Abstract:
:[This corrects the article DOI: 10.1038/ncomms5802.].
journal_name
Nat Communjournal_title
Nature communicationsauthors
Rakheja D,Chen KS,Liu Y,Shukla AA,Schmid V,Chang TC,Khokhar S,Wickiser JE,Karandikar NJ,Malter JS,Mendell JT,Amatruda JFdoi
10.1038/ncomms16177subject
Has Abstractpub_date
2017-11-29 00:00:00pages
16177issn
2041-1723journal_volume
8pub_type
已发布勘误abstract::Martensitic transition is a solid-state phase transition involving cooperative movement of atoms, mostly studied in metallurgy. The main characteristics are low transition barrier, ultrafast kinetics, and structural reversibility. They are rarely observed in molecular crystals, and hence the origin and mechanism are l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02607-9
更新日期:2018-01-18 00:00:00
abstract::The formation of the HIV-1 core is the final step in the viral maturation pathway, resulting in the formation of infectious virus. Most current models for HIV-1 core formation suggest that, upon proteolytic cleavage from the immature Gag, capsid (CA) dissociates into the viral interior before reforming into the core. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6854
更新日期:2015-01-08 00:00:00
abstract::Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09451-z
更新日期:2019-03-29 00:00:00
abstract::Momentum and spin represent fundamental dynamic properties of quantum particles and fields. In particular, propagating optical waves (photons) carry momentum and longitudinal spin determined by the wave vector and circular polarization, respectively. Here we show that exactly the opposite can be the case for evanescen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4300
更新日期:2014-03-06 00:00:00
abstract::Third generation sequencing technologies provide the opportunity to improve genome assemblies by generating long reads spanning most repeat sequences. However, current analysis methods require substantial amounts of sequence data and computational resources to overcome the high error rates. Furthermore, they can only ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14515
更新日期:2017-02-20 00:00:00
abstract::Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. We find that Slc44a2 null mic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17254-w
更新日期:2020-07-13 00:00:00
abstract::MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12970
更新日期:2016-09-27 00:00:00
abstract::Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of the kidney remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic and structural heterogeneity of the kidney vasculature are unknown. Here, we employ high-throughput bulk and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12872-5
更新日期:2019-12-13 00:00:00
abstract::Transcription of eukaryotic protein-coding genes requires passage of RNA polymerase II (Pol II) through nucleosomes, but it is unclear how this is achieved. Here we report the cryo-EM structure of transcribing Saccharomyces cerevisiae Pol II engaged with a downstream nucleosome core particle at an overall resolution o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07870-y
更新日期:2018-12-21 00:00:00
abstract::The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04295-5
更新日期:2018-05-15 00:00:00
abstract::Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against bioactive small molecules. We identify Milciclib that blocks glucose cons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13334-8
更新日期:2019-11-29 00:00:00
abstract::The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-19045-9
更新日期:2020-10-16 00:00:00
abstract::There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11039-6
更新日期:2019-07-10 00:00:00
abstract::Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16350-1
更新日期:2020-05-15 00:00:00
abstract::The breast cancer susceptibility gene BRCA1 is well known for its function in double-strand break (DSB) DNA repair. While BRCA1 is also implicated in transcriptional regulation, the physiological significance remains unclear. COBRA1 (also known as NELF-B) is a BRCA1-binding protein that regulates RNA polymerase II (RN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10913
更新日期:2016-03-04 00:00:00
abstract::Nanocrystal quantum dots are attractive materials for applications as nanoscale light sources. One impediment to these applications is fluctuations of single-dot emission intensity, known as blinking. Recent progress in colloidal synthesis has produced nonblinking nanocrystals; however, the physics underlying blinking...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1916
更新日期:2012-06-19 00:00:00
abstract::NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but have not been functionally evaluated. Here we use evolutionary conservation analysis to build a model structure of NHE9 based on the crystal structu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3510
更新日期:2013-01-01 00:00:00
abstract::The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis suppressor TAp63, a p53 family member. By performing a mouse-human cross...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18973-w
更新日期:2020-10-14 00:00:00
abstract::High-angle grain boundaries are always the preferential fatigue cracking sites, while the intrinsic fatigue cracking mechanism of coherent twin boundary remains elusive. Here we systematically investigate the fatigue cracking behaviours of copper bicrystals with a coherent twin boundary as their sole internal boundary...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4536
更新日期:2014-03-26 00:00:00
abstract::Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of v...
journal_title:Nature communications
pub_type: 临床试验,杂志文章
doi:10.1038/s41467-018-04591-0
更新日期:2018-06-18 00:00:00
abstract::Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca(2+) blocks intercellular communication during tissue injury, we determined the X-ray crystal structures of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9770
更新日期:2016-01-12 00:00:00
abstract::Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globally DHX36 binding to ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10432-5
更新日期:2019-06-03 00:00:00
abstract::DNA is a promising molecule for applications in molecular electronics because of its unique electronic and self-assembly properties. Here we report that the conductance of DNA duplexes increases by approximately one order of magnitude when its conformation is changed from the B-form to the A-form. This large conductan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9870
更新日期:2015-12-09 00:00:00
abstract::Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here we find that junctional adh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9128
更新日期:2015-08-26 00:00:00
abstract::Microalbuminuria is an important clinical marker of several cardiovascular, metabolic, and other diseases such as diabetes, hypertension, atherosclerosis, and cancer. The accurate detection of microalbuminuria relies on albumin quantification in the urine, usually via an immunoturbidity assay; however, like many antib...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11583-1
更新日期:2019-08-09 00:00:00
abstract::Surface and subsurface are commonly considered as separate entities because of the difference in the bonding environment and are often investigated separately due to the experimental challenges in differentiating the surface and subsurface effects. Using in-situ atomic-scale transmission electron microscopy to resolve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14167-1
更新日期:2020-01-16 00:00:00
abstract::Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylatio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8679
更新日期:2015-07-09 00:00:00
abstract::Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. Recently, the little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) gene...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6941
更新日期:2015-01-09 00:00:00
abstract::ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a synthetic lethal interaction with aurora kinase A (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05694-4
更新日期:2018-08-10 00:00:00
abstract::Multiciliated ependymal (E1) cells line the brain ventricles and are essential for brain homeostasis. We previously identified in the lateral ventricles a rare ependymal subpopulation (E2) with only two cilia and unique basal bodies. Here we show that E2 cells form a distinct biciliated epithelium extending along the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13759
更新日期:2017-01-09 00:00:00