当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > A role of oligodendrocytes in information processing.

A role of oligodendrocytes in information processing.

Abstract：

:Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information processing in addition to speeding up conduction velocity. Here, we analyze the role of myelin in auditory information processing using paradigms that are also good predictors of speech understanding in humans. We compare mice with different degrees of dysmyelination using acute multiunit recordings in the auditory cortex, in combination with behavioral readouts. We find complex alterations of neuronal responses that reflect fatigue and temporal acuity deficits. We observe partially discriminable but similar deficits in well myelinated mice in which glial cells cannot fully support axons metabolically. We suggest a model in which myelination contributes to sustained stimulus perception in temporally complex paradigms, with a role of metabolically active oligodendrocytes in cortical information processing.

journal_name

Nat Commun

journal_title

Nature communications

authors

Moore S,Meschkat M,Ruhwedel T,Trevisiol A,Tzvetanova ID,Battefeld A,Kusch K,Kole MHP,Strenzke N,Möbius W,de Hoz L,Nave KA

doi

10.1038/s41467-020-19152-7

subject

Has Abstract

pub_date

2020-10-30 00:00:00

pages

5497

issue

1

issn

2041-1723

pii

10.1038/s41467-020-19152-7

journal_volume

11

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions.

    abstract：:The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental overexpression of TRF2 ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10132

    authors： Nera B,Huang HS,Lai T,Xu L

    更新日期：2015-12-07 00:00:00

  • Synthesis of sodium polyhydrides at high pressures.

    abstract：:The only known compound of sodium and hydrogen is archetypal ionic NaH. Application of high pressure is known to promote states with higher atomic coordination, but extensive searches for polyhydrides with unusual stoichiometry have had only limited success in spite of several theoretical predictions. Here we report t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12267

    authors： Struzhkin VV,Kim DY,Stavrou E,Muramatsu T,Mao HK,Pickard CJ,Needs RJ,Prakapenka VB,Goncharov AF

    更新日期：2016-07-28 00:00:00

  • Quantum vertex model for reversible classical computing.

    abstract：:Mappings of classical computation onto statistical mechanics models have led to remarkable successes in addressing some complex computational problems. However, such mappings display thermodynamic phase transitions that may prevent reaching solution even for easy problems known to be solvable in polynomial time. Here ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15303

    authors： Chamon C,Mucciolo ER,Ruckenstein AE,Yang ZC

    更新日期：2017-05-12 00:00:00

  • Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity.

    abstract：:Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize fitness of all traits leading to a "master of all traits". The shape of trade-offs has been shown to determine evolutionary trajectories and is often assumed to be static and independent of the actual evolutionary process. Her...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01957-8

    authors： Huang W,Traulsen A,Werner B,Hiltunen T,Becks L

    更新日期：2017-12-12 00:00:00

  • Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae.

    abstract：:Microbial production of isoprene from renewable feedstock is a promising alternative to traditional petroleum-based processes. Currently, efforts to improve isoprenoid production in Saccharomyces cerevisiae mainly focus on cytoplasmic engineering, whereas comprehensive engineering of multiple subcellular compartments ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12851

    authors： Lv X,Wang F,Zhou P,Ye L,Xie W,Xu H,Yu H

    更新日期：2016-09-21 00:00:00

  • Nanoelectromechanical coupling in fullerene peapods probed by resonant electrical transport experiments.

    abstract：:Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1034

    authors： Utko P,Ferone R,Krive IV,Shekhter RI,Jonson M,Monthioux M,Noé L,Nygård J

    更新日期：2010-07-13 00:00:00

  • Mnemonic prediction errors bias hippocampal states.

    abstract：:When our experience violates our predictions, it is adaptive to upregulate encoding of novel information, while down-weighting retrieval of erroneous memory predictions to promote an updated representation of the world. We asked whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17287-1

    authors： Bein O,Duncan K,Davachi L

    更新日期：2020-07-10 00:00:00

  • Non-conventional mechanism of ferroelectric fatigue via cation migration.

    abstract：:The unique properties of ferroelectric materials enable a plethora of applications, which are hindered by the phenomenon known as ferroelectric fatigue that leads to the degradation of ferroelectric properties with polarization cycling. Multiple microscopic models explaining fatigue have been suggested; however, the c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11089-w

    authors： Ievlev AV,Kc S,Vasudevan RK,Kim Y,Lu X,Alexe M,Cooper VR,Kalinin SV,Ovchinnikova OS

    更新日期：2019-07-11 00:00:00

  • The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission.

    abstract：:Assessing the physical connections and allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challenging, with few crystal structures available to show their overall structural organizations. Here we report the quaternary architecture of multi-domain retinoic acid receptor β-retinoi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00981-y

    authors： Chandra V,Wu D,Li S,Potluri N,Kim Y,Rastinejad F

    更新日期：2017-10-11 00:00:00

  • Superconducting phase diagram of H3S under high magnetic fields.

    abstract：:The discovery of superconductivity at 260 K in hydrogen-rich compounds like LaH10 re-invigorated the quest for room temperature superconductivity. Here, we report the temperature dependence of the upper critical fields μ0Hc2(T) of superconducting H3S under a record-high combination of applied pressures up to 160 GPa a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10552-y

    authors： Mozaffari S,Sun D,Minkov VS,Drozdov AP,Knyazev D,Betts JB,Einaga M,Shimizu K,Eremets MI,Balicas L,Balakirev FF

    更新日期：2019-06-07 00:00:00

  • Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.

    abstract：:The high Aβ42/Aβ40 production ratio is a hallmark of familial Alzheimer's disease, which can be caused by mutations in the amyloid precursor protein (APP). The C-terminus of Aβ is generated by γ-secretase cleavage within the transmembrane domain of APP (APPTM), a process that is primed by an initial ε-cleavage at eith...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4037

    authors： Chen W,Gamache E,Rosenman DJ,Xie J,Lopez MM,Li YM,Wang C

    更新日期：2014-01-01 00:00:00

  • Towards a new approach to reveal dynamical organization of the brain using topological data analysis.

    abstract：:Little is known about how our brains dynamically adapt for efficient functioning. Most previous work has focused on analyzing changes in co-fluctuations between a set of brain regions over several temporal segments of the data. We argue that by collapsing data in space or time, we stand to lose useful information abou...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03664-4

    authors： Saggar M,Sporns O,Gonzalez-Castillo J,Bandettini PA,Carlsson G,Glover G,Reiss AL

    更新日期：2018-04-11 00:00:00

  • Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen.

    abstract：:Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17094-8

    authors： Mika-Gospodorz B,Giengkam S,Westermann AJ,Wongsantichon J,Kion-Crosby W,Chuenklin S,Wang LC,Sunyakumthorn P,Sobota RM,Subbian S,Vogel J,Barquist L,Salje J

    更新日期：2020-07-03 00:00:00

  • Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.

    abstract：:Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9009

    authors： Muthana M,Kennerley AJ,Hughes R,Fagnano E,Richardson J,Paul M,Murdoch C,Wright F,Payne C,Lythgoe MF,Farrow N,Dobson J,Conner J,Wild JM,Lewis C

    更新日期：2015-08-18 00:00:00

  • Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation.

    abstract：:Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13554-y

    authors： Hasegawa S,Fukushima H,Hosoda H,Serita T,Ishikawa R,Rokukawa T,Kawahara-Miki R,Zhang Y,Ohta M,Okada S,Tanimizu T,Josselyn SA,Frankland PW,Kida S

    更新日期：2019-12-18 00:00:00

  • Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron.

    abstract：:Foldamers provide an attractive medium to test the mechanisms by which biological macromolecules fold into complex three-dimensional structures, and ultimately to design novel protein-like architectures with properties unprecedented in nature. Here, we describe a large cage-like structure formed from an amphiphilic ar...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4581

    authors： Pavone V,Zhang SQ,Merlino A,Lombardi A,Wu Y,DeGrado WF

    更新日期：2014-04-07 00:00:00

  • Interface control of the magnetic chirality in CoFeB/MgO heterostructures with heavy-metal underlayers.

    abstract：:Recent advances in the understanding of spin orbital effects in ultrathin magnetic heterostructures have opened new paradigms to control magnetic moments electrically. The Dzyaloshinskii-Moriya interaction (DMI) is said to play a key role in forming a Néel-type domain wall that can be driven by the spin Hall torque. H...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5655

    authors： Torrejon J,Kim J,Sinha J,Mitani S,Hayashi M,Yamanouchi M,Ohno H

    更新日期：2014-08-18 00:00:00

  • Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.

    abstract：:Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10944

    authors： Nakamura S,Karalay Ö,Jäger PS,Horikawa M,Klein C,Nakamura K,Latza C,Templer SE,Dieterich C,Antebi A

    更新日期：2016-03-22 00:00:00

  • Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1.

    abstract：:Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pa...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6736

    authors： Fusi C,Materazzi S,Benemei S,Coppi E,Trevisan G,Marone IM,Minocci D,De Logu F,Tuccinardi T,Di Tommaso MR,Susini T,Moneti G,Pieraccini G,Geppetti P,Nassini R

    更新日期：2014-12-08 00:00:00

  • Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.

    abstract：:In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch--two central cell fate events--take place in the G1 phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G1/S transition, whose major regulatory feature is multisite ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11372

    authors： Palumbo P,Vanoni M,Cusimano V,Busti S,Marano F,Manes C,Alberghina L

    更新日期：2016-04-20 00:00:00

  • Resolving Dirac electrons with broadband high-resolution NMR.

    abstract：:Detecting the metallic Dirac electronic states on the surface of Topological Insulators (TIs) is critical for the study of important surface quantum properties (SQPs), such as Majorana zero modes, where simultaneous probing of the bulk and edge electron states is required. However, there is a particular shortage of ex...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14838-4

    authors： Papawassiliou W,Jaworski A,Pell AJ,Jang JH,Kim Y,Lee SC,Kim HJ,Alwahedi Y,Alhassan S,Subrati A,Fardis M,Karagianni M,Panopoulos N,Dolinšek J,Papavassiliou G

    更新日期：2020-03-09 00:00:00

  • Solution nuclear magnetic resonance spectroscopy on a nanostructured diamond chip.

    abstract：:Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00266-4

    authors： Kehayias P,Jarmola A,Mosavian N,Fescenko I,Benito FM,Laraoui A,Smits J,Bougas L,Budker D,Neumann A,Brueck SRJ,Acosta VM

    更新日期：2017-08-04 00:00:00

  • A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages.

    abstract：:We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-generational lineage tracking under controlled culture conditions. We use this platform to generate whole-transcriptome profiles of primary, activated murine CD8+ T-cell and lymphocytic leukemia cell line lineages. Here we repor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10220

    authors： Kimmerling RJ,Lee Szeto G,Li JW,Genshaft AS,Kazer SW,Payer KR,de Riba Borrajo J,Blainey PC,Irvine DJ,Shalek AK,Manalis SR

    更新日期：2016-01-06 00:00:00

  • A synthetic microbial biosensor for high-throughput screening of lactam biocatalysts.

    abstract：:Biocatalytic cyclization is highly desirable for efficient synthesis of biologically derived chemical substances, such as the commodity chemicals ε-caprolactam and δ-valerolactam. To identify biocatalysts in lactam biosynthesis, we develop a caprolactam-detecting genetic enzyme screening system (CL-GESS). The Alcalige...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07488-0

    authors： Yeom SJ,Kim M,Kwon KK,Fu Y,Rha E,Park SH,Lee H,Kim H,Lee DH,Kim DM,Lee SG

    更新日期：2018-11-29 00:00:00

  • Observation of topological transport quantization by dissipation in fast Thouless pumps.

    abstract：:Quantized dynamics is essential for natural processes and technological applications alike. The work of Thouless on quantized particle transport in slowly varying potentials (Thouless pumping) has played a key role in understanding that such quantization may be caused not only by discrete eigenvalues of a quantum syst...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17510-z

    authors： Fedorova Z,Qiu H,Linden S,Kroha J

    更新日期：2020-07-27 00:00:00

  • miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.

    abstract：:HOXA9 and MEIS1 have essential oncogenic roles in mixed lineage leukaemia (MLL)-rearranged leukaemia. Here we show that they are direct targets of miRNA-196b, a microRNA (miRNA) located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells. Forced expression of miR-196b significantly delays MLL-fu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1681

    authors： Li Z,Huang H,Chen P,He M,Li Y,Arnovitz S,Jiang X,He C,Hyjek E,Zhang J,Zhang Z,Elkahloun A,Cao D,Shen C,Wunderlich M,Wang Y,Neilly MB,Jin J,Wei M,Lu J,Valk PJM,Delwel R,Lowenberg B,Le Beau MM,Vardiman J,M

    更新日期：2012-02-21 00:00:00

  • Author Correction: Large intrinsic anomalous Hall effect in half-metallic ferromagnet Co3Sn2S2 with magnetic Weyl fermions.

    abstract：:The original version of this Article incorrectly omitted an affiliation of Hongming Weng: "Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, China"This has been corrected in both the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-06643-x

    authors： Wang Q,Xu Y,Lou R,Liu Z,Li M,Huang Y,Shen D,Weng H,Wang S,Lei H

    更新日期：2018-10-08 00:00:00

  • Mutants of Cre recombinase with improved accuracy.

    abstract：:Despite rapid advances in genome engineering technologies, inserting genes into precise locations in the human genome remains an outstanding problem. It has been suggested that site-specific recombinases can be adapted towards use as transgene delivery vectors. The specificity of recombinases can be altered either wit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3509

    authors： Eroshenko N,Church GM

    更新日期：2013-01-01 00:00:00

  • A neural circuit model of decision uncertainty and change-of-mind.

    abstract：:Decision-making is often accompanied by a degree of confidence on whether a choice is correct. Decision uncertainty, or lack in confidence, may lead to change-of-mind. Studies have identified the behavioural characteristics associated with decision confidence or change-of-mind, and their neural correlates. Although se...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10316-8

    authors： Atiya NAA,Rañó I,Prasad G,Wong-Lin K

    更新日期：2019-05-23 00:00:00

  • Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.

    abstract：:Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20059-6

    authors： Zhou Y,Yang D,Yang Q,Lv X,Huang W,Zhou Z,Wang Y,Zhang Z,Yuan T,Ding X,Tang L,Zhang J,Yin J,Huang Y,Yu W,Wang Y,Zhou C,Su Y,He A,Sun Y,Shen Z,Qian B,Meng W,Fei J,Yao Y,Pan X,Chen P,Hu H

    更新日期：2020-12-10 00:00:00