BORDER proteins protect expression of neighboring genes by promoting 3' Pol II pausing in plants.

abstract：:Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylas...

journal_title：Nature communications

authors： Jurado AR,Huang CS,Zhang X,Zhou ZH,Tong L

更新日期：2015-11-23 00:00:00

abstract：:Chloroplasts communicate information by signalling to nuclei during acclimation to fluctuating light. Several potential operating signals originating from chloroplasts have been proposed, but none have been shown to move to nuclei to modulate gene expression. One proposed signal is hydrogen peroxide (H2O2) produced by...

journal_title：Nature communications

authors： Exposito-Rodriguez M,Laissue PP,Yvon-Durocher G,Smirnoff N,Mullineaux PM

更新日期：2017-06-29 00:00:00

abstract：:Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information proces...

journal_title：Nature communications

authors： Moore S,Meschkat M,Ruhwedel T,Trevisiol A,Tzvetanova ID,Battefeld A,Kusch K,Kole MHP,Strenzke N,Möbius W,de Hoz L,Nave KA

更新日期：2020-10-30 00:00:00

abstract：:[This corrects the article DOI: 10.1038/ncomms5802.]. ...

journal_title：Nature communications

authors： Rakheja D,Chen KS,Liu Y,Shukla AA,Schmid V,Chang TC,Khokhar S,Wickiser JE,Karandikar NJ,Malter JS,Mendell JT,Amatruda JF

更新日期：2017-11-29 00:00:00

abstract：:Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposo...

journal_title：Nature communications

authors： Shen J,Liu J,Xie K,Xing F,Xiong F,Xiao J,Li X,Xiong L

更新日期：2017-03-03 00:00:00

abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...

journal_title：Nature communications

authors： Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ez

更新日期：2018-02-02 00:00:00

abstract：:While molecular water-oxidation catalysts are remarkably rapid, oxidative and hydrolytic processes in water can convert their active transition metals to colloidal metal oxides or hydroxides that, while quite reactive, are insoluble or susceptible to precipitation. In response, we propose using oxidatively-inert ligan...

journal_title：Nature communications

authors： Chakraborty B,Gan-Or G,Raula M,Gadot E,Weinstock IA

更新日期：2018-11-20 00:00:00

abstract：:Large-scale genomic data highlight the complexity and diversity of the molecular changes that drive cancer progression. Statistical analysis of cancer data from different tissues can guide drug repositioning as well as the design of targeted treatments. Here, we develop an improved Bayesian network model for tumour mu...

journal_title：Nature communications

authors： Kuipers J,Thurnherr T,Moffa G,Suter P,Behr J,Goosen R,Christofori G,Beerenwinkel N

更新日期：2018-10-19 00:00:00

abstract：:Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully recode, construct and characterize the biosynthetic pathway of bikaverin, a tetracyclic polyketide with antib...

journal_title：Nature communications

authors： Zhao M,Zhao Y,Yao M,Iqbal H,Hu Q,Liu H,Qiao B,Li C,Skovbjerg CAS,Nielsen JC,Nielsen J,Frandsen RJN,Yuan Y,Boeke JD

更新日期：2020-12-03 00:00:00

abstract：:The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical cha...

journal_title：Nature communications

authors： Liang W,Yao J,Chen A,Lv Q,Zanin M,Liu J,Wong S,Li Y,Lu J,Liang H,Chen G,Guo H,Guo J,Zhou R,Ou L,Zhou N,Chen H,Yang F,Han X,Huan W,Tang W,Guan W,Chen Z,Zhao Y,Sang L,Xu Y,Wang W,Li S,Lu L,Zhang N

更新日期：2020-07-15 00:00:00

abstract：:Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regard...

journal_title：Nature communications

authors： Cao H,Chén OY,Chung Y,Forsyth JK,McEwen SC,Gee DG,Bearden CE,Addington J,Goodyear B,Cadenhead KS,Mirzakhanian H,Cornblatt BA,Carrión RE,Mathalon DH,McGlashan TH,Perkins DO,Belger A,Seidman LJ,Thermenos H,Tsuang MT,

更新日期：2018-09-21 00:00:00

abstract：:The human brain is inherently limited in the information it can make consciously accessible. When people monitor a rapid stream of visual items for two targets, they typically fail to see the second target if it occurs within 200-500 ms of the first, a phenomenon called the attentional blink (AB). The neural basis for...

journal_title：Nature communications

authors： Tang MF,Ford L,Arabzadeh E,Enns JT,Visser TAW,Mattingley JB

更新日期：2020-01-23 00:00:00

abstract：:Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate macrophage activation. In primary macrophages, PARP9 and PARP14 have o...

journal_title：Nature communications

authors： Iwata H,Goettsch C,Sharma A,Ricchiuto P,Goh WW,Halu A,Yamada I,Yoshida H,Hara T,Wei M,Inoue N,Fukuda D,Mojcher A,Mattson PC,Barabási AL,Boothby M,Aikawa E,Singh SA,Aikawa M

更新日期：2016-10-31 00:00:00

abstract：:Synapse degeneration is an early and invariant feature of neurodegenerative diseases. Indeed, synapse loss occurs prior to neuronal degeneration and correlates with the symptom severity of these diseases. However, the molecular mechanisms that trigger synaptic loss remain poorly understood. Here we demonstrate that de...

journal_title：Nature communications

authors： Galli S,Lopes DM,Ammari R,Kopra J,Millar SE,Gibb A,Salinas PC

更新日期：2014-10-16 00:00:00

abstract：:The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...

journal_title：Nature communications

authors： Cacheiro P,Muñoz-Fuentes V,Murray SA,Dickinson ME,Bucan M,Nutter LMJ,Peterson KA,Haselimashhadi H,Flenniken AM,Morgan H,Westerberg H,Konopka T,Hsu CW,Christiansen A,Lanza DG,Beaudet AL,Heaney JD,Fuchs H,Gailus-Durner

更新日期：2020-01-31 00:00:00

abstract：:Chromatin looping allows enhancer-bound regulatory factors to influence transcription. Large domains, referred to as topologically associated domains, participate in genome organization. However, the mechanisms underlining interactions within these domains, which control gene expression, are not fully understood. Here...

journal_title：Nature communications

authors： Magli A,Baik J,Pota P,Cordero CO,Kwak IY,Garry DJ,Love PE,Dynlacht BD,Perlingeiro RCR

更新日期：2019-05-24 00:00:00

abstract：:It is vital to design effective nitrogen fixation systems that operate under mild conditions, and to this end we recently reported an example of the catalytic formation of ammonia using a dinitrogen-bridged dimolybdenum complex bearing a pincer ligand, where up to twenty three equivalents of ammonia were produced base...

journal_title：Nature communications

authors： Tanaka H,Arashiba K,Kuriyama S,Sasada A,Nakajima K,Yoshizawa K,Nishibayashi Y

更新日期：2014-04-28 00:00:00

abstract：:The Johnson-Kendall-Roberts theory is the basis of modern contact mechanics. It describes how two deformable objects adhere together, driven by adhesion energy and opposed by elasticity. Here we characterize the indentation of glass particles into soft, silicone substrates using confocal microscopy. We show that, wher...

journal_title：Nature communications

authors： Style RW,Hyland C,Boltyanskiy R,Wettlaufer JS,Dufresne ER

更新日期：2013-01-01 00:00:00

abstract：:How electronic charge is distributed over a molecule determines to a large extent its chemical properties. Here, we demonstrate how the electrostatic force field, originating from the inhomogeneous charge distribution in a molecule, can be measured with submolecular resolution. We exploit the fact that distortions typ...

journal_title：Nature communications

authors： Hapala P,Švec M,Stetsovych O,van der Heijden NJ,Ondráček M,van der Lit J,Mutombo P,Swart I,Jelínek P

更新日期：2016-05-27 00:00:00

abstract：:Topological nodal line semimetals, a novel quantum state of materials, possess topologically nontrivial valence and conduction bands that touch at a line near the Fermi level. The exotic band structure can lead to various novel properties, such as long-range Coulomb interaction and flat Landau levels. Recently, topolo...

journal_title：Nature communications

authors： Feng B,Fu B,Kasamatsu S,Ito S,Cheng P,Liu CC,Feng Y,Wu S,Mahatha SK,Sheverdyaeva P,Moras P,Arita M,Sugino O,Chiang TC,Shimada K,Miyamoto K,Okuda T,Wu K,Chen L,Yao Y,Matsuda I

更新日期：2017-10-18 00:00:00

abstract：:Mesa structures made of Bi2Sr2CaCu2O8+δ high-temperature superconductor represent stacks of atomic scale intrinsic Josephson junctions. They can be used for generation of high-frequency electromagnetic waves. Here we analyze Josephson emission from small-but-high mesas (with a small area, but containing many stacked j...

journal_title：Nature communications

authors： Borodianskyi EA,Krasnov VM

更新日期：2017-11-23 00:00:00

abstract：:Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncy...

journal_title：Nature communications

authors： Ezzat K,Pernemalm M,Pålsson S,Roberts TC,Järver P,Dondalska A,Bestas B,Sobkowiak MJ,Levänen B,Sköld M,Thompson EA,Saher O,Kari OK,Lajunen T,Sverremark Ekström E,Nilsson C,Ishchenko Y,Malm T,Wood MJA,Power UF,Masic

更新日期：2019-05-27 00:00:00

abstract：:The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...

journal_title：Nature communications

authors： Gersch M,Famulla K,Dahmen M,Göbl C,Malik I,Richter K,Korotkov VS,Sass P,Rübsamen-Schaeff H,Madl T,Brötz-Oesterhelt H,Sieber SA

更新日期：2015-02-19 00:00:00

abstract：:Supported gold (Au) nanocatalysts have attracted extensive interests in the past decades because of their unique catalytic properties for a number of key chemical reactions, especially in (selective) oxidations. The activation of O2 on Au nanocatalysts is crucial and remains a challenge because only small Au nanoparti...

journal_title：Nature communications

authors： Zhang Y,Zhang J,Zhang B,Si R,Han B,Hong F,Niu Y,Sun L,Li L,Qiao B,Sun K,Huang J,Haruta M

更新日期：2020-01-28 00:00:00

abstract：:Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymerize outward from adhesion sites to push membranes towards distant sit...

journal_title：Nature communications

authors： Garbett D,Bisaria A,Yang C,McCarthy DG,Hayer A,Moerner WE,Svitkina TM,Meyer T

更新日期：2020-09-23 00:00:00

abstract：:Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation o...

journal_title：Nature communications

authors： Nishio N,van den Berg NS,van Keulen S,Martin BA,Fakurnejad S,Teraphongphom N,Chirita SU,Oberhelman NJ,Lu G,Horton CE,Kaplan MJ,Divi V,Colevas AD,Rosenthal EL

更新日期：2019-11-06 00:00:00

abstract：:The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enrich...

journal_title：Nature communications

authors： Pers TH,Karjalainen JM,Chan Y,Westra HJ,Wood AR,Yang J,Lui JC,Vedantam S,Gustafsson S,Esko T,Frayling T,Speliotes EK,Genetic Investigation of ANthropometric Traits (GIANT) Consortium.,Boehnke M,Raychaudhuri S,Fehrmann RS,

更新日期：2015-01-19 00:00:00

abstract：:It has been observed that concentrated solutions of short DNA oligomers develop liquid crystal ordering as the result of a hierarchically structured supramolecular self-assembly. In mixtures of oligomers with various degree of complementarity, liquid crystal microdomains are formed via the selective aggregation of tho...

journal_title：Nature communications

authors： Fraccia TP,Smith GP,Zanchetta G,Paraboschi E,Yi Y,Walba DM,Dieci G,Clark NA,Bellini T

更新日期：2015-03-10 00:00:00

abstract：:Alternative splicing and alternative polyadenylation (APA) of pre-mRNAs greatly contribute to transcriptome diversity, coding capacity of a genome and gene regulatory mechanisms in eukaryotes. Second-generation sequencing technologies have been extensively used to analyse transcriptomes. However, a major limitation of...

journal_title：Nature communications

authors： Abdel-Ghany SE,Hamilton M,Jacobi JL,Ngam P,Devitt N,Schilkey F,Ben-Hur A,Reddy AS

更新日期：2016-06-24 00:00:00

abstract：:5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate that p53 promotes WNT3 transcription, leading to activation of the WNT/...

journal_title：Nature communications

authors： Cho YH,Ro EJ,Yoon JS,Mizutani T,Kang DW,Park JC,Il Kim T,Clevers H,Choi KY

更新日期：2020-10-21 00:00:00