor co-polymers, with moieties of different ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1967
更新日期：2012-07-24 00:00:00
abstract：:Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear. We used slice electrophysiology to measure connectivity changes associated with song learning in the avian analog...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01914-5
更新日期：2017-12-13 00:00:00
abstract：:The ~70 km-diameter Yarrabubba impact structure in Western Australia is regarded as among Earth's oldest, but has hitherto lacked precise age constraints. Here we present U-Pb ages for impact-driven shock-recrystallised accessory minerals. Shock-recrystallised monazite yields a precise impact age of 2229 ± 5 Ma, coeva...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13985-7
更新日期：2020-01-21 00:00:00
abstract：:A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de no...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01082-6
更新日期：2017-10-19 00:00:00
abstract：:Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03937-y
更新日期：2018-04-17 00:00:00
abstract：:Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully recode, construct and characterize the biosynthetic pathway of bikaverin, a tetracyclic polyketide with antib...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19984-3
更新日期：2020-12-03 00:00:00
abstract：:Heterogeneity in transmission is a challenge for infectious disease dynamics and control. An 80-20 "Pareto" rule has been proposed to describe this heterogeneity whereby 80% of transmission is accounted for by 20% of individuals, herein called super-spreaders. It is unclear, however, whether super-spreading can be att...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11861-y
更新日期：2019-09-02 00:00:00
abstract：:Carbon forms one of nature's strongest chemical bonds; its allotropes having provided some of the most exciting scientific discoveries in recent times. The possibility of inter-allotropic transformations/hybridization of carbon is hence a topic of immense fundamental and technological interest. Such modifications usua...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5941
更新日期：2014-09-15 00:00:00
abstract：:Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDE...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7956
更新日期：2015-04-24 00:00:00
abstract：:Converting and storing solar energy and releasing it on demand by using solar flow batteries (SFBs) is a promising way to address the challenge of solar intermittency. Although high solar-to-output electricity efficiencies (SOEE) have been recently demonstrated in SFBs, the complex multi-junction photoelectrodes used ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20287-w
更新日期：2021-01-08 00:00:00
abstract：:The most explosive basaltic scoria cone eruption yet documented (>20 km high plumes) occurred at Sunset Crater (Arizona) ca. 1085 AD by undetermined eruptive mechanisms. We present melt inclusion analysis, including bubble contents by Raman spectroscopy, yielding high total CO2 (approaching 6000 ppm) and S (~2000 ppm)...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20354-2
更新日期：2021-01-11 00:00:00
abstract：:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15588-z
更新日期：2020-04-08 00:00:00
abstract：:The 2018 summit and flank eruption of Kīlauea Volcano was one of the largest volcanic events in Hawai'i in 200 years. Data suggest that a backup in the magma plumbing system at the long-lived Pu'u 'Ō'ō eruption site caused widespread pressurization in the volcano, driving magma into the lower flank. The eruption evolv...
journal_title：Nature communications
pub_type： 杂志文章,评审
doi：10.1038/s41467-020-19190-1
更新日期：2020-11-06 00:00:00
abstract：:Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms that prevent transcriptional interference are not well understood. Here ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12328-w
更新日期：2019-09-25 00:00:00
abstract：:Neurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form of axonal remodelling alters brain functional structure remains unclear. To understand how collateral sprouting proceeds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibre...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12938
更新日期：2016-09-21 00:00:00
abstract：:The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surpr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02651-5
更新日期：2018-01-09 00:00:00
abstract：:Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Salmonellae and Mycobacterium tuberculosis (Mtb) exploit host pathways t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02777-6
更新日期：2018-01-24 00:00:00
abstract：:Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels is a promising therapeutic f...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11992
更新日期：2016-06-30 00:00:00
abstract：:The original version of this Article contained an error in the spelling of the author Woochul Song, which was incorrectly given as Woochul C. Song. This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-05447-3
更新日期：2018-08-14 00:00:00
abstract：:Despite the increasing resolution, forcing on the mean circulation by resolved waves in general circulation models is not yet converging. Parameterization of the forcing remains a major source of model uncertainty. This study examines the scale invariance of zonal spectra of momentum flux and wave forcing, and shows t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10527-z
更新日期：2019-06-13 00:00:00
abstract：:Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the Uniform Manifold Approximation and Projection (UMAP) method on published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae. Proximity in low-dimensional UMAP space identifies groups of ge...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15351-4
更新日期：2020-03-24 00:00:00
abstract：:COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18709-w
更新日期：2020-10-07 00:00:00
abstract：:Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury, or tumor, is key to an appropriately targeted immune response. Pathogen detection is increasingly well defined mechanistically, but the discrimination of endogenous inflammatory triggers remains unclear. ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01718-7
更新日期：2017-11-17 00:00:00
abstract：:Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowin...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08433-5
更新日期：2019-02-01 00:00:00
abstract：:The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, an...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5569
更新日期：2014-08-05 00:00:00
abstract：:Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05202-8
更新日期：2018-08-22 00:00:00
abstract：:Protein glycosylation is ubiquitous in biological systems and essential for cell survival. However, the heterogeneity of glycans and the low abundance of many glycoproteins complicate their global analysis. Chemical methods based on reversible covalent interactions between boronic acid and glycans have great potential...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04081-3
更新日期：2018-04-27 00:00:00
abstract：:Ubiquitin-like (Ubl) modifications regulate nearly all cellular functions in eukaryotes with the largest superfamily of Ubl-specific proteases being Cys proteases. SENP1 is a model for this protease family and responsible for processing SUMO. Here using nuclear magnetic resonance relaxation measurements, chemical shif...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5968
更新日期：2014-09-29 00:00:00
abstract：:During morphogenesis, remodelling of cell shape requires the expansion or contraction of plasma membrane domains. Here we identify a mechanism underlying the restructuring of the apical surface during epithelial morphogenesis in Drosophila. We show that the retraction of villous protrusions and subsequent apical plasm...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3244
更新日期：2013-01-01 00:00:00
abstract：:TFIIS-like transcript cleavage factors enhance the processivity and fidelity of archaeal and eukaryotic RNA polymerases. Sulfolobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved into a potent RNA polymerase inhibitor. TFS4 destabilises the TBP-TFB-RNAP pre-initiation com...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02081-3
更新日期：2017-12-04 00:00:00
