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Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.

Abstract：

:In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch--two central cell fate events--take place in the G1 phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G1/S transition, whose major regulatory feature is multisite phosphorylation of nuclear Whi5. Cln3-Cdk1, whose nuclear amount is proportional to cell size, and then Cln1,2-Cdk1, randomly phosphorylate both decoy and functional Whi5 sites. Full phosphorylation of functional sites releases Whi5 inhibitory activity, activating G1/S transcription. Simulation analysis shows that this mechanism ensures coherent release of Whi5 inhibitory action and accounts for many experimentally observed properties of mitotically growing or conjugating G1 cells. Cell cycle progression and transcriptional analyses of a Whi5 phosphomimetic mutant verify the model prediction that coherent transcription of the G1/S regulon and ensuing G1/S transition requires full phosphorylation of Whi5 functional sites.

journal_name

Nat Commun

journal_title

Nature communications

authors

Palumbo P,Vanoni M,Cusimano V,Busti S,Marano F,Manes C,Alberghina L

doi

10.1038/ncomms11372

subject

Has Abstract

pub_date

2016-04-20 00:00:00

pages

11372

issn

2041-1723

pii

ncomms11372

journal_volume

7

pub_type

杂志文章

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